痘毒未出之初，宜开和解之门，即出之后，当塞走泄之路。壮热腮红，便服干葛，
面青神慢，急进参苏，气粗热拥心须燥，便秘即当和解，喘呼腹胀，眼胞浮，肌燥急宜
疏散，及痘出之门即开，热蒸之势自解。未见点前，惟兹一法，既敷疮后，别有奇方，
稀疏而气血和平，须知安表和中之理，繁密而不胜重任，当识内外分消之妙，疮来赤色
见焦枯，则用清凉而解毒，红斑赤紫，芩连犀柏同施。身热燎人，干葛前胡并用。气粗
而腹胀膨膨，蝉蜕枳腹木通。血痹而腹疼阵阵，元胡楂芍木香。若遇色来红润，便宜彻
去连翘，如见二便清泄，总是生归俱兔，更加白术茯苓，自古名为平则至，如精神倦而
饮食少，进以人参，出不快而痘不呕。兼兮查子，初觉繁红稠密，紫草用之无疑，势
来毒甚色骄，阴绿进之何害？然三日以前只许遵斯而用，循是以往，不可以偶而施。假
如疮端放白，势在行浆，又当参看内外虚贼之异，酌以温平表补之宜，若神旺而气盛，
能食而便实者，痘虽繁密，只用中和表发，如防甘归桔芎楂 类，催脓而已。若精倦而
神衰，减食而痘陷，毒则繁多者，却用重剂补益，如参 桂桔芎归甘草为先，立此二
方，乃作酿脓之具，如脓胞未满，不可轻易其方。然痘变迁不一，随机又当妙用，至于
浆既饶足，毒已尽行拘化，则法当渐进清凉，如气血回元复伉，是又不可重崇表补，
参切勿多餐，胖甚恐难收拾，便实而能食，壮热而不退者，便宜疏利为先，升麻干
葛，四顺清凉。便溏而减食，壮热而不渴者，则以健脾为贵，木茯通归，防风赤芍，
如还内外症平，不必过冷服饵。待至结痂以后，再观余毒有无，当疏利便宜疏利，当调
补急宜调补，身热烦渴便赤者，大连翘饮。气粗壮热秘结者，四顺清凉，泄泻则宜黄理
中，疮痍则升麻干葛，如若别无余毒，则安养气血而已。
在痘毒尚未发出之前，应当采用和解的方法以开通邪气出路；一旦痘疹发出之后，则应当防止正气走泄。若出现高热、面颊发红，应服用干葛（葛根）；若面色青暗、精神萎靡，需急用参苏饮（人参、苏叶等组成的方剂）。若呼吸粗重、热邪壅盛于心胸且伴有烦躁，大便便秘时应当使用和解之法；若气喘呼噜、腹部胀满、眼睑浮肿、肌肤干燥紧绷，则急需疏散透发。等到痘疹发出的通道打开，蒸腾的热势自然就会解除。
在未见痘点之前，只适用这一种方法；既已敷布成疮后，另有奇妙的方剂。若痘疹稀疏而气血平和，必须懂得安和表里、调和中焦的道理；若痘疹繁密而身体不胜其任，应当认识内外分消毒邪的妙处。若痘疮颜色赤红并出现焦枯，则应用清凉药物以解毒；若见红斑赤紫，应将黄芩、黄连、犀角、侧柏叶同用。若身热炽烈如火燎人，将干葛与前胡并用。若呼吸粗重且腹部膨隆胀满，可用蝉蜕、枳壳、木通。若血行瘀滞导致腹痛阵阵，可用延胡索、山楂、白芍、木香。如果遇到痘色红润，便适宜去掉连翘；如果见到大小便清利通畅，总是生地黄与兔丝子（此处原文“俱兔”疑为“菟丝”或特定配伍，依语境归为补益类，暂译作相关药材）同用，再加白术、茯苓。自古以来这被称为“平则至”（指病情平稳时的治法）。
如果精神疲倦而饮食减少，进用人参；若痘出不快且不呕吐，兼加山楂子。初觉痘色繁红稠密，使用紫草无疑；若病势凶猛、毒气甚重、色泽骄亢，使用阴绿（此处可能指代某种清热解毒或特定草药，依原文直译）又有何害？然而三日以前只允许遵循这些方法用药，循此以往，不可以偶尔随意施用。
假如痘端变白，病势在于行浆（化脓阶段），又应当参考内虚外贼的不同情况，斟酌使用温平、解表、补益的适宜方法。如果精神旺盛、气力充足、能进食、大便坚实者，痘虽繁密，只用中和之剂以透发，如防风、甘草、当归、桔梗、川芎、山楂之类，仅用于催脓而已。如果精气疲倦、神气衰微、食欲减退、痘陷下、毒邪繁多者，却要用重剂补益，如人参、肉桂、桔梗、川芎、当归、甘草为先。设立这两个方子，是作为酿脓的工具。如果脓疱未满，不可轻易改变方剂。
然而痘疹变化不一，随机应变又当巧妙运用。至于浆液已经饶足，毒邪已经完全拘束化解，则治法应当逐渐进入清凉阶段。如果气血回复元气恢复强健，这时又不可过分推崇解表补益，人参切勿多服，胖盛恐怕难以收拾。若大便坚实、能进食、壮热而不退者，便适宜以疏利为先，用升麻、干葛，配合四顺清凉饮。若大便溏薄、食欲减退、壮热而不口渴者，则以健脾为贵，用木通、茯苓、通草、当归、防风、赤芍。如果内外症状平息，不必过冷服药。等到结痂以后，再观察是否有残余毒邪，若有余毒则应当疏利，若无余毒则应当调补。若身热烦渴、小便赤涩者，用大连翘饮。若气粗壮热、大便秘结者，用四顺清凉饮。若泄泻则宜用理中汤（原文“黄理中”推测为理中汤或含黄芩理中，依常规译为理中汤类），若疮痍未愈则用升麻、干葛。如果实在没有余毒，则只需安养气血而已。
Before the smallpox toxin has erupted, one should open the gate of harmonization (He Jie); after it has erupted, one must block the path of leakage and depletion. If there is high fever and red cheeks, Gan Ge (Puerariae Radix) should be taken; if the complexion is blueish and spirit is sluggish, Shen Su Yin (Ginseng and Perilla Decoction) should be urgently administered. If breathing is coarse, heat is congested in the heart causing irritability, and constipation occurs, harmonization methods should be used; if there is wheezing, abdominal distension, swollen eyelids, and dry/tight skin, dispersing and venting methods should be urgently applied. Once the pathway for the eruption of sores is opened, the steaming heat will naturally resolve.
Before spots appear, only this method applies; after sores have spread, there are other miraculous formulas. If the sores are sparse and Qi and Blood are peaceful, one must understand the principle of harmonizing the exterior and centering the middle. If the sores are dense and overwhelming, one must recognize the subtlety of resolving toxins from both interior and exterior. If the sores are red and appear scorched/dry, cooling herbs to clear heat and detoxify should be used; if red spots are crimson-purple, Huang Qin (Scutellariae Radix), Lian Lian (Coptidis Rhizoma), Xi Jiao (Rhinocerotis Cornu - note: modern substitutes usually used), and Bai Ye (Platycladi Cacumen) should be combined. If body heat is blazing like fire, Gan Ge (Puerariae Radix) and Qian Hu (Peucedani Radix) should be used together. If breathing is coarse and abdomen is distended, Chan Tui (Cicadae Periostracum), Zhi Ke (Aurantii Fructus), and Mu Tong (Akebiae Caulis) should be used. If blood stasis causes paroxysmal abdominal pain, Yuan Hu (Corydalis Rhizoma), Zha Shi (Crataegi Fructus), Shao Yao (Paeoniae Radix Alba), and Mu Xiang (Aucklandiae Radix) should be used. If the color is ruddy and moist, Lian Qiao (Forsythiae Fructum) should be removed; if urination and defecation are clear and smooth, Sheng Di Huang (Rehmanniae Radix) and Tu Si Zi (Cuscutae Semen) [Note: 'Ju Tu' interpreted contextually] along with Bai Zhu (Atractylodis Macrocephalae Rhizoma) and Fu Ling (Poria) should be added. This has been called "Ping Ze Zhi" since ancient times.
If spirit is fatigued and intake is low, Ren Shen (Ginseng Radix et Rhizoma) should be advanced; if eruption is slow but without vomiting, Shan Zha (Crataegi Fructus) should be added. If initially the redness is dense and thick, Zi Cao (Arnebiae Radix seu Lithospermi Radix) should be used without doubt; if the momentum is severe, toxins are heavy, and the color is arrogant/bright, using Yin Lv [Note: specific herb reference] what harm is there? However, before the third day, only these methods are permitted; following this path, one cannot apply them casually.
Suppose the sore tips turn white, indicating the stage of pus formation; one must then examine the differences between internal deficiency and external pathogens, and decide on appropriate warming, level-balancing, exterior-releasing, and tonifying methods. If spirit is vigorous, Qi is abundant, food intake is normal, and stools are solid, even if sores are dense, only a neutral formula to release the exterior should be used, such as Fang Feng (Saposhnikoviae Radix), Gan Cao (Glycyrrhizae Radix et Rhizoma), Dang Gui (Angelicae Sinensis Radix), Jie Geng (Platycodonis Radix), Xiong Qiong (Ligustici Chuanxiong Rhizoma), and Zha Shi (Crataegi Fructus), merely to promote pus formation. If essence is exhausted, spirit is weak, appetite is reduced, sores are depressed, and toxins are numerous, heavy tonifying agents should be used, such as Ren Shen (Ginseng Radix et Rhizoma), Gui Zhi (Cinnamomi Ramulus), Jie Geng (Platycodonis Radix), Xiong Qiong (Ligustici Chuanxiong Rhizoma), Dang Gui (Angelicae Sinensis Radix), and Gan Cao (Glycyrrhizae Radix et Rhizoma) as priority. These two formulas are established as tools for nourishing pus. If pustules are not yet full, do not change the formula lightly.
However, smallpox changes vary; one must use wisdom according to circumstances. When the pus is abundant and toxins are fully resolved/constrained, the method should gradually shift to cooling. If Qi and Blood return to their original strength, one must not excessively advocate exterior-releasing and tonifying; Ren Shen (Ginseng Radix et Rhizoma) should not be taken in large amounts, as excessive fullness may be difficult to manage. If stools are solid, food intake is good, and high fever persists, purgative and draining methods should be prioritized, using Sheng Ma (Cimicifugae Rhizoma), Gan Ge (Puerariae Radix), and Si Shun Qing Liang Yin (Four-Smooth Cooling Decoction). If stools are loose, appetite is reduced, and high fever exists without thirst, strengthening the Spleen is paramount, using Mu Tong (Akebiae Caulis), Fu Ling (Poria), Tong Cao (Tetrapanacis Medulla), Dang Gui (Angelicae Sinensis Radix), Fang Feng (Saposhnikoviae Radix), and Chi Shao (Paeoniae Radix Rubra). If internal and external symptoms are balanced, cold medicines need not be overused. After scabbing forms, observe whether residual toxins remain; if so, drain and purge; if not, tonify and regulate. If there is fever, irritability, thirst, and dark urine, Da Lian Qiao Yin (Large Forsythia Decoction) is used. If Qi is coarse, heat is strong, and constipation exists, Si Shun Qing Liang Yin (Four-Smooth Cooling Decoction) is used. If diarrhea occurs, Li Zhong Tang (Regulate the Middle Decoction) is suitable. If sores persist, Sheng Ma (Cimicifugae Rhizoma) and Gan Ge (Puerariae Radix) are used. If truly no residual toxins exist, simply nourish and rest Qi and Blood.