治热结在内, 心下急呕不止, 郁郁微烦, 柴胡证仍
在者, 与大柴胡汤下之.
柴胡半斤 黄芩三两 半夏半升 芍药三两 枳实四枚 大黄二两
生姜五两 大枣 ( 擘 ) 十二升, 右八味, 以水一斗二升, 煮取六升
,去滓再煎, 温服一升, 日三服.
【注】柴胡证在, 又复有里, 故立少阳两解法也. 以小柴胡汤加枳实
,芍药者, 仍解其外以和其内也. 去参, 草者, 以里不虚. 稍加大黄
,以泻结热. 倍生姜者, 因呕不止也. 斯方也, 柴胡得生姜之倍, 解
半表之功捷, 枳, 芍得大黄之少, 攻半里之效徐, 虽云下之, 亦下中
之和剂也.
伤寒六, 七日, 发热微恶寒, 肢节烦疼微呕, 心
下支结, 此太阳少阳并病也, 柴胡桂枝汤主之.
柴胡四两 桂枝一两半 人参一两半 甘草一两 半夏 ( 洗 ) 二合
半 黄芩一两半 芍药一两半 大枣 ( 擘 ) 六枚 生姜 ( 切 ) 一
两半, , 右九味, 以水七升, 煮取三升, 去滓, 分温服.
【集注】柯琴曰: 仲景书中最重柴, 桂二方, 以桂枝解太阳肌表, 又
可以调诸经之肌表; 小柴胡解少阳半表, 亦可以和三阳之半表. 故于
六经病外, 独有桂枝证, 柴胡证之称, 见二方之任重不拘于经也. 如
阳浮阴弱条, 是仲景自为桂枝证之注释; 血弱气虚条, 是仲景自为柴
胡证之注释. 桂枝有坏病, 柴胡亦有坏病, 桂枝有疑似证. 柴胡亦有
疑似证. 病如桂枝证而实非, 若脚挛急与胸中痞硬者是已. 病如柴胡
证而实非, 本渴而饮水呕食谷呕, 与但欲呕胸中痛微溏者是已. 此条
为伤寒六七日, 正寒热当退之时, 反见发热恶寒诸表证, 更见心下支
结诸里证, 表里不解, 法当表里双解之. 然恶寒微, 发热亦微, 可知
肢节烦疼, 则一身骨节不疼; 可知微呕, 心下亦微结, 故谓之支结.
表证虽不去而已轻, 里证虽已见而未甚. 故取桂枝之半, 以散太阳未
尽之邪; 取柴胡之半, 以解少阳微结之证. 口不渴, 身有微热者, 法
当去人参; 以六, 七日来, 邪虽未解, 而正已虚, 故仍用之. 外证虽
在,而病机已见于里, 故方以柴胡冠桂枝之上, 为双解两阳之轻剂也
.
治疗热邪结聚于体内,胃脘部拘急不适、呕吐不止,心中郁郁不舒且轻微烦躁,同时柴胡证候仍然存在的患者,给予大柴胡汤进行攻下治疗。
大柴胡汤方:柴胡半斤,黄芩三两,半夏半升,芍药三两,枳实四枚,大黄二两,生姜五两,大枣(掰开)十二枚。以上八味药,用水一斗二升,煎煮至六升,滤去药渣后再次煎煮,每次温服一升,每日服用三次。
【注释】柴胡证候仍在,同时又伴有里实证,因此确立少阳病表里双解的治法。使用小柴胡汤加入枳实、芍药,是为了继续解除在表之邪并调和内部气机。去掉人参、甘草,是因为里证并非虚证。稍微加大黄用量,是为了泻除结聚的热邪。加倍使用生姜,是因为呕吐不止。此方中,柴胡配合加倍的生姜,解除半表之邪的功效迅速;枳实、芍药配合少量大黄,攻逐半里之邪的效果较为缓和。虽然称为“下法”,但也属于下法中的和剂。
伤寒病程经过六七天,出现发热、轻微恶寒,肢体关节烦扰疼痛,轻微呕吐,胃脘部有支撑感且结滞不通,这是太阳病与少阳病并见的病症,应当用柴胡桂枝汤主治。
柴胡桂枝汤方:柴胡四两,桂枝一两半,人参一两半,甘草一两,半夏(洗净)二合半,黄芩一两半,芍药一两半,大枣(掰开)六枚,生姜(切)一两半。以上九味药,用水七升,煎煮至三升,滤去药渣,分次温服。
【集注】柯琴说:张仲景的书中,最重视柴胡汤和桂枝汤这两首方剂。桂枝汤能解除太阳经肌表的邪气,也可以调节其他各经肌表的邪气;小柴胡汤能解除少阳经半表半里的邪气,也能调和三阳经半表半里的邪气。因此在六经病的分类之外,唯独有“桂枝证”和“柴胡证”的说法,可见这两首方剂的作用重大,并不局限于某一经的病证。例如,“阳浮阴弱”这一条文,是张仲景亲自为桂枝证所作的注释;“血弱气尽”这一条文,是张仲景亲自为柴胡证所作的注释。桂枝汤证会有误治后的坏病,柴胡汤证也有坏病;桂枝汤证有疑似证,柴胡汤证也有疑似证。病情看似桂枝证但实际上不是的,比如脚部挛急和胸中痞塞坚硬就是这类情况。病情看似柴胡证但实际上不是的,比如本来口渴却因饮水而呕吐、进食而呕吐,以及只想呕吐、胸痛伴轻微腹泻就是这类情况。本条所述为伤寒六七天,正是寒热应当消退的时候,反而出现发热恶寒等表证,更出现胃脘部支撑结滞等里证,表里之邪均未解除,依法应当采用表里双解的方法。然而恶寒轻微,发热也轻微,由此可知肢体关节烦疼,说明全身骨节并未剧烈疼痛;由此可知轻微呕吐,说明胃脘部也只是轻微结滞,所以称之为“支结”。表证虽然未去但已经减轻,里证虽然出现但并不严重。因此取桂枝汤的一半剂量,以发散太阳经未尽的邪气;取小柴胡汤的一半剂量,以解除少阳经轻微结滞的证候。口不渴、身体有微热的,依法应当去掉人参;但因为病程已过六七天,邪气虽然未解,正气已经虚弱,所以仍然保留人参。外在证候虽然存在,但病机已经表现在里,所以方剂名称将柴胡置于桂枝之上,作为双解太阳、少阳两经的轻剂。
Treat patients with heat accumulation internally, urgency and intractable vomiting in the epigastrium (heart below), mild depression and irritability, while the Shaoyang syndrome (Shaoyang disease pattern) still persists, by administering Dahuang Huangqi Tang (Major Rhubarb and Bupleurum Decoction) to purge.
Dahuang Huangqi Tang Formula: Chaihu (Bupleuri Radix) half jin, Huangqin (Scutellariae Radix) three liang, Banxia (Pinelliae Rhizoma Preparatum) half sheng, Shaoyao (Paeoniae Radix Alba) three liang, Zhishi (Aurantii Fructus Immaturus) four pieces, Dahuang (Rhei Radix et Rhizoma) two liang, Shengjiang (Zingiberis Rhizoma Recens) five liang, Dazao (Jujubae Fructus) twelve pieces (torn open). The above eight herbs, with water one dou and two sheng, decoct to obtain six sheng, remove the dregs and decoct again, take one sheng warm each time, three times a day.
[Note] Since the Shaoyang syndrome persists and there is additionally an interior excess condition, the method of resolving both exterior and interior for Shaoyang disease is established. Using Xiaochaihu Tang (Minor Bupleurum Decoction) plus Zhishi and Shaoyao continues to resolve the exterior pathogen and harmonize the interior. Removing Renshen (Ginseng Radix et Rhizoma) and Gancao (Glycyrrhizae Radix et Rhizoma) is because the interior is not deficient. Slightly increasing the dose of Dahuang is to purge the accumulated heat. Doubling the amount of Shengjiang is due to intractable vomiting. In this formula, Chaihu combined with doubled Shengjiang rapidly resolves the half-exterior pathogen; Zhishi and Shaoyao combined with a small amount of Dahuang slowly attack the half-interior pathogen. Although termed a "purging method," it is also a harmonizing agent within purging methods.
After six or seven days of Shanghan (Cold Damage), presenting with fever, slight aversion to cold, vexing pain in the limbs and joints, slight vomiting, and a sensation of support and stagnation in the epigastrium, this is a concurrent disease of Taiyang (Greater Yang) and Shaoyang, which should be treated with Chaihu Guizhi Tang (Bupleurum and Cinnamon Twig Decoction).
Chaihu Guizhi Tang Formula: Chaihu (Bupleuri Radix) four liang, Guizhi (Cinnamomi Ramulus) one liang and half, Renshen (Ginseng Radix et Rhizoma) one liang and half, Gancao (Glycyrrhizae Radix et Rhizoma) one liang, Banxia (Pinelliae Rhizoma Preparatum, washed) two he and half, Huangqin (Scutellariae Radix) one liang and half, Shaoyao (Paeoniae Radix Alba) one liang and half, Dazao (Jujubae Fructus, torn open) six pieces, Shengjiang (Zingiberis Rhizoma Recens, sliced) one liang and half. The above nine herbs, with water seven sheng, decoct to obtain three sheng, remove the dregs, and divide into warm doses.
[Collected Notes] Ke Qin stated: Among Zhang Zhongjing's writings, the two most important formulas are Chaihu Tang and Guizhi Tang. Guizhi Tang resolves the muscle-surface pathogen of Taiyang and can also regulate the muscle-surface of various meridians; Xiaochaihu Tang resolves the half-exterior/half-interior pathogen of Shaoyang and can also harmonize the half-exterior/half-interior of the Three Yang meridians. Therefore, outside the classification of the Six Meridians diseases, there are exclusively terms like "Guizhi Syndrome" and "Chaihu Syndrome," indicating that these two formulas have significant roles and are not confined to specific meridians. For instance, the clause "Yang floating and Yin weak" is Zhang Zhongjing's own annotation for Guizhi Syndrome; the clause "Blood deficiency and Qi exhaustion" is his own annotation for Chaihu Syndrome. Guizhi Syndrome cases can deteriorate into Huabing (mismanaged diseases), and Chaihu Syndrome cases can also become Huabing; Guizhi Syndrome has suspected/ambiguous patterns, and Chaihu Syndrome also has ambiguous patterns. Conditions resembling Guizhi Syndrome but actually being different include leg cramping and chest fullness with hardness. Conditions resembling Chaihu Syndrome but actually being different include thirst with vomiting after drinking or eating, and only wanting to vomit with chest pain and slight diarrhea. This clause describes the period of six or seven days in Shanghan, when chills and fever should normally recede, yet exterior symptoms like fever and aversion to cold appear, along with interior symptoms like epigastric support and stagnation. Since neither exterior nor interior pathogens are resolved, the legal treatment requires simultaneous resolution of both. However, since aversion to cold is slight and fever is also slight, it can be inferred that limb joint pain indicates no severe bone and joint pain throughout the body; slight vomiting implies only slight epigastric stagnation, hence termed "supportive stagnation." Although the exterior syndrome remains, it has lightened; although the interior syndrome appears, it is not severe. Therefore, half the dose of Guizhi Tang is used to disperse the remaining Taiyang pathogen; half the dose of Xiaochaihu Tang is used to resolve the slight Shaoyang stagnation. When there is no thirst and slight body heat, Renshen should legally be removed; however, after six or seven days, although the pathogen is unresolved, the healthy Qi is already deficient, so Renshen is retained. Although external symptoms persist, the disease mechanism manifests in the interior; thus, the formula name places Chaihu before Guizhi, serving as a light agent to simultaneously resolve the Two Yangs (Taiyang and Shaoyang).