羌活 防风 苍术 细辛 川芎 白芷 黄芩 甘草 生地黄
触冒四时不正之气，而成时气病，憎寒壮热，头疼身痛，口渴。人人相似者，此方主之
。
谓春时应暖而反大寒，夏时应热而反大凉，秋时应凉而反大热，冬时应寒而反大温，此
非其时而有其气。是以一岁之中，长幼之病多相似也。药之为性，辛者得天地之金气，于人
则为义，故能匡正而黜邪。羌、防、苍、细、芎、芷，皆辛物也，分经而主治∶邪在太阳者，
治以羌活；邪在阳明者，治以白芷；邪在少阳者，治以黄芩；邪在太阴者，治以苍术；邪在
少阴者，治以细辛；邪在厥阴者，治以川芎；而防风者，又诸药之卒徒也。用生地，所以去
血中之热；而甘草者，又所以和诸药而除气中之热也；易老自序云∶此方冬可以治寒，夏可
以治热，春可以治温，秋可以治湿，是诸路之应兵也。用之以治四时瘟疠，诚为稳当，但于
阴虚、气弱之人，在所禁尔！
石膏（一两五钱，生用） 黄芩（炒） 黄连（炒） 黄柏（各五钱） 山栀（三十枚，
炒黑）
麻黄（去节） 淡豉（各二两）
瘟毒表里俱盛，五心烦热，两目如火，鼻干面赤，大渴舌燥者，此方主之。
寒毒藏于肌肤，至夏变为热病；热病未除，更遇温热，名曰瘟毒。热病之最重者，寒能
制热，故用石膏；苦能下热，故用芩、连、栀、柏；佐以麻黄、淡豉之发散者，以温热至深，
表里俱实，降之则郁，扬之则越，郁则温热犹存，兼之以发扬，则炎炎之势皆烬矣。此内外
分消其势，兵之分击者也。
感受四时不正之气，从而形成时气病（季节性流行病），出现憎恶寒冷且高热、头痛身体疼痛、口渴等症状。如果患者症状人人相似，此方主治。
所谓春时应温暖却反而大寒，夏时应炎热却反而大凉，秋时应凉爽却反而大热，冬时应寒冷却反而大温，这是非其时令而有其气候。因此一年之中，无论老少患病多相似。药物的性质，辛味的药得天地之金气，在人体则对应“义”的德行，所以能匡扶正气而驱除邪气。羌活、防风、苍术、细辛、川芎、白芷，都是辛味药物，分别归经主治：邪气在太阳经（足太阳膀胱经）者，用羌活治疗；邪气在阳明经（足阳明胃经）者，用白芷治疗；邪气在少阳经（足少阳胆经）者，用黄芩治疗；邪气在太阴经（足太阴脾经）者，用苍术治疗；邪气在少阴经（足少阴肾经）者，用细辛治疗；邪气在厥阴经（足厥阴肝经）者，用川芎治疗；而防风，又是这些药物的先锋士卒。使用生地黄，是为了清除血中的热邪；而甘草，则是为了调和诸药并清除气中的热邪。易老（张元素）自序说：此方冬天可以治寒，夏天可以治热，春天可以治温，秋天可以治湿，是各路应对之兵。用它来治疗四时瘟疫疠气，确实稳妥得当，但对于阴虚、气弱的人，则在禁忌之列！
石膏（一两五钱，生用）、黄芩（炒制）、黄连（炒制）、黄柏（各五钱）、山栀（三十枚，炒黑）。
麻黄（去节）、淡豉（各二两）。
瘟毒邪气表里俱盛，出现五心烦热（两手心、两足心及心胸烦热）、双眼如火烧、鼻干面赤、极度口渴舌燥者，此方主治。
寒毒潜伏于肌肤，到了夏天变为热病；热病未除，又遇到温热之气，名叫瘟毒。这是热病中最严重的类型。寒能制约热，所以用石膏；苦味能降泄热邪，所以用黄芩、黄连、山栀、黄柏；佐以麻黄、淡豆豉的发散作用，是因为温热邪气深入，表里俱实，单纯降泄会导致郁结，单纯升发则会助长火势，郁结则温热邪气仍存，配合发扬发散，则炎炎之势皆被扑灭。这是内外分消邪势，如同军队分头攻击的策略。
Qianghuo (Notopterygii Rhizoma et Radix), Fangfeng (Saposhnikoviae Radix), Cangzhu (Atractylodis Rhizoma), Xixin (Asari Radix et Rhizoma), Chuanxiong (Ligustici Chuanxiong Rhizoma), Baizhi (Angelicae Dahuricae Radix), Huangqin (Scutellariae Radix), Gancao (Glycyrrhizae Radix et Rhizoma), Shengdihuang (Rehmanniae Radix).
Contracting the abnormal Qi of the four seasons leads to Shiqi Bing (Seasonal Epidemic Disease), characterized by aversion to cold with high fever, headache and body ache, and thirst. When symptoms are similar among many people, this formula is indicated.
It refers to situations where spring should be warm but is excessively cold, summer should be hot but is excessively cool, autumn should be cool but is excessively hot, and winter should be cold but is excessively warm; this is having the climate of one season in another. Therefore, throughout the year, illnesses among people of all ages tend to be similar. The nature of herbs: those with a pungent flavor receive the Metal Qi of Heaven and Earth, which corresponds to "Righteousness" in humans, thus enabling them to support upright Qi and expel pathogenic factors. Qianghuo, Fangfeng, Cangzhu, Xixin, Chuanxiong, and Baizhi are all pungent substances, each governing specific meridians: for pathogens in Taiyang Jing (Taiyang Meridian), treat with Qianghuo; for pathogens in Yangming Jing (Yangming Meridian), treat with Baizhi; for pathogens in Shaoyang Jing (Shaoyang Meridian), treat with Huangqin; for pathogens in Taiyin Jing (Taiyin Meridian), treat with Cangzhu; for pathogens in Shaoyin Jing (Shaoyin Meridian), treat with Xixin; for pathogens in Jueyin Jing (Jueyin Meridian), treat with Chuanxiong; while Fangfeng serves as the vanguard for these herbs. Shengdihuang is used to clear heat from the blood; Gancao harmonizes the various herbs and clears heat from the Qi. Ziyi Lao (Zhang Yuansu) stated in his preface: This formula can treat cold in winter, heat in summer, warmth in spring, and dampness in autumn; it is an army ready to respond on all fronts. Using it to treat epidemics of the four seasons is indeed prudent, but it is contraindicated for individuals with Yin deficiency or weak Qi!
Shigao (Gypsum Fibrosum, 1 liang 5 qian, raw), Huangqin (Scutellariae Radix, stir-fried), Huanglian (Coptidis Rhizoma, stir-fried), Huangbai (Phellodendri Cortex, 5 qian each), Shanzhi (Gardeniae Fructus, 30 pieces, stir-fried until black).
Mahuang (Ephedrae Herba, nodes removed), Danshi (Sojae Semen Praeparatum, 2 liang each).
For Wendu (Plague Toxin) where both exterior and interior are full of excess, presenting with five-palm heat (heat sensation in palms, soles, and chest), eyes burning like fire, dry nose and red face, extreme thirst and dry tongue, this formula is indicated.
Cold toxin hides in the skin and muscles, transforming into Heat Disease in summer; if Heat Disease is not resolved and is further exposed to warm-heat, it is named Wendu. This is the most severe type of heat disease. Cold can control heat, hence Shigao is used; Bitter flavor can drain heat, hence Huangqin, Huanglian, Shanzhi, and Huangbai are used; assisted by the dispersing action of Mahuang and Danshi, because warm-heat pathogens have penetrated deeply, making both exterior and interior solid. Pure draining causes stagnation, pure raising exacerbates the fire. Stagnation leaves heat intact; combining raising and dispersing extinguishes the blazing momentum. This strategy dissipates the pathogenic potential internally and externally, akin to troops attacking from different directions.