The classics state that the richness or scarcity of local products varies among people in the five directions: East, West, South, North, and Center. The elevation or depression of dwellings, as well as the wind, cold, summer heat, and dampness, differ from place to place. The daily consumption of grains also varies considerably. Therefore, Huangdi raised questions regarding the five directions, and Qibo presented the merits of treatments tailored to the five regions. Methods such as acupuncture (Zhenjiu), Bian stone therapy, washing, and moxibustion are applications suited to the conditions of the five directions. Nowadays, individuals vary in physical strength, being either weak or robust; given the differences in the five soils, students of medicine should examine these factors in detail and must not neglect them.

Prostitutes belong to the trade of flowers and willows, accessible to all. They engage in sexual intercourse daily with little interval. Pimps age easily because their essence is depleted in their early years. Although they receive nourishment from men's yang essence, do they not leak their own? Thus it is said: "Things that taste good, if eaten too much, eventually cause disease; matters that bring pleasure, if indulged excessively, easily lead to disaster." Clients are the same. Why do sores in such people often fail to heal? It is likely due to insufficiency of essence and blood, making it difficult for sores to suppurate and difficult for wounds to close. Large doses of supporting methods (Tuo Fa) and tonifying methods must be used, and sexual activity must be prohibited first; recovery takes at least a hundred days. This taboo applies not only to various sores but is also the source of health preservation.

Obese people tend to have excessive dampness and phlegm, and Qi deficiency. Those who appear solid externally have excess flesh, while those who are deficient internally suffer from Qi deficiency. Therefore, when people with Qi deficiency develop sores, they often suffer from carbuncles (Yong). A carbuncle implies obstruction. It belongs to Yang and is located on the exterior. Qi deficiency equates to exterior deficiency, leading to external edema. The skin is thin and red. Internal support (Nei Tuo) is appropriate to prevent the pathogenic factor from sinking inward, facilitating both suppuration and healing. Zhu Danxi stated that obese people should be treated with Erchen Tang (Two-Cured Decoction) added with Ren Shen (Ginseng Radix), Dang Gui (Angelicae Sinensis Radix), Bai Zhu (Atractylodis Macrocephalae Rhizoma), Jin Yin Hua (Lonicerae Japonicae Flos), Lian Qiao (Forsythiae Fructus), etc. There is no deviation from this principle. Students should observe this carefully.

Emaciated people tend to have excessive fire and blood deficiency. Blood deficiency constitutes Yin deficiency; Yin deficiency leads to hyperactive fire; hyperactive fire causes fever. Their sinews and bones are thin and cannot withstand cold. Generally, their skin is loose and muscles flaccid. If they develop sores, they often suffer from deep abscesses (Ju). A deep abscess implies blockage. It belongs to Yin. Because Ying (Nutritive) blood becomes stagnant and does not flow smoothly, there is Yin stagnation obstructing Yang, and blood stagnation obstructing Qi, resulting in a Ju. It is further said that Ju represents toxicity of the Five Zang organs, while Yong represents toxicity of the Six Fu organs. Therefore, Ju often attaches to the bone, with unchanged muscle color, making it difficult to suppurate. Even after suppuration, it is difficult to heal. Treatment should involve Bajzhen Tang (Eight-Treasure Decoction) modified with Jin Yin Hua, Lian Qiao, Fu Zi (Aconiti Lateralis Radix Praeparata), etc. The subtlety lies in not adhering rigidly to a fixed formula; this characterizes a skilled physician. Students should ponder this.