〔薛〕经曰∶心藏神，有余则笑不休。又曰∶在脏为心，在声为笑，在志为喜。
又，火太过，曰赫曦，赫曦之纪，其病笑谑狂妄。又云∶少阴所至，为喜笑。又云∶
精气并于心则喜。此数者，皆言属心火也，若笑不休，呻而为腹痛，此水乘于火，
阴击于阳，阳伏热生，狂妄谵语不可闻，心之损矣。扁鹊云∶其人唇口赤色者可治，
青黑者死。若肾水亏涸，不胜心火，而喜笑不休者，用六味地黄丸。肝火炽盛，能
生心火，而喜笑不休者，用柴胡清肝散。余兼别证，各从其证而参治之。一小儿喜
笑常作，不安，面赤饮冷，手足并热。先用黄连泻心汤末，二服稍定，又用六味地
黄丸料煎服顿愈，常服此丸则安，月许不服，仍复作，又服，愈矣。一小儿患前
证，面青赤。此肝心二经风热所致也。用柴胡栀子散、六味地黄丸渐愈。又因乳
母大怒发热。先用加味柴胡汤，又用加味逍遥散，母子服之并愈。一小儿年十四
岁，用心过度，饮食失节，患喜笑不休，脉洪大而虚，面色赤而或白。余用补中益
气汤而愈。次秋科举，饮食劳倦，前证复作，或兼谵语，脉洪大，按之微细如
无。用人参一两，姜枣煎服，稍定，又三剂而愈。又因劳役用心，自汗作渴，烦躁
似痫证。先用当归补血汤，二剂顿安，又十全大补汤而寻愈。
薛己说：《内经》记载：“心藏神，有余则笑不休。”又说：“在脏为心，在声为笑，在志为喜。”
另外，火气太过，称为“赫曦”（盛大炽热），赫曦之年，其病症表现为笑谑狂妄。又说：“少阴经气至时，表现为喜笑。”又说：“精气并聚于心则喜。”这些说法，都是指属于心火的问题。如果笑不止，呻吟且伴有腹痛，这是水邪乘袭火位，阴气击伤阳气，阳气被伏郁而化热生火，出现狂妄、胡言乱语不可听闻的症状，这是心的损伤所致。扁鹊说：患者嘴唇口角呈赤色的可以治愈，呈青黑色的预后不良死亡。如果是肾水亏虚枯竭，不能制约心火，而导致喜笑不止的，使用六味地黄丸。肝火炽盛，能够滋生心火，而导致喜笑不止的，使用柴胡清肝散。其余兼有其他证候的，分别根据各自证候参合治疗。
有一个小儿经常喜笑，心神不安，面色红赤，想喝冷水，手足发热。先用黄连泻心汤研末服用，服两剂后稍见安定，又用六味地黄丸药料煎服，顿时痊愈。常服此丸则平安，一个月不服，病仍复发，再服药，就好了。
另一个小儿患前述证候，面色青赤。这是肝、心二经受风热侵袭所致。使用柴胡栀子散、六味地黄丸逐渐痊愈。又因乳母大怒发热。先用加味柴胡汤，又用加味逍遥散，母子同服都痊愈了。
还有一个十四岁的小儿，用心过度，饮食不节制，患喜笑不止，脉象洪大但按之空虚，面色红赤或苍白。我用补中益气汤治愈。次年秋天参加科举考试，因饮食和劳倦，前证复发，有时兼有胡言乱语，脉象洪大，重按微细若无。用人参一两，加生姜、大枣煎服，稍见安定，又服三剂而痊愈。后来又因劳累过度、思虑过多，自汗出、口渴、烦躁似癫痫发作。先用当归补血汤，服两剂顿时安宁，又用十全大补汤不久即愈。
Xue Ji stated: The *Neijing* records, "The Heart stores the Shen (Spirit); when in excess, there is incessant laughter." It also states, "In the Zang organs it corresponds to the Heart; in vocalization it corresponds to laughter; in emotions it corresponds to joy."
Furthermore, excessive Fire is called "He Xi" (abundant and blazing heat). In years of He Xi, the diseases manifest as laughing, jesting, madness, and delirium. It is also said, "When the Shaoyin [Kidney/Heart] qi arrives, it manifests as joy and laughter." It is further stated, "When Jing Qi (Essence Qi) converges in the Heart, there is joy." These statements all indicate conditions belonging to Heart Fire. If laughter is incessant accompanied by groaning and abdominal pain, this is Water encroaching upon Fire, with Yin striking Yang. Yang becomes trapped and generates heat, leading to madness, delirious speech that is incomprehensible, which indicates damage to the Heart. Bian Que said: If the patient's lips and mouth are red, the condition is treatable; if they are blue-black, it is fatal. If Kidney Water is deficient and dry, failing to control Heart Fire, resulting in incessant joy and laughter, use Liuwei Dihuang Wan (Six-Ingredient Rehmannia Pill). If Liver Fire is blazing, generating Heart Fire, resulting in incessant joy and laughter, use Chaihu Qinggan San (Bupleurum Liver-Clearing Powder). For other accompanying syndromes, treatment should be adapted according to each specific syndrome.
A child frequently laughed and was restless, with a red face, desire for cold drinks, and hot hands and feet. Initially, Huanglian Xie Xin Tang (Coptis Decoction to Drain the Heart) powder was administered; after two doses, the condition slightly stabilized. Subsequently, Liuwei Dihuang Wan (Six-Ingredient Rehmannia Pill) ingredients were decocted and taken, resulting in immediate recovery. Regular consumption of this pill ensured stability; if not taken for a month, the symptoms recurred, but resuming medication cured it again.
Another child presented with the aforementioned symptoms, showing a bluish-red complexion. This was caused by Wind-Heat affecting the Liver and Heart meridians. Chaihu Zhizi San (Bupleurum and Gardenia Powder) and Liuwei Dihuang Wan (Six-Ingredient Rehmannia Pill) were used, leading to gradual recovery. Additionally, the wet nurse suffered from anger-induced fever. Jiawei Chaihu Tang (Modified Bupleurum Decoction) was initially used, followed by Jiawei Xiaoyao San (Modified Free Wanderer Powder), both mother and child recovering after taking them.
A fourteen-year-old child, having overused mental effort and irregular diet, suffered from incessant laughter. The pulse was large and surging yet empty upon pressure; the complexion was red or pale. Bu Zhong Yi Qi Tang (Tonify the Middle and Augment the Qi Decoction) was used to effect a cure. In the following autumn, during the imperial examinations, due to dietary indiscretion and fatigue, the previous condition recurred, sometimes accompanied by delirious speech. The pulse was large and surging, but fine and nearly imperceptible upon deep pressure. Ren Shen (Ginseng Root) 1 liang, decocted with Sheng Jiang (Fresh Ginger Rhizome) and Da Zao (Jujube Fruit), was administered; the condition slightly stabilized, and three additional doses led to full recovery. Later, due to physical labor and mental strain, spontaneous sweating, thirst, and irritability resembling epilepsy occurred. Dang Gui Bu Xue Tang (Angelica Tonifying Blood Decoction) was initially used; after two doses, calmness was restored. Finally, Shiquan Dabu Tang (Ten Substance Great Tonic Decoction) was administered, leading to swift recovery.