时疫为湿热，小便多者甚少。传里之后，或有小便多者，乃胃土变为燥热也，急下之。屡经下后，小便多者，
气虚也，益气升阳为主。亦有肾虚而小便多者，六味地黄汤加五味子。大抵未下之先，小便多者属燥热，小便必微
黄，必烦热，渴而喜饮。既下之后，小便多者属虚。气虚则不喜饮，而寸脉不及尺，浮不及沉；阴虚则喜饮，而尺
脉不及寸，沉不及浮，失治日久，则变消渴。时疫小便多者如此，若夫风寒小便多，则属阳虚，不在此例。
时疫初起遗尿者，多属三阳合病。盖邪入于阳则阳实而阴虚，热盛于表，里为之不守，又神昏于上，不自知其
下部之出入，故遗尿也。合之腹满身重，口不仁而面垢，谵语，仲景独主白虎汤。此证不可下，以邪全盛在表、在
经，下之则表邪内陷，故额上少汗，手足逆冷。尤不可汗，以邪本属热，汗之则愈增其热，故心愦愦，反作谵语。
惟以白虎汤清其浮越之热，若别兼燥结、 痛者，可于本汤内加大黄下之。
时疫囊缩，乃热入于厥阴也。有结有热则下，有热无结则清，热退而囊自纵矣。阴证囊缩与时疫颇相类，以阴
证囊缩必身冷、厥逆、脉沉，时疫囊缩亦身冷、厥逆、脉沉也。然一寒、一热，自有不同。阴证囊缩阴茎萎缩，或
全缩入腹有如妇人；时疫热厥囊缩，阴茎如常。再以兼证辨之，阴证囊缩小便清，少腹牵引作痛而不满，喜温按，
多自利，神清不烦；时疫囊缩小便赤，少腹满而硬痛拒按，大便秘，烦而神昏。
时疫（流行性疫病）由湿热邪气引起，出现小便频多症状的情况很少见。病邪传入体内之后，偶尔会出现小便频多的情况，这是胃土转化为燥热所致，应当紧急使用攻下法治疗。经过多次攻下治疗后，如果仍然小便频多，属于气虚，治疗应以益气升阳为主。也有因肾虚导致小便频多的，可用六味地黄汤加入五味子。大抵在未经过攻下治疗之前，小便频多属于燥热证，小便颜色必定微黄，必定伴有烦热、口渴且喜欢饮水的症状。经过攻下治疗后，小便频多属于虚证。如果是气虚，则不喜欢饮水，且寸口脉弱于尺部脉，浮取脉象弱于沉取脉象；如果是阴虚，则喜欢饮水，且尺部脉弱于寸口脉，沉取脉象弱于浮取脉象。若失治日久，则会转变为消渴病。时疫中出现的小便频多大致如此。至于风寒引起的小便频多，则属于阳虚，不在此例讨论范围内。
时疫初起阶段出现遗尿的，大多属于三阳合病。因为邪气侵入阳经，导致阳气实而阴气虚，体表热势炽盛，里气不能固守，加上神志昏蒙于上焦，患者不自知下部排泄物的排出，所以发生遗尿。此证若兼见腹部胀满、身体沉重、口舌不知滋味且面色污垢、胡言乱语等症状，张仲景主张单独使用白虎汤治疗。此证不可使用攻下法，因为邪气完全盛发于体表和经络，若用攻下法会导致表邪内陷，从而出现额头少量出汗、手足逆冷的症状。尤其不可使用发汗法，因为邪气本属热邪，发汗会进一步增加热势，从而导致心中烦闷混乱，反而加重胡言乱语。只有使用白虎汤清除其浮越的热邪，如果另外兼有燥屎结聚、腹痛等症状，可以在本方中加入大黄进行攻下。
时疫出现的囊缩（阴囊收缩），是热邪侵入厥阴经所致。如果有结聚且有热，则采用攻下法；如果仅有热而无结聚，则采用清热法，热退后阴囊自然舒展。阴证引起的囊缩与时疫引起的囊缩颇为相似，因为阴证囊缩必然伴有身体寒冷、四肢厥冷、脉象沉伏，时疫囊缩也表现为身体寒冷、四肢厥冷、脉象沉伏。然而，一为寒证、一为热证，自有不同之处。阴证囊缩表现为阴茎萎缩，甚至完全缩入腹中，状如妇人；时疫热厥导致的囊缩，阴茎形态如常。再通过兼症来辨别：阴证囊缩者小便清长，少腹牵引作痛但腹部不胀满，喜欢温热按压，多伴有自发性腹泻，神志清醒且不烦躁；时疫囊缩者小便赤红，少腹胀满且硬痛拒按，大便秘结，烦躁且神志昏蒙。
In epidemic febrile diseases (Epidemic Febrile Disease) caused by damp-heat, cases with polyuria are rare. After the pathogen transmits inward, polyuria may occasionally occur; this is due to the stomach earth transforming into dryness-heat, and urgent purgation should be employed. If polyuria persists after repeated purgations, it indicates Qi deficiency, and treatment should focus on tonifying Qi and raising Yang. There are also cases of polyuria due to Kidney deficiency, treated with Liuwei Dihuang Tang (Six-Ingredient Rehmannia Decoction) added with Wuweizi (Schisandrae Fructus). Generally, before purgation, polyuria belongs to dryness-heat syndrome; the urine must be slightly yellow, accompanied by vexatious heat, thirst, and a desire to drink. After purgation, polyuria belongs to deficiency syndromes. In Qi deficiency, there is no desire to drink, and the Cun pulse is weaker than the Chi pulse, with the superficial pulse being weaker than the deep pulse; in Yin deficiency, there is a desire to drink, and the Chi pulse is weaker than the Cun pulse, with the deep pulse being weaker than the superficial pulse. If untreated for a long time, it may transform into Xiao Ke (Wasting-Thirst Syndrome). This describes polyuria in epidemic febrile diseases. As for polyuria caused by wind-cold, it belongs to Yang deficiency and is not included in this discussion.
Polyuria occurring at the initial stage of epidemic febrile disease mostly belongs to San Yang He Bing (Combined Disease of the Three Yang Channels). When the pathogen enters the Yang channels, Yang becomes excess and Yin becomes deficient. Heat is intense on the exterior, causing the interior to lose its control. Additionally, with mental confusion in the upper jiao, the patient is unaware of the discharge from the lower orifices, resulting in enuresis. If this condition is combined with abdominal fullness, body heaviness, inability to taste properly, dirty facial complexion, and delirium, Zhang Zhongjing advocates using Baihu Tang (White Tiger Decoction) exclusively. This condition should not be treated with purgation because the pathogen is fully abundant in the exterior and meridians; purging would cause the exterior pathogen to sink inward, leading to slight sweating on the forehead and cold extremities. It is especially inadvisable to use diaphoresis (sweating method), as the pathogen is inherently heat; sweating would increase the heat, causing mental restlessness and worsening delirium. One should only use Baihu Tang to clear the floating and overflowing heat. If additionally complicated by dryness accumulation and pain, Dahuang (Rhei Radix et Rhizoma) can be added to the base decoction for purgation.
Scrotal retraction (Nuo Suo) in epidemic febrile disease results from heat entering the Jueyin channel. If there is both accumulation and heat, purgation is used; if there is heat without accumulation, clearing heat is used. Once the heat subsides, the scrotum naturally relaxes. Scrotal retraction in Yin syndromes is quite similar to that in epidemic febrile diseases, as both present with cold body, cold extremities, and a deep pulse. However, one is cold and the other is hot, so they differ. In Yin syndrome scrotal retraction, the penis shrinks or completely retracts into the abdomen, resembling a woman's anatomy; in epidemic heat-jue scrotal retraction, the penis remains normal in shape. Differentiation can further be made through accompanying symptoms: in Yin syndrome scrotal retraction, urination is clear, the lower abdomen pulls and hurts but is not full, prefers warmth and pressure, often accompanied by spontaneous diarrhea, with clear consciousness and no vexation; in epidemic scrotal retraction, urination is red, the lower abdomen is full, hard, painful, and rejects pressure, stool is constipated, and the patient is vexed with confused consciousness.