帝曰∶时有间二日，或至数日发，或渴或不渴，其故何也？岐伯曰∶其间日者，邪气与卫气客于六腑，而
有时相失，不能相得，故休数日乃作也。疟者，阴阳更
胜也，或甚或不甚，故或渴或不渴。
疟邪在阴则静，遇阳则动。腑居身中阴分，邪客于腑，与卫阳有时相失而不遇，故间二日或数日一发，
名为三阴疟也。盖卫气行于阳，其气旺，行于阴，其气衰，不能冲动邪气，邪气蓄积数日，与元气俱旺，则病
发。故邪在阳分则浅而从汗泄，为易愈；邪在阴分则深，为难愈也。邪乘阳则热，热甚则渴，不甚亦不渴；
邪乘阴，不热而不渴；或乘阳而挟湿邪，虽热亦多不渴，或口燥而不欲饮者，湿遏阳气，津液不升也。
帝曰∶论言夏伤于暑，秋必病疟。今疟不必应者，何也？岐伯曰∶此应四时者也。其病异形者，反四时也。
其以秋病者寒甚，以冬病者寒不甚，以春病者恶风，以夏病者多汗。
疟有不必定发于秋，与论言不相应者，盖四时之气，皆能成疟也。如春风、夏暑、秋凉、冬寒，四时之气
也。其病有异形者，与四时之气相反也。如秋应凉而反热，春应温而反大寒，此其气异，而病亦异，乃变成疟
也。然春为风木主令，其发疟也，则必恶风；夏令阳气发泄，其病疟也，则必多汗。此其病形虽异，而气之升
降浮沉，仍有次序可验。以疟者由伏邪所发，夏令发泄，感邪不觉，至秋外寒骤加，而内邪不容，则必病发，
故论言之也。其三时之气不反，则感邪即病，少有成疟者，故论独举夏伤暑，秋病疟也。其三时之气不反而有
伏邪者，如冬伤于寒，春必病温等，已另有明文矣。
黄帝问道：疟疾有时隔两天发作，或者间隔几天才发作，有的口渴，有的不口渴，这是什么缘故呢？岐伯回答说：那些隔日发作的，是因为邪气与卫气都客居于六腑，但两者有时不能相遇，无法相互感应，所以要经过几天才能发作。疟疾这种病，是阴阳之气交替胜复的结果，如果偏盛得厉害就不轻，偏盛得不厉害就不重，所以有的口渴，有的不口渴。
疟邪在阴分则静止，遇到阳分则活动。六腑位于身体中的阴分部位，邪气客居在腑中，与卫阳之气有时不能相遇，所以隔两天或几天发作一次，这叫做三阴疟。大概卫气运行于阳分时，其气旺盛；运行于阴分时，其气衰弱，不能冲动邪气。邪气蓄积几天，等到人体元气也旺盛时，疾病才会发作。所以邪气在阳分则病位浅，容易通过发汗排出，属于容易治愈的；邪气在阴分则病位深，难以治愈。邪气侵犯阳分则发热，热势严重就会口渴，热势不严重也就不口渴；邪气侵犯阴分，既不发热也不口渴；或者邪气侵犯阳分兼夹湿邪，虽然发热但也大多不口渴，或者口干舌燥但不想喝水，这是因为湿气遏制了阳气，导致津液不能上升。
黄帝问道：医论中说夏天感受暑邪，秋天必定患疟疾。现在疟疾不一定对应这个规律，是什么原因呢？岐伯回答说：这是符合四时气候变化的。病情表现不同的，是与四时气候相反的。在秋天发病的，寒邪较重；在冬天发病的，寒邪较轻；在春天发病的，怕风；在夏天发病的，多汗。
疟疾不一定定在秋天发作，与医论所说的不相符，大概是因为四季的气候都能形成疟疾。如春风、夏暑、秋凉、冬寒，这些都是四时之气。病情表现不同的，是与四时之气相反的情况。比如秋天本该凉爽却反而炎热，春天本该温暖却反而大寒，这些气候异常，疾病也随之不同，于是变成了疟疾。然而春季由风木主令，发作疟疾时，必然怕风；夏季阳气发泄，患病疟疾时，必然多汗。这些病情表现虽然不同，但气的升降浮沉，仍然有次序可以验证。因为疟疾是由伏邪引发的，夏季阳气发泄，感受邪气时没有察觉，到了秋天外来的寒气突然加重，体内的邪气无法容纳，就一定会发病，所以医论这样说了。其他三个季节的气候如果不反常，那么感受邪气就会立即发病，很少形成伏邪致疟的情况，所以医论单独举出“夏伤于暑，秋必病疟”这一条。其他三个季节气候不反常但有伏邪的情况，如冬天感受寒邪，春天必定患温病等，已经在别处有明确的文字说明了。
The Yellow Emperor asked: Sometimes malaria occurs every two days, or even after several days; some patients feel thirsty, while others do not. What is the reason for this? Qibo replied: In cases of intermittent occurrence, the pathogenic factor and Wei Qi (Defensive Qi) reside in the Six Fu Organs (Six Yang Organs), but they sometimes fail to meet and interact, thus requiring several days before an attack occurs. Malaria is characterized by the alternating dominance of Yin and Yang. If the imbalance is severe, symptoms are pronounced; if mild, symptoms are less so. Hence, some patients experience thirst, while others do not.
When the malaria pathogen resides in the Yin aspect, it remains static; when it encounters the Yang aspect, it becomes active. The Fu organs are located in the Yin portion of the body. When the pathogen lodges in the Fu organs, it fails to encounter Wei Yang (Defensive Yang) at certain times, resulting in attacks occurring every two days or every few days. This is termed San Yin Malaria (Malaria involving the Three Yin aspects). Generally, when Wei Qi circulates in the Yang aspect, its energy is vigorous; when it circulates in the Yin aspect, its energy is weak, failing to stir up the pathogen. The pathogen accumulates over several days until the Yuan Qi (Original Qi) also becomes vigorous, at which point the disease manifests. Therefore, when the pathogen is in the Yang aspect, the condition is superficial and can be easily resolved through sweating, making it easier to cure; when the pathogen is in the Yin aspect, the condition is deep and difficult to cure. When the pathogen affects the Yang aspect, heat is generated; if the heat is intense, thirst ensues; if not intense, there is no thirst. When the pathogen affects the Yin aspect, there is neither heat nor thirst. Alternatively, if the pathogen affects the Yang aspect but is accompanied by Dampness, although heat may be present, thirst is often absent; or there may be dryness in the mouth without desire to drink, due to Dampness restraining Yang Qi and preventing the ascent of Body Fluids.
The Yellow Emperor asked: The medical texts state that summer injury by Summer-heat leads to autumn malaria. Why does malaria not always correspond to this rule? Qibo replied: This corresponds to the Four Seasons. Cases presenting with atypical forms contradict the general seasonal pattern. Those manifesting in autumn involve severe cold; those in winter involve mild cold; those in spring involve aversion to wind; and those in summer involve profuse sweating.
Malaria does not necessarily occur only in autumn, appearing inconsistent with the texts, because the Qi of all four seasons can induce malaria. These include Spring Wind, Summer Summer-heat, Autumn Coolness, and Winter Cold—the Qi of the four seasons. Atypical presentations arise from contradictions with the normal seasonal Qi. For instance, if autumn should be cool but is instead hot, or spring should be warm but is severely cold, such abnormal Qi leads to different diseases, thereby transforming into malaria. However, since Spring is governed by Wind-Wood, malaria arising in spring must involve aversion to wind; during Summer, when Yang Qi is released, malaria must involve profuse sweating. Although these clinical forms differ, the rising, descending, floating, and sinking of Qi still follow a verifiable order. Since malaria originates from latent pathogens, during summer when Yang Qi is released, infection occurs unnoticed. By autumn, sudden external cold prevents the internal latent pathogen from remaining contained, triggering the disease. Thus, the texts emphasize this pattern. In the other three seasons, if the Qi is not abnormal, illness occurs immediately upon infection, rarely forming latent malaria. Therefore, the texts specifically highlight "summer injury by Summer-heat leading to autumn malaria." Regarding latent pathogens in the other three seasons despite non-abnormal Qi, such as winter injury by Cold leading to spring Warmth diseases, these have already been explicitly detailed elsewhere.