孔子曰∶精义入神，以致用也。医药之道，苟不精义，致用也难矣。其观象索本，知几
通变，非天下至精，孰能与于此哉？仲景氏出，方法悉备，其书虽存，而知意味者鲜矣。于
是治疾之要，唯知随证，而不知观证之有法也。其论药能方验药功，混为一，终不辨本性也。
如斯而得入神，孰不为良医耶？村井大年，肥后人也，笃信吾先考东洞翁。治旧 ，起废疾，
名声振四海。顷者集《药征》不载之药品，稽古征今，审其功能，作《药征续编》，大年之
精斯道也。读此书而观其所论，则可知焉。
宽政丙辰仲冬平安吉益猷修夫序
桃花汤证曰∶下利便脓血。
赤石脂禹余粮汤证曰∶下利不止。
上二方，赤石脂各一斤。
乌头赤石脂丸，证不具。
上一方，赤石脂一两。
据此三方，则赤石脂，治水毒下利不止便脓血明矣。
赤石脂配干姜，则治腹痛下利。若无腹痛，则不配干姜。
乌头赤石脂丸，证不具。但云治心痛彻背，背痛彻心者，虽然，此方岂惟治心背彻痛乎？
后世误载之《金匮要略·心痛》病篇内。故世医皆以为但治心痛之方也。 按∶此方本当在
六经病篇内，某证条下，而治心痛彻背，背痛彻心者矣。今详前后之条，及病证方法，盖厥
阴病，蛔厥，心痛彻背，背痛彻心，下利恶寒者主之。当是同甘草粉蜜汤，大建中汤等，在
乌梅丸之前后矣。《外台秘要》第七心背彻痛方内曰∶仲景《伤寒论》，心痛彻背，背痛彻心，
乌头赤石脂丸主之。小注云∶出第十五卷中。然则是本《伤寒论·蒸阴病》篇内方，而必有
前后之证存矣。何以言之？则蜀椒治蛔厥。干姜治下利腹痛，乌头、附子，并治四肢厥逆，
赤石脂惟治下利。由此观之，此方岂惟治心背彻痛乎？余尝疑乌梅能治蛔，故蛔厥心痛彻背，
背痛彻心，则此方不可无乌梅矣。然则乌头是乌梅之误矣乎？凡仲景之方，无乌头、附子并
用者，则益知乌头是乌梅之误矣。 又按∶《外台秘要》第七久心痛方内，有范汪疗久心痛
方，又名乌头赤石脂丸。方内有桂心，（桂心即桂枝，唐方皆以桂枝为桂心）无附子，此为
异
耳。或疑附子是桂枝之误矣乎？桂枝能治上冲而厥者，乌头、附子，本同物同功，并存以俟
明者试效而已。
桃花汤方曰∶赤石脂一斤，一半全用，一半筛末，是分赤石脂一斤以为各半斤。干姜一
两，粳米一升，以水七升，煮米令熟，去滓，取七合，又取半斤赤石脂末内方寸匕，温服，
一日三服。后内赤石脂末方寸匕者，未知何故也，宜随仲景之法施之。《外台秘要》引崔氏
方，阮氏桃花汤，分两法，则与此不同，可考。
孔子说：“探究事物的精微义理以达到神妙的境界，是为了实际应用。”医药之道，如果不精通其精微义理，想要应用于实践是很难的。那些观察表象以探求本源、知晓细微变化而通晓变通的道理，如果不是天下最精妙的人，谁能做到这一点呢？张仲景出现后，治疗方法全部具备，虽然他的书还存世，但能领会其中意味的人很少了。于是治疗疾病的关键，只知道随证施治，却不知道观察病症是有法则的。他们讨论药物的性能、方剂的功效和验证药功时，混杂在一起，始终不辨析药物的本性。像这样就能达到神妙的境界，谁不能成为良医呢？村井大年，是肥后人，深信我的先父东洞先生。他治愈旧疾，起死回生，名声震动四海。近来他收集《药征》未收录的药物，考证古今，审慎考察其功能，编写了《药征续编》，这体现了大年在医学上的精深造诣。读这本书并观看他的论述，就可以知道了。
宽政丙辰年（1796年）仲冬，平安吉益猷作序。
桃花汤证的症状描述为：下利且大便带脓血。
赤石脂禹余粮汤证的症状描述为：下利不止。
上述两个方剂中，赤石脂各用一斤。
乌头赤石脂丸，其对应的证候描述不完整。
上述一个方剂中，赤石脂用一两。
根据这三个方剂来看，赤石脂治疗水毒引起的下利不止和大便带脓血是明确的。
赤石脂配伍干姜，则治疗腹痛下利。如果没有腹痛，就不配伍干姜。
乌头赤石脂丸，其对应的证候描述不完整。只说治疗心痛放射至背部、背痛放射至心口的患者，虽然如此，这个方子难道只是治疗心背相互牵引疼痛的吗？后世错误地将其记载在《金匮要略·心痛》病篇内。所以世间的医生都以为这是只治疗心痛的方子。按：此方原本应该在六经病篇内，某个证候条目的下方，用于治疗心痛放射至背部、背痛放射至心口的患者。现在详细查看前后的条文及病证方法，大概是厥阴病，蛔厥，心痛放射至背部、背痛放射至心口，伴有下利恶寒的患者主用此方。应当是与甘草粉蜜汤、大建中汤等一样，位于乌梅丸的前后位置。《外台秘要》第七卷心背相互牵引疼痛方内记载：张仲景《伤寒论》中，心痛放射至背部、背痛放射至心口，用乌头赤石脂丸主治。小注云：出自第十五卷中。然而这本是《伤寒论·厥阴病》篇内的方子，必然有前后的证候记载存在。为什么这样说呢？因为蜀椒治疗蛔厥，干姜治疗下利腹痛，乌头、附子共同治疗四肢厥逆，赤石脂只治疗下利。由此看来，这个方子难道只是治疗心背相互牵引疼痛吗？我曾经怀疑乌梅能治疗蛔虫，所以如果蛔厥导致心痛放射至背部、背痛放射至心口，那么这个方子不可没有乌梅。那么乌头是乌梅的误写吗？凡是张仲景的方剂，没有乌头和附子同时使用的情况，这就更加知道乌头是乌梅的误写了。又按：《外台秘要》第七卷久心痛方内，有范汪治疗久心痛的方子，又名乌头赤石脂丸。方内有桂心（桂心即桂枝，唐代方剂都以桂枝为桂心），没有附子，这是不同之处。有人怀疑附子是桂枝的误写吗？桂枝能治疗气上冲而厥逆的情况，乌头、附子本来同物同功，并存是为了等待明眼人试验效果而已。
桃花汤方记载：赤石脂一斤，一半全用，一半研成粉末，是将一斤赤石脂分为各半斤。干姜一两，粳米一升，用水七升，煮米令熟，去渣，取七合，再取半斤赤石脂末，每次一方寸匕，温服，一日三次。后面提到的加入赤石脂末一方寸匕，不知道是什么原因，应该遵循张仲景的方法施行。《外台秘要》引用崔氏方、阮氏桃花汤的分量方法，与此不同，可以考证。
Confucius said, "Penetrating the subtle principles to reach a state of divine efficacy is for the purpose of practical application." In the way of medicine and pharmacology, if one does not master these subtle principles, it will be difficult to apply them in practice. To observe phenomena to seek their roots, and to understand subtle changes and adapt accordingly—only those who are the most refined in the world can achieve this? When Zhang Zhongjing appeared, all methods were complete. Although his books still exist, few people understand their profound meaning. Consequently, the key to treating diseases has become merely knowing how to treat according to symptoms, without understanding that observing symptoms follows specific laws. Their discussions on drug properties, formula efficacy, and verification of medicinal effects are mixed together, never distinguishing the inherent nature of the drugs. If one can reach such a state of divine efficacy in this manner, who would not become a good physician? Murai Taishō, from Higo Province, firmly believed in my late father, Mr. Dōtō. He cured chronic illnesses and revived the critically ill, spreading his fame across the four seas. Recently, he collected medicinal materials not included in *Yao Zheng* (Record of Medicinal Properties), examined ancient texts and current practices, carefully assessed their functions, and compiled *Yao Zheng Xu Bian* (Continued Record of Medicinal Properties). This demonstrates Taishō's profound mastery of this path. By reading this book and observing his discussions, one can know this.
Preface by Yasuyoshi Yū of Heian, Mid-winter of Bingchen Year of Kansei (1796).
Chishizhi (Red Halloysite) primarily treats diarrhea caused by water toxicity. Therefore, it also treats dysentery with pus and blood in the stool.
The syndrome for Taohua Tang (Peach Blossom Decoction) states: Diarrhea with pus and blood in the stool.
The syndrome for Chishizhi Yuyuliang Tang (Red Halloysite and Hematite Decoction) states: Unremitting diarrhea.
In the above two formulas, Chishizhi (Red Halloysite) is used in amounts of one jin each.
For Wutou Chishizhi Wan (Aconite Root and Red Halloysite Pill), the corresponding syndrome description is incomplete.
In the above single formula, Chishizhi (Red Halloysite) is used in an amount of one liang.
Based on these three formulas, it is clear that Chishizhi (Red Halloysite) treats unremitting diarrhea and dysentery with pus and blood caused by water toxicity.
When Chishizhi (Red Halloysite) is combined with Ganjiang (Dried Ginger), it treats abdominal pain and diarrhea. If there is no abdominal pain, it is not combined with Ganjiang (Dried Ginger).
For Wutou Chishizhi Wan (Aconite Root and Red Halloysite Pill), the syndrome description is incomplete. It only mentions treating patients with heart pain radiating to the back and back pain radiating to the heart. Although so, does this formula only treat pain radiating between the heart and back? Later generations erroneously recorded it in the "Heart Pain" disease chapter of *Jingui Yaolue* (Essential Prescriptions of the Golden Cabinet). Thus, physicians of the world believe it is a formula solely for treating heart pain. According to analysis: This formula should originally have been in the Six Channels Disease chapters, under a specific syndrome entry, for treating heart pain radiating to the back and back pain radiating to the heart. Now, examining the preceding and following clauses and disease-syndrome methods, it seems to be for Jueyin Disease (Disease of the Jueyin Channel), Huijue (Roundworm Cold Syndrome), where heart pain radiates to the back and back pain radiates to the heart, accompanied by diarrhea and aversion to cold. It should be placed before and after Wu Mei Wan (Mume Pill), similar to Gancao Fenmi Tang (Licorice and Flour Honey Decoction) and Dajianzhong Tang (Greatly Build the Middle Decoction). *Waitai Miyao* (Secret Essentials of the Outer Palace), Volume 7, in the section on heart-back radiating pain, states: In Zhang Zhongjing's *Shanghan Lun* (Treatise on Cold Damage), for heart pain radiating to the back and back pain radiating to the heart, Wutou Chishizhi Wan (Aconite Root and Red Halloysite Pill) is the primary treatment. The small note says: Originates from Volume 15. However, this is a formula from the *Shanghan Lun* Jueyin Disease chapter, and there must have been preceding and following syndrome descriptions. Why do I say this? Because Shujiao (Sichuan Pepper) treats Huijue (Roundworm Cold Syndrome); Ganjiang (Dried Ginger) treats diarrhea and abdominal pain; Wutou (Radix Aconiti Lateralis Preparata) and Fuzi (Radix Aconiti Lateralis Preparata) jointly treat limb coldness and reversal (Jue Ni); Chishizhi (Red Halloysite) only treats diarrhea. From this perspective, does this formula only treat pain radiating between the heart and back? I once suspected that Wumei (Fructus Mume) could treat roundworms. Therefore, if Huijue (Roundworm Cold Syndrome) causes heart pain radiating to the back and back pain radiating to the heart, this formula cannot lack Wumei (Fructus Mume). Then, is Wutou (Radix Aconiti Lateralis Preparata) a miswriting for Wumei (Fructus Mume)? In all of Zhang Zhongjing's formulas, Wutou (Radix Aconiti Lateralis Preparata) and Fuzi (Radix Aconiti Lateralis Preparata) are never used together. This further confirms that Wutou (Radix Aconiti Lateralis Preparata) is a miswriting for Wumei (Fructus Mume). Furthermore, according to *Waitai Miyao* (Secret Essentials of the Outer Palace), Volume 7, in the Chronic Heart Pain section, there is Fan Wang's formula for chronic heart pain, also named Wutou Chishizhi Wan (Aconite Root and Red Halloysite Pill). This formula contains Guixin (Cinnamon Twig Bark, i.e., Guizhi/Cinnamon Twig; Tang dynasty formulas referred to Guizhi as Guixin) but lacks Fuzi (Radix Aconiti Lateralis Preparata); this is the difference. Some suspect that Fuzi (Radix Aconiti Lateralis Preparata) is a miswriting for Guizhi (Cinnamon Twig). Guizhi (Cinnamon Twig) can treat upward rushing Qi leading to Jue Ni (Cold Reversal). Wutou (Radix Aconiti Lateralis Preparata) and Fuzi (Radix Aconiti Lateralis Preparata) originate from the same source and have identical functions; they are preserved side-by-side awaiting experts to test their efficacy.
The Taohua Tang (Peach Blossom Decoction) formula states: Chishizhi (Red Halloysite) one jin, half used whole, half sifted into powder; this divides one jin of Chishizhi (Red Halloysite) into two halves of half a jin each. Ganjiang (Dried Ginger) one liang, Jingmi (Oryza Sativa Germen, Rice) one sheng. Boil in seven sheng of water until the rice is cooked, remove the dregs, take seven ge. Then add half a jin of Chishizhi (Red Halloysite) powder, one fangcun bi per dose, taken warm, three times a day. Regarding the later instruction to add Chishizhi (Red Halloysite) powder, one fangcun bi, the reason is unknown; one should follow Zhang Zhongjing's method for administration. *Waitai Miyao* (Secret Essentials of the Outer Palace) cites Cui Shi's formula and Ruan Shi's Taohua Tang (Peach Blossom Decoction) dosage methods, which differ from this; this can be verified.