济世之道，莫先于医，医术多途，莫险于痘，稽种痘之说，上古未有，自汉代伏波将军
，征武陵蛮，从壶中进兵，军中遂染此疾，厥后班师，毒瓦斯传入中国。诸医调治，皆据《内
经》痛痒疮疡属心火之一言，为治痘之要领，十损八九。及至宋仁宗时，丞相王旦，初生诸
子，俱死于痘。后老年生一子名素，欲为出痘，招集天下诸医有能深明治痘之法及着书立说
者，重金酬谢。诸医皆言不敢深明于痘。川人闻其求医甚殷，乃为延请天姥仙娘，现身说法
，取痘苗絮于鼻孔，旬日之外，告厥成功。嗣是相传三桥善女，痘症日渐通行。然或有感天
气而发者，或有取苗吹入鼻孔而发者，顺则易治，逆则难医，甚至凭于危亡而勿可救药。俾
天下赤子，罹此害者，不可胜计。儒窃悯之！
壬午冬，清邑族君天池，延嘉禾邑庠生李翘楚为孙童种痘，适儒医业是邑，闻其术不劳
而效甚大，一日邀游界溪市寓，聚谈之次，论及此事。始云拣选佳苗，剔取鲜浆，披点人身
两臂消烁、夹白、清冷渊穴，所按日期，与吹鼻无异。寻其源，则来自西洋，传自邱熹，效
捷功深，名公钜卿，多有投赠。族戚好善诸公，以儒习此，宜广行其术，儒怀疑观望，而不
敢妄进焉。癸未春，清邑点种通行，因再为之反复详观，果于所刺之处，红晕鲜活，坟起如
痘，以痘证书，果如其言，种种吹、染、全无复出。夫乃叹荷圣天子洪休，引外洋之奇方，
传留中国，跻人生于寿域矣。于是谋之族君恭寅，同学是术，传点千百小儿，俱有真验。第
虑版存东粤，路途迢遥，题咏方书，难于传遍，今幸本省大人深仁浓泽，爱民如子，刊版通
行，将千载流传，永为万民攸赖，敢不捧稿恭呈，而详为之序。衡山吴珍儒。
救治世人的道理，没有比医学更优先的了；医术的途径很多，但没有比痘症（天花）更险恶的了。考察种痘的说法，上古时代并没有，自从汉代伏波将军马援征讨武陵蛮族时，从壶中出兵，军中于是染上了这种疾病，后来军队撤回，毒气传入中国。各位医生进行治疗，都依据《黄帝内经》中“痛痒疮疡属于心火”这一句话，作为治疗痘症的要点，结果十有八九造成损伤。到了宋仁宗时期，丞相王旦，他最初生的几个儿子，都死于痘症。后来他在老年时生了一个儿子叫王素，想要让他出痘，召集天下所有精通治疗痘症方法以及著书立说的医生，给予重金酬谢。各位医生都说不敢声称精通痘症。四川人听说他求医非常殷切，于是为他聘请了天姥仙娘，现身说法，取痘苗絮塞入鼻孔，十天之后，宣告成功。从此以后相传三桥善女，痘症逐渐通行。然而有的因感受天气而发作，有的因取苗吹入鼻孔而发作，顺证则容易治疗，逆证则难以医治，甚至导致危亡而无法挽救。使得天下的婴儿，遭受这种灾害的，不可胜数。我私下对此感到怜悯！
壬午年冬天，清邑的族君天池，邀请嘉禾县的秀才李翘楚为他的孙子儿童种痘，恰逢我也行医在这个县，听说这种方法不费力且效果很大，一天邀请我到界溪市的寓所聚会交谈，在谈论之间，论及此事。才开始说挑选优良的痘苗，剔取新鲜的浆液，点刺人体两臂的消烁、夹白、清冷渊穴位，所按压的日期，与吹鼻法没有不同。追溯其源头，则是来自西洋，由邱熹传播，见效快功效深，名公巨卿多有投赠。同族亲戚中喜好行善的各位先生，认为我学习此术，应该广泛推行，我内心怀疑观望，而不敢妄自进用。癸未年春天，清邑点种法通行，因此再次为我反复详细观察，果然在所刺的地方，红晕鲜活，隆起如痘，用痘症来验证，确实像他们说的那样，种种吹、染的方法，完全没有再复发。这才感叹承蒙圣天子巨大的福泽，引进外洋的奇方，流传留在中国，使人生于长寿之境。于是与族君恭寅商量，共同学习此术，传授点种给千百个小儿，都有真实的验证。只是担心刻版在东粤，路途遥远，题咏方书，难以传遍，如今幸得本省大官仁爱深厚，爱民如子，刊刻版印通行，将千年的流传，永远成为万民依赖的保障，怎敢不捧着稿件恭敬呈上，并详细为之作序。衡山人吴珍儒。
The way to save the world begins with medicine; among various medical practices, none is more perilous than smallpox (Xiaochu). Examining the theory of variolation, it did not exist in ancient times. It originated when General Ma Yuan, the Marquis of Bowu, campaigned against the Wuling barbarians. The troops contracted this disease from a gourd vessel used in battle. Upon their return, the pathogen spread into China. Physicians at the time treated it based on a statement from *Huangdi Neijing* (Yellow Emperor's Inner Canon): "Pain, itching, sores, and ulcers belong to Heart Fire." They took this as the key principle for treating smallpox, resulting in eight or nine out of ten cases suffering severe damage.
During the reign of Emperor Renzong of Song, Chancellor Wang Dan’s initial sons all died of smallpox. Later in life, he had a son named Wang Su and wished for him to undergo natural infection. He gathered physicians from across the country who claimed deep expertise in smallpox treatment and authored relevant texts, offering heavy rewards. However, all physicians stated they dared not claim mastery over smallpox. Hearing of his urgent need, people from Sichuan invited Tianmu Xianniang (Fairy Lady of Tianmu), who demonstrated the method by inserting smallpox matter into the nostrils. Ten days later, success was declared. Thereafter, the method propagated through Sanqiao Shannü, and smallpox inoculation became common. Some cases arose from exposure to weather conditions, while others resulted from nasal insufflation. Favorable cases were easy to treat, but adverse ones were difficult to manage, sometimes leading to critical danger and death beyond remedy. Consequently, countless infants suffered from this affliction. I privately felt pity for them!
In the winter of the Renwu year, Zu Jun Tianchi from Qingyi invited Li Qiaochu, a Xiucai (scholar) from Jiahe County, to perform variolation on his grandson. At that time, I was practicing medicine in that county. Hearing that this technique was effortless yet highly effective, I was invited one day to a gathering at an inn in Jiexi Market. During our conversation, we discussed this matter. It was then explained that excellent smallpox material is selected, fresh pus is extracted, and the Xiaoshuo, Jiabai, and Qinglengyuan acupoints on both arms are punctured. The timing corresponds closely to the nasal insufflation method. Tracing its origin, this practice came from the Western Regions and was transmitted by Qiu Xi. It acts swiftly and profoundly, receiving gifts and commendations from high-ranking officials. Kind-hearted relatives and friends, knowing I had learned this art, urged me to promote it widely. However, I remained skeptical and hesitant, daring not to proceed rashly.
In the spring of the Guiwei year, variolation became widespread in Qingyi. I observed it repeatedly and found that at the puncture sites, red halos appeared vividly, swelling up like true smallpox lesions. Verification against smallpox symptoms confirmed their claims: various methods of insufflation and contamination showed no recurrence. Only then did I sigh, grateful for the Great Emperor’s benevolence, which introduced this miraculous foreign prescription to China, bringing longevity to humanity. I then consulted with Zu Jun Gongyin, who also learned this technique. We taught variolation to thousands of children, achieving genuine results. However, fearing that printing plates stored in Dongyue would be too distant for wide distribution, and that written records might not spread easily, I am fortunate that the provincial authorities possess profound benevolence, loving the people as their own children. They have commissioned the printing and circulation of these texts, ensuring that this millennium-old knowledge becomes a permanent reliance for all people. How could I dare not present this manuscript respectfully and provide a detailed preface? Wu Zhenru from Hengshan.