治血气涩滞，手足拘挛，风寒湿痹等疾。
川续断 杜仲（去皮，姜炒） 防风 桂心 人参 茯苓 生地黄 白芍药 甘草
川芎 当归 黄 川牛膝 川独活 细辛 秦艽（各等分） 加姜枣煎。
此足三阴药也。喻嘉言曰∶此方用参 四物，一派补药，内于防风、秦艽以胜风
湿，桂心以胜寒，细辛、独活以通肾气，凡治三气袭虚而成痹，患者宜准诸此。
治肝肾虚热，风湿内攻，腰膝作痛冷痹症，及屈伸不便。肾水脏也，虚则寒湿之气
凑之，故腰膝作实而痛。冷痹者，阴邪胜也，肝主筋肾主背，《灵枢》曰∶能屈而不
能伸者，病在筋；能伸而不能屈者，病在骨。
独活 桑寄生（如无真者，以川续断代之） 秦艽 防风 熟地黄 当归（酒洗）
芍药（酒炒） 川芎（酒洗） 杜仲（姜汁炒断丝） 牛膝 人参 茯苓 甘草 桂
心细辛（等分） 每服四钱。此即前方除黄 、续断，加桑寄生，此足少阴厥阴药也。
独活、细辛入少阴，通血脉，偕秦艽、防风，疏经升阳，以祛风；桑寄生益气血，祛
风湿，偕杜仲、牛膝，健骨强筋而固下；芎归芍地，所以活血而补阴；参桂苓草，所以
益气而补阳。辛温以散之，甘温以补之，使血气足而风湿除，则肝肾强而痹痛愈矣。丹
溪曰∶久腰痛必用官桂以开之，腹胁痛亦然。
治疗气血运行涩滞不畅，手足拘急挛缩，以及风寒湿邪侵袭导致的痹证等疾病。
川续断、杜仲（去除外皮，用姜汁炒制）、防风、桂心、人参、茯苓、生地黄、白芍药、甘草、川芎、当归、黄芪、川牛膝、川独活、细辛、秦艽（以上药材各取等量分量），加入生姜和大枣煎煮服用。
此方属于调理足三阴经（足太阴脾经、足少阴肾经、足厥阴肝经）的药物组合。喻嘉言说：此方用人参和四物汤（由熟地黄、当归、白芍、川芎组成，具有补血调血功效的方剂），全是一派补益药物，其中加入防风、秦艽以抵御风湿，桂心以抵御寒邪，细辛、独活以通达肾气。凡是治疗因风、寒、湿三气侵袭人体正气虚弱而形成的痹证，患者应当依据此法进行治疗。
治疗肝肾阴虚内热，风湿之邪向内攻冲，导致腰部和膝盖疼痛、冷痹症，以及关节屈伸不便的症状。肾属于水脏，肾虚则寒湿之气容易聚集于此，所以腰部感觉充实且疼痛。所谓冷痹，是因为阴寒邪气亢盛所致。肝主管筋脉，肾主管骨骼，《灵枢》中说：能够弯曲但不能伸展的，病在筋脉；能够伸展但不能弯曲的，病在骨骼。
独活、桑寄生（如果没有真品桑寄生，可以用川续断代替）、秦艽、防风、熟地黄、当归（用酒清洗）、芍药（用酒炒制）、川芎（用酒清洗）、杜仲（用姜汁炒至断丝）、牛膝、人参、茯苓、甘草、桂心、细辛（以上药材等量），每次服用四钱。这即是前方去掉黄芪、川续断，加上桑寄生而成，属于调理足少阴肾经和足厥阴肝经的药物。
独活、细辛进入足少阴肾经，通畅血脉，配合秦艽、防风，疏通经络、升发阳气，以祛除风邪；桑寄生补益气血、祛除风湿，配合杜仲、牛膝，强健骨骼、壮实筋脉并固护下焦；川芎、当归、白芍、熟地黄，用来活血并滋补阴血；人参、桂心、茯苓、甘草，用来益气并温补阳气。用辛温之性来发散邪气，用甘温之性来补益正气，使气血充足而风湿得以消除，那么肝肾功能强健，痹痛也就痊愈了。朱丹溪说：长期的腰痛必须使用官桂（肉桂的一种）来开通散结，腹部和胁部的疼痛也是如此。
Treats conditions characterized by sluggish stagnation of Qi and Blood, spasm and contracture of the hands and feet, and Bi syndrome (painful obstruction syndrome) caused by Wind-Cold-Dampness.
Xu Duan (Radix Dipsaci), Du Zhong (Cortex Eucommiae, peeled and stir-fried with ginger juice), Fang Feng (Radix Saposhnikoviae), Gui Xin (Cortex Cinnamomi), Ren Shen (Radix Ginseng), Fu Ling (Poria), Sheng Di Huang (Radix Rehmanniae Preparata), Bai Shao Yao (Radix Paeoniae Alba), Gan Cao (Radix Glycyrrhizae), Chuan Xiong (Rhizoma Chuanxiong), Dang Gui (Radix Angelicae Sinensis), Huang Qi (Radix Astragali), Chuan Niu Xi (Radix Cyathulae), Chuan Du Huo (Radix Angelicae Pubescentis), Xi Xin (Herba Asari), Qin Jiao (Radix Gentianae Macrophyllae) [all in equal proportions]. Decoct with fresh ginger and jujubes.
This formula acts on the Three Yin Meridians of the Foot (Spleen, Kidney, Liver). Yu Jiayan stated: This formula employs Ren Shen and Si Wu Tang (Four Substances Decoction, a classic blood-nourishing formula), consisting entirely of tonifying herbs. Within this, Fang Feng and Qin Jiao are used to overcome Wind-Dampness; Gui Xin to overcome Cold; Xi Xin and Du Huo to unblock Kidney Qi. For any Bi syndrome resulting from the invasion of Wind, Cold, and Dampness into a state of deficiency, patients should adhere to this principle.
Treats deficiency-heat of the Liver and Kidneys, internal attack by Wind-Dampness, pain and cold sensation in the lower back and knees (Cold Bi syndrome), and difficulty in flexion and extension. The Kidney is an organ of Water; when deficient, Cold-Dampness tends to gather there, causing a sensation of fullness and pain in the lower back and knees. "Cold Bi" refers to the predominance of Yin pathogenic factors. The Liver governs the sinews (tendons), and the Kidney governs the bones. The *Ling Shu* states: "If one can flex but not extend, the disease is in the sinews; if one can extend but not flex, the disease is in the bones."
Du Huo (Radix Angelicae Pubescentis), Sang Ji Sheng (Ramulus Taxilli) [if authentic Sang Ji Sheng is unavailable, substitute with Xu Duan], Qin Jiao (Radix Gentianae Macrophyllae), Fang Feng (Radix Saposhnikoviae), Shu Di Huang (Radix Rehmanniae Preparata), Dang Gui (Radix Angelicae Sinensis, washed with wine), Shao Yao (Radix Paeoniae, stir-fried with wine), Chuan Xiong (Rhizoma Chuanxiong, washed with wine), Du Zhong (Cortex Eucommiae, stir-fried with ginger juice until fibers break), Niu Xi (Radix Achyranthis Bidentatae), Ren Shen (Radix Ginseng), Fu Ling (Poria), Gan Cao (Radix Glycyrrhizae), Gui Xin (Cortex Cinnamomi), Xi Xin (Herba Asari) [in equal proportions]. Take 4 qian per dose. This is the previous formula minus Huang Qi and Xu Duan, plus Sang Ji Sheng. It acts on the Foot Shaoyin (Kidney) and Foot Jueyin (Liver) meridians.
Du Huo and Xi Xin enter the Foot Shaoyin meridian to unblock the vessels; accompanied by Qin Jiao and Fang Feng, they unblock the collaterals and raise Yang to dispel Wind. Sang Ji Sheng benefits Qi and Blood and dispels Wind-Dampness; accompanied by Du Zhong and Niu Xi, it strengthens the bones and sinews and secures the lower body. Chuan Xiong, Dang Gui, Bai Shao, and Shu Di Huang activate Blood and nourish Yin. Ren Shen, Gui Xin, Fu Ling, and Gan Cao benefit Qi and tonify Yang. Acrid-warm herbs disperse the pathogen; sweet-warm herbs tonify the healthy Qi. When Qi and Blood are sufficient and Wind-Dampness is eliminated, the Liver and Kidneys become strong, and Bi pain resolves. Zhu Danxi said: For chronic lower back pain, Guan Gui (a variety of Cinnamon Bark) must be used to open up stagnation; the same applies to abdominal and hypochondriac pain.