在发生各种失血之后，或因过度劳累、长期痢疾导致的各种虚损证候，如果再次出现发热症状，都属于不良的预后征象。凡是长期饮酒的人，若出现发热症状，难以治疗。如果不饮酒的人，因为饮酒而引发发热，也同样难以治疗。这是因为酒的性质大热且有毒，遇到体内原本阳气旺盛的身体，饮酒后热势会更加炽盛，导致阴气破散，阳气也随之消亡，所以难以治疗。然而，如果耗损尚未达到阳气亡脱的程度，或许还可以治疗。
凡是久病出现恶寒症状的，应当采用疏解郁滞的方法。凡是背部特别怕冷的，脉象浮大但无力的，这是阳气虚弱的表现。凡是面部发热却伴有恶寒症状的，这是寒气郁结导致内热的表现。大凡阳气虚弱的人大多会感到恶寒，适宜使用人参等药物，病情严重的，加入少许附子，以引导人参的药力运行。
After various types of hemorrhage, or following chronic fatigue and prolonged dysentery leading to various deficiency syndromes, the recurrence of fever indicates a poor prognosis. For individuals who consume alcohol, fever is difficult to treat. Even for non-drinkers, if fever is induced by alcohol consumption, it is also difficult to treat. This is because alcohol possesses a hot nature and toxicity; when encountered by a body with originally abundant Yang Qi, alcohol causes the heat to become even more intense, leading to the dispersion of Yin Qi and the exhaustion of Yang Qi, thus making treatment difficult. However, if the depletion has not reached the point of Yang Qi collapse, treatment may still be possible.
For chronic illnesses accompanied by aversion to cold, methods to resolve stagnation should be employed. Severe aversion to cold in the back, combined with a floating, large, but forceless pulse, indicates Yang Deficiency (Yang Xu). Facial heat accompanied by aversion to cold indicates Cold Stagnation transforming into Heat (Han Yu Re). Generally, those with Yang Deficiency often experience aversion to cold and are suitable for treatment with Ren Shen (Ginseng) and similar herbs. In severe cases, a small amount of Fu Zi (Aconite Lateral Root) should be added to guide the action of Ren Shen.