神治大行疫毒，大头诸病。
黄芩（酒炒） 黄连（酒炒，各五钱） 橘红 玄参 连翘 鼠粘子 板蓝根
马屁勃 生甘草 柴胡 桔梗 僵蚕（炒，各二钱） 新升麻（七分） 人参（三钱） 为末，汤调
服之。或蜜丸噙化。或有加防风、当归、川芎。加大便硬，加酒煨大黄利之；肿热甚
者，砭法刺之。
一方有薄荷一钱，无人参。
一方
治大头天行病，此为湿气在高巅之土，勿用降药。
羌活 酒芩 酒蒸大黄 水煎服。
又方
治大头疫如神。
贯众（三钱） 葛根（三钱） 甘草（一钱五分） 白僵蚕（一钱） 加黑豆，水煎服。
人中黄，解疫毒最妙，用甘草制造者，方见本草下。
《灵枢》曰∶手面与身形也。天寒则裂地凌冰，或手足懈堕，生而其面不衣何也？
曰∶十二经脉，三百六十五络，其血气皆上于面，而走空窍，其精阳气，上走于目而为
睛。其别气走于耳而为听，其宗气上出于鼻而为臭，其浊气出于胃，走唇舌而为味，其
气之津液，皆上熏于面，而皮又浓，其肉坚，故大热甚寒，不能胜之也。
东垣曰∶饮食不节则胃病，胃病则气
短，精神少而生大热，有时而火上，独疗其面，盖阳明经多气多血，又兼挟风热上行，
诸阳皆会于头面，故令面热如醉，治宜先为散其风热，或以调胃承气汤，加黄连犀角，
疏下两三行，彻其本热，散其风热，以升麻汤，加黄连主之。
手足六阳之经，皆生至于头，而惟阳明胃脉之鼻交额中，入上齿中，挟口环唇，循
颊车，上耳前，过客主人，故人之面部，阳明之所属也。其或胃中有热，有郁火则面
热，升麻汤加黄连。胃中有寒，则面寒，宜先以附子理中汤温其中气，次以升麻汤加附
子主之。若风热内甚而上攻，令人面目浮肿，或面鼻紫色，或风刺瘾疹随症治之。
面黄面白鼻冷，乃阳气大弱，宜大剂参 则附子主之。面痛为火，盖诸阳之汇，皆
在于面，而火阳也，心之华在面，而心君火也。然暴痛多由火实，久病多因血虚，盖胃
主正面，而以肠胃为市，因饮食之热毒聚于中，则发于外，故为痛，更有过劳与饥则痛
者，此中气不足也。
神功散主治严重的疫毒，以及大头瘟等病症。
黄芩（酒炒） 黄连（酒炒，各五钱） 橘红 玄参 连翘 鼠粘子（牛蒡子） 板蓝根
马屁勃（地锦草） 生甘草 柴胡 桔梗 僵蚕（炒，各二钱） 新升麻（七分） 人参（三钱） 研为细末，用汤药调服。或者制成蜜丸含化。有的方剂中加防风、当归、川芎。如果大便干硬，加酒煨大黄以通利大便；如果肿胀热势严重，用砭法刺络放血。
一方中有薄荷一钱，无人参。
另一方
治疗大头天行病（大头瘟），这是因为湿气位于高处的头部，不要用降气药。
羌活 酒芩（酒炒黄芩） 酒蒸大黄 水煎服。
又一方
治疗大头瘟疫如神效。
贯众（三钱） 葛根（三钱） 甘草（一钱五分） 白僵蚕（一钱） 加黑豆，水煎服。
人中黄，解除疫毒效果最好，是用甘草制造的，方法见本草部分。
《灵枢》说：面部与身形是相通的。天气寒冷时，大地开裂，冰凌凝结，有时手足懈怠下垂，为什么面部却不需衣物保暖呢？
回答说：十二经脉，三百六十五络，它们的血气都上注于面部，并运行至空窍。其中精阳气，上行至目而成为视觉。其支气走向耳而成为听觉。宗气上出于鼻而成为嗅觉。浊气出于胃，流经唇舌而成为味觉。这些气的津液，都向上熏蒸于面部，而且皮肤又厚，肌肉坚实，所以即使大热或大寒，也不能伤害它。
李东垣说：饮食不节制则导致胃病，胃病则气短，精神减少而生大热，有时火热之气上炎，独攻于面部。因为阳明经多气多血，又兼挟风热上行，诸阳经皆会聚于头面，所以导致面部发热如同醉酒状。治疗应当先疏散风热，或者使用调胃承气汤，加黄连、犀角，疏泄通便两三次，彻底清除根本的热邪，疏散风热，再用升麻汤，加黄连为主方治疗。
手足六条阳经，都上行至头部，而只有阳明胃脉的分支在鼻翼交额中，进入上齿中，挟口环绕嘴唇，沿颊车穴，上行至耳前，经过客主人穴（上关穴），所以人的面部，属于阳明经所主。如果胃中有热，有郁火则面部发热，用升麻汤加黄连。胃中有寒，则面部发冷，宜先用附子理中汤温补中焦之气，再用升麻汤加附子为主方治疗。如果风热内盛而上攻，令人面目浮肿，或者面鼻呈紫色，或者出现风刺瘾疹，随症状治疗。
面色黄白，鼻部发冷，这是阳气极度虚弱，宜用大剂量人参、附子为主方治疗。面部疼痛属于火证，因为诸阳经汇聚于面部，而火属阳，心的华彩表现在面部，而心主君火。然而突然疼痛多由火实引起，久病多因血虚。因为胃主管正面，且肠胃如集市般汇聚食物，因饮食的热毒积聚在中焦，则发作于外部，所以导致疼痛。还有过度劳累和饥饿时疼痛的，这是中气不足所致。
Shengong San (Divine Merit Powder) treats severe epidemic toxins and conditions such as Da Tou Wen (Big Head Plague).
Huangqin (Scutellariae Radix, wine-fried), Huanglian (Coptidis Rhizoma, wine-fried, each 5 qian), Juhong (Citri Reticulatae Pericarpium Rubrum), Xuanshen (Scrophulariae Radix), Lianqiao (Forsythiae Fructus), Shuniuzi (Arctii Fructus), Banlangen (Isatidis Radix), Mapibo (Euphorbiae Humifusae Herba), Sheng Gancao (Glycyrrhizae Radix et Rhizoma Raw), Chaihu (Bupleuri Radix), Jiegeng (Platycodonis Radix), Jiangcan (Bombyx Batryticatus, fried, each 2 qian), Xin Shengma ( Cimicifugae Rhizoma, 0.7 qian), Renshen (Ginseng Radix et Rhizoma, 3 qian). Grind into fine powder, take with decoction. Alternatively, make into honey pills for sucking. Some formulas add Fangfeng (Saposhnikoviae Radix), Danggui (Angelicae Sinensis Radix), Chuanxiong (Ligustici Chuanxiong Rhizoma). If stool is hard, add Jiuwei Dahuang (Rhei Radix et Rhizoma, wine-roasted) to promote bowel movement; if swelling and heat are severe, use Bianfa (stone needle therapy) to prick and bleed.
One formula contains Bohe (Menthae Haplocalycis Herba, 1 qian) and no Renshen.
Another formula
Treats Da Tou Tianxing Bing (Big Head Epidemic Disease). This is because dampness is located at the high peak of the head; do not use descending herbs.
Qianghuo (Notopterygii Rhizoma et Radix), Jiu Qin (Scutellariae Radix, wine-fried), Jiu Zheng Dahuang (Rhei Radix et Rhizoma, wine-steamed). Decoct in water and take.
Another formula
Treats Da Tou Yi (Big Head Plague) with miraculous effect.
Guanzhong (Cyathulae Officinalis Rhizoma or Cibotii Rhizoma, 3 qian), Gegen (Puerariae Lobatae Radix, 3 qian), Gancao (Glycyrrhizae Radix et Rhizoma, 1.5 qian), Bai Jiangcan (Bombyx Batryticatus, 1 qian). Add Heidou (Sojae Semen Nigrum), decoct in water and take.
Ren Zhonghuang (Human Manure Yellow), which resolves epidemic toxins excellently, is manufactured using Gancao. The method is seen under Bencao (Materia Medica).
The *Ling Shu* states: The face is connected to the body shape. When heaven is cold, the earth cracks and ice forms; sometimes hands and feet become flaccid and drooping, yet why does the face not require clothing?
It is said: The twelve meridians and three hundred and sixty-five collaterals, their blood and qi all ascend to the face and flow into the orifices. Their refined yang qi ascends to the eyes to form vision. Its branch qi flows to the ears to form hearing. The Zong Qi (Gathering Qi) emerges from the nose to form smell. The turbid qi comes from the stomach, flows through the lips and tongue to form taste. The fluids of these qi all steam upwards onto the face, and since the skin is thick and the flesh firm, even extreme heat or cold cannot overcome it.
Li Dongyuan says: Irregular diet leads to Stomach disease; Stomach disease leads to shortness of breath, reduced spirit, and generation of great heat. Sometimes fire qi flares up, attacking only the face. Because the Yangming Meridian has abundant qi and blood, and is accompanied by wind-heat ascending, and all Yang meridians converge on the head and face, this causes the face to feel hot like drunkenness. Treatment should first disperse wind-heat, or use Tiao Wei Cheng Qi Tang (Regulate the Stomach Order the Downward Flow Decoction) added with Huanglian and Xijiao (Rhinocerotis Cornu), to purge two or three times, thoroughly eliminating the root heat and dispersing wind-heat. Then use Shengma Tang (Cimicifuga Decoction) added with Huanglian as the main prescription.
The six Yang meridities of the hands and feet all ascend to the head, but only the Yangming Stomach Meridian crosses at the nose to the forehead, enters the upper teeth, surrounds the lips along the cheeks, ascends before the ear, passes through Kerenren (Shangguan, GB 4), thus the human face belongs to the Yangming Meridian. If there is heat in the Stomach, or stagnant fire, the face becomes hot; use Shengma Tang added with Huanglian. If there is cold in the Stomach, the face feels cold; first use Fuzi Lizhong Tang (Aconite Regulate the Middle Decoction) to warm the middle qi, then use Shengma Tang added with Fuzi (Aconiti Lateralis Radix Praeparata) as the main prescription. If wind-heat is severe internally and attacks upward, causing facial and eye swelling, or purple coloration of the face and nose, or wind-thorns and urticaria, treat according to symptoms.
Yellowish or pale face with a cold nose indicates extreme deficiency of Yang qi; use large doses of Renshen and Fuzi as the main prescription. Facial pain is due to fire, as all Yang meridities converge on the face, and fire is Yang. The brilliance of the Heart manifests on the face, and the Heart governs Minister Fire. However, sudden pain is mostly due to excess fire, while chronic illness is often due to blood deficiency. Because the Stomach governs the front aspect of the face, and the intestines and stomach are like a market gathering food, if heat toxins from diet accumulate in the middle, they manifest externally, causing pain. There are also cases where pain occurs due to overexertion or hunger; this is due to insufficiency of Middle Qi.