治杨梅疮毒蔓延周身，或上至顶，或下至足，或深入骨髓，无论陈、新、轻、剧，服之皆有奇效。三四
日间疮痂即脱落。
净轻粉（二钱，炒至光色减去三分之二，研细，盖此药炒之则烈性少缓，若炒之过度，又恐无力，火候宜中，
用其大片即净轻粉。） 净红粉（一钱，研细，须多带紫黑片者用之，方有效验。） 露蜂房（如拳大者一个，
大者可用一半，小者可用两个，炮至半黑半黄色，研细，炮时须用物按之着锅。） 核桃（十个，去皮捣碎，炮
至半黑半黄色，研细，纸包数层，压去其油，盖油多即不好为丸用。）
上诸药用熟枣肉为丸，黄豆粒大，晒干，分三次服之。服时，须清晨空心开水送下，至午后方可饮食，
忌腥半月。服后，口含柳棍，有痰涎即吐出，愈多吐愈好。睡时将柳棍横含，两端各系一绳，两绳之端结于脑
后，防睡着掉落。又须将柳棍勤换，即将药服完仍须如此，必待不吐痰涎时，方可不含柳棍。其药日服一次，
若恶心太甚者，可间日一服。制此药时，须自经手，将轻粉、红粉称极准，其秤当以库秤为定法，轻粉须称准
后再炒。
此方，人多有疑其服之断生育者，非也。轻粉虽烈， 之则
烈性顿减，红粉虽性近轻粉而止用一钱，且分作三日服之，又有枣肉之甘缓以解毒，核桃仁多用至十枚，峻补
肾经以防患，配合得宜，服之自有益无害。
轻粉系水银同矾石升炼而成，红粉亦系水银同矾石、硝石诸药升炼而成，其质本重坠，故能深入，其成于
升炼，故能飞扬。是以内浃骨髓，中通脏腑，外达皮肤，善控周身之毒涎，借径于阳明经络，自齿龈（上龈属
足阳明下龈属手阳明）而出也。蜂房，能引人身之毒涎透退场门齿，且有以毒攻毒之妙用，为轻粉、红粉之佐使。
毒涎之出者愈多，即内毒之消者愈速矣。核桃仁润而多脂，性能补骨益髓可知。且又善解疥癣之毒，其能解他
疮之毒亦可知。加于此药之中，补正兼以逐邪，毒之深入骨髓者亦不难消除矣。至于丸以枣肉，取其甘缓之性，
能缓二粉之猛悍，又能补助肠胃使不为毒药所伤也。
服药之后，其牙龈必肿，间有烂者，因毒涎皆从此出故也。然内毒既清，外证不治自愈，或用甘草、蓬砂、
金银花熬水漱之亦可。
蜂房有三种∶有黄色大蜂其房上下恒作数层，其毒甚大不宜用。曾见有以之煎水漱牙疼者，其牙龈遂皆溃
烂脱牙十余枚。有黄色小蜂其房甚小，房孔仅如绿豆，虽无大毒而力微，又不堪用。惟其蜂黄而兼红，大近寸
许，恒在人家屋中垒房，俗呼为马蜂，其房入药最宜。然其房在树上者甚少，若无在树上之露蜂房，在屋中者
亦可用，特稍宜加重耳。
马姓，年四十余，先染淋毒，后变为梅毒，求为延医。其毒周身不现形迹，惟觉脑际沉昏颇甚，心中时或
烦躁，骨节多有疼痛之处，所甚异者，其眉棱眼稍及手指之节多生软骨，西人亦谓系梅毒所凝结也。愚对此证，
不敢谓其必治愈，犹幸身体不甚羸弱，遂将洗髓丹一剂俾分四次服完。歇息旬日，再服一剂，将其
分量减三分之一。歇息旬日，又服一剂，较二次所服之分量又减三分之一，皆四日服完，其病递次消除。凡软
骨将消者，必先发起，然后徐徐消肿，化为无有。共计四浃辰，诸病皆愈。
又治一郝姓小孩，因食乳传染，咽喉溃烂，至不能进食，肛门亦甚溃烂，其肠胃之溃烂可知。其父来院细
言其病状，问还有救否？答曰∶“果信用余方，仍能救。”遂与以洗髓丹六粒，俾研细水调服三次，全愈。
又∶奉天一幼童，有遗传性梅毒，年六岁不能行，遍身起疮若小疖，愈而复发，在大连东人医院住近一年
不愈。后来院求治，其身体羸弱，饮食甚少，先用药理其脾胃，俾能饮食。渐加以解毒之药，若金银花、连翘、
天花粉诸品，身体渐壮，疮所发者亦渐少，然毒之根蒂仍未除也。遂将洗髓丹五分许研细（将制成丸药复研末
者因孺子不能服丸药也），开水调服，三日服一次，仍每日服汤药一剂。后将洗髓丹服至十次，疮已不发。继
又服汤药月余，兼用滋阴补肾之品，每剂中有核桃仁三个，取其能健骨也（食酸 齿者嚼核桃仁立愈是能健骨
之明征），从此遂能步履行动如常童矣。观此二案，则洗髓丹奇异之功效，诚可于解梅毒药中首屈一指。且凡
解梅毒药，无论或注射、或服药，愈后又恒肢体作疼，以其能清血中之毒，不能清骨中之毒，是以愈后其骨节
犹疼也。因其骨中犹含有毒性，恒迟至日久而复发，或迟至十余年而复发者，若再投以此丹，则骨疼立愈，且
以后永不反复，此又愚屡经试验而确知其然者也。
治疗杨梅疮毒蔓延全身，或者上至头顶，或者下至足部，或者深入骨髓，无论是陈旧性还是新发性，病情轻或重，服用此药都有奇效。三到四天内，疮痂就会脱落。
净轻粉（二钱，炒至发出光亮色泽后减去三分之二重量，研成细末；盖因药物经炒制则烈性稍缓，若炒制过度，又恐药效不足，火候应适中，使用其大片状即为净轻粉。）净红粉（一钱，研成细末，必须多带有紫黑色片状者使用，才有效验。）露蜂房（如拳头大小者一个，大的可用半个，小的可用两个，炮制至半黑半黄色，研成细末，炮制时须用物体按压使其紧贴锅底。）核桃（十个，去皮捣碎，炮制至半黑半黄色，研成细末，用纸包裹数层，压榨去除其油脂，盖因油多即不适合做丸药使用。）
以上诸药利用熟枣肉作为粘合剂制成丸药，大小如黄豆粒，晒干，分三次服用。服药时，须在清晨空腹时用开水送服，直到中午后方可进食，忌食腥膻食物半个月。服药后，口中含柳棍，有痰涎即吐出，吐得越多越好。睡觉时将柳棍横含在口中，两端各系一根绳子，两绳的末端结于脑后，防止睡着时掉落。又须勤换柳棍，即使将药服完仍须如此，必须等到不再吐出痰涎时，方可不含柳棍。该药每日服用一次，如果恶心太严重，可隔日服用一次。制作此药时，必须亲自经手，将轻粉、红粉称量极其准确，秤法应以库秤为标准，轻粉须称准后再进行炒制。
此方，许多人怀疑服用后会断绝生育能力，并非如此。轻粉虽然猛烈，但经过炒制后烈性顿减，红粉虽然药性接近轻粉但只用一钱，且分作三日服用，又有枣肉的甘缓之性以解毒，核桃仁多用至十枚，峻补肾经以防患，配合得当，服用自然有益无害。
轻粉是由水银同矾石升炼而成，红粉也是由水银同矾石、硝石等药升炼而成，其质地本沉重坠降，故能深入体内；其成于升炼工艺，故能飞扬上行。因此内达骨髓，中通脏腑，外达皮肤，善于控制周身之毒涎，借道于阳明经络，自齿龈（上龈属足阳明胃经，下龈属手阳明大肠经）而出。蜂房，能引人身之毒涎透退至场门齿处，且有以毒攻毒的妙用，作为轻粉、红粉的佐使药。毒涎排出的越多，即内部毒素消除得越快。核桃仁润泽且多脂，性能补骨益髓可知。而且又善于解疥癣之毒，其能解其他疮毒也可知。加入此药之中，补正气兼以驱逐邪气，深入骨髓的毒素也不难消除了。至于用枣肉做丸，取其甘缓之性，能缓和二粉（轻粉、红粉）的猛悍，又能补助肠胃使其不被毒药所伤。
服药之后，牙龈必然肿胀，间或有溃烂者，因为毒涎皆从此处排出所致。然而内部毒素既已清除，外部症状不治自愈，或用甘草、蓬砂、金银花熬水漱口也可以。
蜂房有三种：有黄色大蜂，其巢上下常作数层，其毒甚大不宜使用。曾见有人用它煎水漱口治牙疼，结果牙龈遂皆溃烂脱落牙齿十余枚。有黄色小蜂，其巢很小，巢孔仅如绿豆，虽无大毒但力微弱，又不堪使用。只有那种蜂黄而兼红，大小近一寸许，常在人家屋中垒巢，俗呼为马蜂，其巢入药最适宜。然而其在树上的很少，若无在树上的露蜂房，在屋中的也可以使用，只是稍微宜加重剂量罢了。
马姓患者，年四十多岁，先染淋毒，后变为梅毒，求我为他延医诊治。其毒在周身不现形迹，只觉头脑沉昏颇甚，心中时或烦躁，骨节多有疼痛之处，特别奇怪的是，其眉棱眼稍及手指之节多生软骨，西人也认为系梅毒所凝结。我对这种病症，不敢说一定能治愈，幸好身体不甚羸弱，于是将洗髓丹一剂让他分四次服完。休息十天，再服一剂，将其分量减少三分之一。休息十天，又服一剂，较第二次所服的分量又减少三分之一，都在四日内服完，其病依次消除。凡软骨即将消散者，必先发起红肿，然后徐徐消肿，化为乌有。共计四个十日周期，诸病皆愈。
又治疗一郝姓小孩，因吃奶传染，咽喉溃烂，至不能进食，肛门亦甚溃烂，其肠胃之溃烂可想而知。其父来院详细诉说其病状，问还有救否？我回答：“果真信任我的方子，仍能救活。”于是给予洗髓丹六粒，让他研细用水调服三次，全愈。
又：奉天一幼童，有遗传性梅毒，年六岁不能行走，遍身起疮若小疖，愈而复发，在大连东人医院住近一年不愈。后来来院求治，其身体羸弱，饮食甚少，先用药物调理其脾胃，使其能进食。逐渐加上解毒之药，如金银花、连翘、天花粉等品，身体渐壮，疮所发者亦渐少，然而毒之根蒂仍未除也。于是将洗髓丹五分许研细（将制成丸药复研末者，因孺子不能服丸药也），开水调服，三日服一次，仍每日服汤药一剂。后将洗髓丹服至十次，疮已不发。继又服汤药月余，兼用滋阴补肾之品，每剂中有核桃仁三个，取其能健骨也（食酸物导致牙齿酸痛者嚼核桃仁立愈是能健骨之明征），从此遂能步履行动如常童矣。观此二案，则洗髓丹奇异之功效，诚可于解梅毒药中首屈一指。且凡解梅毒药，无论或注射、或服药，痊愈后又恒肢体作疼，以其能清血中之毒，不能清骨中之毒，是以痊愈后其骨节犹疼也。因其骨中犹含有毒性，常迟至日久而复发，或迟至十余年而复发者，若再投以此丹，则骨疼立愈，且以后永不反复，这又是我也屡次试验而确知其然者也。
Treatment for yaws (yangmei chuang) toxin spreading throughout the body, or ascending to the vertex, or descending to the feet, or penetrating deeply into the bone marrow. Regardless of whether it is chronic or acute, mild or severe, administration of this prescription yields miraculous effects. The scabs and sores will fall off within three to four days.
Jing Qingfen (Calomel, 2 qian, stir-fried until a glossy color appears, then reduced by two-thirds of its weight, and ground into fine powder; note that stir-frying moderates the intense nature of this drug, but over-frying may render it ineffective; the heat control should be moderate, using the large flakes constitutes Jing Qingfen.) Jing Hongfen (Red Powder/Red Mercuric Oxide, 1 qian, ground into fine powder; it must contain many purple-black flakes to be effective.) Lu Fengfang (Honeycomb from wild bees exposed to dew, one piece the size of a fist; for larger pieces, use half; for smaller pieces, use two. Stir-fry until half black and half yellow, then grind into fine powder. During stir-frying, press the material firmly against the pot bottom with an object.) Walnut (10 pieces, peeled and crushed, stir-fried until half black and half yellow, ground into fine powder, wrapped in several layers of paper, and pressed to remove the oil; excessive oil makes it unsuitable for pill formation.)
The above herbs are combined with cooked jujube flesh to form pills, sized like soybeans, dried in the sun, and divided into three doses. Administration requires taking the pills on an empty stomach in the early morning with warm water; food intake should be delayed until noon. Avoid greasy/fishy foods for half a month. After ingestion, hold a willow stick in the mouth; expectorate phlegm and saliva immediately. The more expectorated, the better. When sleeping, place the willow stick horizontally in the mouth, tying a string to each end, and knotting the other ends behind the head to prevent dropping during sleep. Replace the willow stick frequently; continue this practice even after finishing the medication, only stopping when no more phlegm/saliva is produced. Take the medicine once daily; if nausea is severe, take it every other day. Preparation must be done personally, weighing Qingfen and Hongfen with extreme precision using standard government scales (Ku Cheng). Qingfen must be weighed accurately before stir-frying.
Many doubt that this prescription causes sterility, which is incorrect. Although Qingfen is potent, its intensity is greatly reduced by stir-frying. Hongfen has a similar nature to Qingfen but is used in small amounts (1 qian) and divided over three days. The sweet and緩 (soothing) nature of jujube flesh detoxifies, while ten walnuts strongly tonify the Kidney channel to prevent adverse effects. With proper combination, administration is beneficial and harmless.
Qingfen is produced by sublimating mercury with alum stones; Hongfen is also produced by sublimating mercury with alum stones, saltpeter, and other drugs. Their heavy nature allows them to penetrate deeply; their production via sublimation allows them to ascend and disperse. Thus, they reach the bone marrow internally, connect with the Zang-Fu organs centrally, and extend to the skin externally. They effectively control toxins and fluids throughout the body, utilizing the Yangming meridians as a pathway, exiting through the gums (upper gums belong to Foot-Yangming Stomach Meridian, lower gums belong to Hand-Yangming Large Intestine Meridian). Honeycomb guides the body's toxic fluids to exit through the gums and possesses the subtle function of "using poison to treat poison," serving as an assistant and guide (Zuo Shi) to Qingfen and Hongfen. The more toxic fluid expelled, the faster internal toxins are eliminated. Walnuts are moist and oily, indicating their ability to tonify bones and benefit marrow. They also resolve toxins from scabies and tinea, implying efficacy against other sore toxins. Added to this prescription, they tonify healthy Qi while expelling pathogens, making it easy to eliminate toxins deep in the bone marrow. Jujube flesh is used for pills due to its sweet and soothing nature, which moderates the harshness of the two powders and protects the spleen and stomach from toxic damage.
After administration, gum swelling and occasional ulceration are expected, as toxic fluids exit through this area. Once internal toxins are cleared, external symptoms heal spontaneously. Alternatively, gargle with decoctions of Licorice Root (Gancao), Borax (Pengsha), and Honeysuckle Flower (Jinyinhua).
There are three types of honeycomb: Yellow large-bee combs are multi-layered and highly toxic, unsuitable for use. I have seen cases where decoction was used for toothache, resulting in gum ulceration and loss of over ten teeth. Yellow small-bee combs are very small with pores the size of mung beans; although not highly toxic, their potency is weak and unsuitable. The ideal type comes from bees that are yellow and reddish, about one cun in size, often building nests in houses, commonly called horse bees (Ma Feng). Their combs are most suitable for medicine. Combs found on trees are rare; if unavailable, house combs can be used, though the dosage should be slightly increased.
Case 1: Mr. Ma, over forty years old, initially contracted gonorrhea toxin, which later transformed into syphilis. He sought medical treatment. The toxin showed no visible signs on the body, but he experienced severe heaviness and dizziness in the head, occasional irritability, and pain in many joints. Notably, cartilage-like growths appeared around his eyebrows, eyes, and finger joints; Western medicine also attributes this to syphilitic condensation. I dared not guarantee a cure, but fortunately, his constitution was not too emaciated. I prescribed one dose of Xisui Dan to be taken in four divided doses. After resting for ten days, he took another dose, reducing the amount by one-third. After another ten days, he took a third dose, reducing the amount by another one-third compared to the second, completing each dose over four days. The illness gradually resolved. Cartilage lesions first inflamed, then slowly subsided and disappeared. Within four cycles of ten days, all diseases were cured.
Case 2: A child surnamed Hao contracted the disease through breastfeeding. Throat ulcers prevented eating, and anal ulcers were severe, implying gastrointestinal ulceration. His father asked if there was hope. I replied, "If you trust my prescription, he can still be saved." I gave him six pills of Xisui Dan, ground finely and mixed with water, administered three times, resulting in complete recovery.
Case 3: A young child in Fengtian had hereditary syphilis. At age six, he could not walk, and his body was covered in boils that healed and recurred. He stayed in a Japanese hospital in Dalian for nearly a year without improvement. Upon seeking treatment at our clinic, he was emaciated and ate little. First, we regulated his Spleen and Stomach to improve appetite. Gradually, we added detoxifying herbs such as Honeysuckle Flower (Jinyinhua), Forsythia Fruit (Lianqiao), and Trichosanthes Root (Tianhuafen). His physique strengthened, and sores decreased, but the root of the toxin remained. We then administered approximately 5 fen of Xisui Dan, ground into powder (since the child could not swallow pills), mixed with warm water, taken once every three days, alongside a daily herbal decoction. After ten doses of Xisui Dan, sores ceased appearing. He continued the decoction for over a month, combined with Yin-nourishing and Kidney-tonifying herbs, including three walnuts per dose to strengthen bones (the fact that chewing walnuts instantly relieves toothache caused by sour foods is clear evidence of this property). Consequently, he regained normal walking ability. These two cases demonstrate that Xisui Dan’s miraculous efficacy ranks first among syphilis treatments. Furthermore, conventional syphilis treatments (injections or oral meds) often leave patients with limb pain post-cure because they clear blood toxins but fail to clear bone toxins. Residual bone toxicity often leads to recurrence after long periods or even decades. Re-administering this pill cures bone pain immediately and prevents future recurrence, a fact confirmed by my repeated trials.