漏芦 升麻 大黄 蓝叶 黄芩 玄参等分 芒硝（甚者加至二钱）
疫疠积热，时生疙瘩结毒，俗称流注，面肿咽塞者，此方主之。
经曰∶营气不从，逆于肉理，乃生毒痈；又曰∶热胜则肿，故疫疠之余热，解之未尽，
逆留于分肉之间，则作上件诸证。药之为性，辛能解散，苦能胜热，漏芦、升麻、蓝叶，辛
而且苦，故足以解结热；咸能软坚，苦能泻实，大黄味苦，芒硝味咸，故足以软坚而泻实；
玄参苦而润，黄芩苦而枯，润者去血中之热，而枯者去气中之热尔，况与漏芦、升麻走散之
药同用之，则又无所不至矣。
大黄（酒浸） 牡蛎（炙） 僵蚕（等分）
疫毒内郁，时成疙瘩者，此方主之。
《内经》曰∶陷脉为 ，留连肉腠。谓阳毒乘脉之虚而陷入之，便壅结而为 核，留连
于肉腠之间，正此疫毒疙瘩之谓也。苦能下热，故用大黄；咸能软坚，故用僵蚕、牡蛎。
凡觉天行时气，恐其相染，须日饮雄黄酒一卮，仍以雄黄豆许用绵裹之，塞鼻一窍，男
左女右用之。或用大蒜塞鼻，或用阿魏塞鼻皆良。
雄黄气悍，能辟恶邪；大蒜、阿魏，气之至臭者，臭胜则诸秽皆不足以加之矣。但蒜大
热，阿魏透脑，虚人难用，不若雄黄便于事尔。
叙曰∶大头瘟，前古未之论也，东垣始论之。
今上壬午，北方病此者甚众，死者不啻数万人。昆居南土，未尝见其证。乡人自北来者
，皆言患者头大如斗，跻头而还自若也。今考三方，观其大略。
漏芦、升麻、大黄、蓝叶、黄芩、玄参各等分，芒硝（病情严重者加至二钱）。
治疗疫疠之气积聚的热毒，时常产生疙瘩结聚的毒疮，俗称流注，导致面部肿胀、咽喉堵塞的症状，此方主治。
《内经》说：营气运行不畅，逆乱于肌肉纹理之间，就会生成毒痈；又说：热邪亢盛则会导致肿胀。所以疫病之后的余热，如果未能彻底清除，逆留于分肉（肌肉间隙）之间，就会产生上述各种症状。药物的性质是：辛味能解散邪气，苦味能胜退热邪，漏芦、升麻、蓝叶，既辛又苦，所以足以解除结聚的热邪；咸味能软化坚积，苦味能泻下实邪，大黄味苦，芒硝味咸，所以足以软化坚积并泻下实邪；玄参味苦而滋润，黄芩味苦而燥枯，滋润的药物能去除血中的热邪，而燥枯的药物能去除气中的热邪，况且与具有走散作用的漏芦、升麻同用，药力就能无所不到。
《内经》说：邪气陷入经脉成为“瘰疬”，停留连缀于肌肉腠理之间。这是指阳毒趁着经脉的虚弱而陷入其中，便壅塞结聚而形成核状物，停留连缀在肌肉腠理之间，正是所说的疫毒疙瘩。苦味能下行清热，所以使用大黄；咸味能软化坚积，所以使用僵蚕和牡蛎。
凡是感觉遇到流行性时气（传染病），担心被传染，应当每天饮用雄黄酒一杯，另外取黄豆大小的雄黄，用棉布包裹，塞入一侧鼻孔，男性塞左鼻，女性塞右鼻。或者使用大蒜塞鼻，或者使用阿魏塞鼻，效果都很好。
雄黄药性猛烈，能辟除恶邪；大蒜和阿魏，气味极其臭秽，以臭胜则各种秽浊之气都不足以侵犯人体了。但是大蒜大热，阿魏气味透脑，体虚的人难以使用，不如雄黄便于应用。
今年壬午年，北方患此病的人非常多，死亡人数不止几万人。我居住在南方，未曾见过这种病症。从北方来的人都说，患者头部肿大如斗，走路时头依然保持平衡自如。现在考证这三个方子，观察其大概情况。
Rhizoma Euphorbiae Humifusae (Loulu), Rhizoma Cimicifugae (Shengma), Radix et Rhizoma Rhei (Dahuang), Folium Isatidis (Lanye), Radix Scutellariae (Huangqin), Radix Scrophulariae (Xuanshen) in equal parts; Natrii Sulfas (Mangxiao) (increase to 2 qian for severe cases).
This formula is indicated for epidemic pestilence with accumulated heat, manifesting as nodules and toxic swellings, commonly known as Liuzhu (flowing abscesses), characterized by facial swelling and pharyngeal obstruction.
The *Neijing* states: "When Ying Qi (Nutritive Qi) does not flow smoothly and reverses into the muscle tissue, toxic carbuncles arise"; it also states: "Excessive heat leads to swelling." Therefore, residual heat from an epidemic, if not fully resolved, may reverse and remain between the muscles (Fenrou), causing the aforementioned symptoms. The nature of herbs is such that Pungent flavors can disperse, and Bitter flavors can overcome heat. Loulu, Shengma, and Lanye are both pungent and bitter, thus sufficient to resolve knotting heat; Salty flavors can soften hardness, and Bitter flavors can purge excess. Dahuang is bitter, and Mangxiao is salty, thus sufficient to soften hardness and purge excess; Xuanshen is bitter and moistening, while Huangqin is bitter and drying. Moistening herbs remove heat from the blood, while drying herbs remove heat from the Qi. Moreover, when used together with dispersing herbs like Loulu and Shengma, their therapeutic effects reach everywhere.
Radix et Rhizoma Rhei (Dahuang) (soaked in wine), Concha Ostreae (Muli) (calcined), Bombyx Batryticatus (Jiangcan) in equal parts.
This formula is indicated for internal stagnation of epidemic toxins, manifesting as nodules.
The *Neijing* states: "When pathogens sink into the vessels, they become scrofula (Luo Li), lingering in the muscle interstices." This refers to Yang toxins taking advantage of vessel deficiency to sink in, causing congestion and knotting into nodular masses, lingering in the muscle interstices, which precisely describes epidemic toxin nodules. Bitter flavors can descend and clear heat, hence Dahuang is used; Salty flavors can soften hardness, hence Jiangcan and Muli are used.
Whenever one feels exposed to seasonal epidemic Qi and fears infection, one should drink a cup of Xionghuang Wine daily. Additionally, take a piece of Xionghuang (Asinum Corneum / Realgar) the size of a soybean, wrap it in cotton, and insert it into one nostril (left for males, right for females). Alternatively, using Garlic or Asafetida (Awei) inserted into the nose is also effective.
Xionghuang has a potent aroma capable of repelling evil pathogens; Garlic and Awei have extremely foul odors; overpowering foulness prevents all turbid evils from invading. However, Garlic is excessively hot, and Awei's odor penetrates the brain, making them difficult to use for deficient individuals, whereas Xionghuang is more convenient for practical application.
Preface: Da Tou Wen (Big Head Plague) was not discussed in ancient texts; Li Dongyuan was the first to discuss it.
In the Renwu year of this reign, many in the North suffered from this disease, with deaths exceeding tens of thousands. I reside in the South and have never witnessed these symptoms. Those coming from the North report that patients' heads swelled as large as a bushel basket, yet they walked with their heads remaining steady and balanced. Here, I examine these three formulas to observe their general principles.