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《灵枢·五禁篇》曰∶热病脉静，汗已出，脉盛躁，是一逆也；病泄，脉洪大，是二逆也；
着痹不移， 肉破，身热，脉偏绝，是三道也；淫而夺形，身热，色夭然白，及后下血 ，血
笃重，是四逆也；寒热夺形，脉坚搏，是谓五逆也。犯五逆者为不治。
玉版篇曰∶腹胀，身热，脉大，是一逆也；腹鸣而满，四肢清，泄，其脉大，是二逆也；衄
而不止，脉大，是三逆也；咳且溲血脱形，其脉小劲，是四逆也；咳而脱形，身热，脉小以疾，
是谓五逆。如是者，不过十五日而死矣。其腹大胀，四末清，脱形，泄甚，是一逆也；腹胀便血，
其脉大，时绝，是二逆也；咳，溲血，形肉脱，脉搏，是三逆也；呕血，胸满引背，脉小而疾，
是四逆也；咳呕腹胀，且飧泄，其脉绝，是五逆也。如是者，不及一时而死矣。工不察此者而刺
之，是谓逆治。
（其经病其脉绝者死）
冲阳绝，死不治。（足阳明胃经，脉在足大指后陷中，有动脉应指是也。）尺泽绝，死不治。
（手太阴肺经，脉在手臂曲纹陷中，有动脉应指是也。）天府绝，死不治。（手太阴肺经，脉在
手臂内肩 下，有动脉应指是也。）太冲绝，死不治。（足厥阴肝经，脉在足内大指后二寸，动
脉应指是。）神门绝，死不治。（手少阴心经，脉在手掌内侧，有动脉应指是也。）太溪绝，死
不治。（足少阴肾经，脉在足内踝骨下，有动脉应指者是也。）
《灵枢·五禁篇》说：热病脉象安静，汗出之后，脉象反而盛大躁动，这是第一种逆证；患泄泻病，脉象洪大，这是第二种逆证；着痹（湿邪偏盛的痹证）疼痛固定不移，肌肉溃破，身体发热，脉象一侧断绝，这是第三种逆证；因淫欲过度导致形体消瘦，身体发热，面色枯槁苍白，随后出现便血，且血量多病情沉重，这是第四种逆证；寒热交替导致形体消瘦，脉象坚硬搏指，这叫做第五种逆证。犯有这五种逆证的病人属于不治之症。
《玉版篇》说：腹部胀满，身体发热，脉象大，这是第一种逆证；肠鸣音亢进且腹部胀满，四肢厥冷，泄泻，脉象大，这是第二种逆证；鼻出血不止，脉象大，这是第三种逆证；咳嗽且小便带血，形体脱失（极度消瘦），脉象细小而强劲，这是第四种逆证；咳嗽且形体脱失，身体发热，脉象细小且快速，这叫做第五种逆证。像这样的病人，不超过十五天就会死亡。如果腹部高度胀满，四肢清冷，形体脱失，泄泻严重，这是第一种逆证；腹部胀满并大便带血，脉象大且时有断绝，这是第二种逆证；咳嗽、小便带血，肌肉消脱，脉搏坚劲有力，这是第三种逆证；呕血，胸部胀满牵引背部疼痛，脉象小而快，这是第四种逆证；咳嗽、呕吐、腹部胀满，并且伴有完谷不化的泄泻，脉象断绝，这是第五种逆证。像这样的病人，不到一个时辰就会死亡。医生如果不明察这些情况而进行针刺治疗，这叫做逆治（错误的治法）。
（如果是经脉之气断绝的，病人会死亡）
冲阳穴脉气断绝，病人死亡且无法治愈。（足阳明胃经，脉位于足大趾后方凹陷处，有动脉跳动应指。）尺泽穴脉气断绝，病人死亡且无法治愈。（手太阴肺经，脉位于手臂弯曲纹路处的凹陷中，有动脉跳动应指。）天府穴脉气断绝，病人死亡且无法治愈。（手太阴肺经，脉位于手臂内侧肩下处，有动脉跳动应指。）太冲穴脉气断绝，病人死亡且无法治愈。（足厥阴肝经，脉位于足内踝后二寸处，有动脉跳动应指。）神门穴脉气断绝，病人死亡且无法治愈。（手少阴心经，脉位于手掌内侧，有动脉跳动应指。）太溪穴脉气断绝，病人死亡且无法治愈。（足少阴肾经，脉位于足内踝骨下方，有动脉跳动应指。）
The *Ling Shu: Wu Jin Chapter* states: In febrile diseases, if the pulse is quiet, but after sweating it becomes rapid and restless, this is the first adverse sign; if a patient suffers from diarrhea and the pulse is flooding (Hong), this is the second adverse sign; in fixed Bi syndrome (Bi syndrome dominated by dampness) where pain does not shift, muscles are ulcerated, the body is hot, and the pulse is absent on one side, this is the third adverse sign; due to excessive sexual indulgence leading to emaciation, with body heat, sallow and pale complexion, followed by hematochezia that is severe and heavy, this is the fourth adverse sign; alternating chills and fever leading to emaciation, with a firm and bounding pulse, this is called the fifth adverse sign. Those who present with these five adverse signs are incurable.
The *Yu Ban Chapter* states: Abdominal distension, body heat, and a large pulse constitute the first adverse sign; borborygmus with fullness, cold extremities, diarrhea, and a large pulse constitute the second adverse sign; persistent epistaxis with a large pulse constitutes the third adverse sign; coughing accompanied by hematuria and emaciation, with a fine and forceful pulse, constitutes the fourth adverse sign; coughing with emaciation, body heat, and a fine and rapid pulse constitutes the fifth adverse sign. Patients presenting thus will die within fifteen days. If there is severe abdominal distension, cold extremities, emaciation, and profuse diarrhea, this is the first adverse sign; abdominal distension with bloody stools, a large pulse that intermittently disappears, is the second adverse sign; coughing, hematuria, loss of muscle mass, and a surging pulse constitute the third adverse sign; hematemesis, chest fullness radiating to the back, and a small and rapid pulse constitute the fourth adverse sign; coughing, vomiting, abdominal distension, along with undigested stool in diarrhea (Sun Xie), and an absent pulse constitute the fifth adverse sign. Patients presenting thus will die in less than one shi (two hours). If physicians fail to observe these conditions and proceed with acupuncture, it is termed "adverse treatment" (incorrect therapy).
(If the Qi of the meridians is exhausted, death ensues.)
Exhaustion of the Chongyang pulse leads to death and is incurable. (Foot-Yangming Stomach Meridian: The pulse is located in the depression behind the big toe, where arterial pulsation is felt.) Exhaustion of the Chi Ze pulse leads to death and is incurable. (Hand-Taiyin Lung Meridian: The pulse is located in the depression at the crease of the arm, where arterial pulsation is felt.) Exhaustion of the Tian Fu pulse leads to death and is incurable. (Hand-Taiyin Lung Meridian: The pulse is located below the shoulder on the medial aspect of the arm, where arterial pulsation is felt.) Exhaustion of the Tai Chong pulse leads to death and is incurable. (Foot-Jueyin Liver Meridian: The pulse is located two cun posterior to the big toe, where arterial pulsation is felt.) Exhaustion of the Shen Men pulse leads to death and is incurable. (Hand-Shaoyin Heart Meridian: The pulse is located on the medial aspect of the palm, where arterial pulsation is felt.) Exhaustion of the Tai Xi pulse leads to death and is incurable. (Foot-Shaoyin Kidney Meridian: The pulse is located below the medial malleolus, where arterial pulsation is felt.)