一、痘当靥之时，色转苍羸，成紫葡萄色者，一二日，决从口鼻四边靥起，腹中收至两腿，然额上和
脚一齐收靥，落皮而愈，此乃吉证也，不必惊疑下药。
一、痘当靥之时，遍身臭烂，如拼搭不可近，目中无神者，决死。
一、痘当靥之时，遍身发痒，抓搭无脓者，皮卷如豆壳干者，决死。
一、痘当靥之时，寒战，手足颤掉，切牙噤口，即死。
一、痘当靥之时，目闭无神，腹胀，足冷过膝者，决死。
一、痘当靥之时，声哑气急，痰响，小便少，大便频者，决死。
一、痘当靥之时，痘瘢雪白，全无血色，过后亦死，急用消毒
散二帖，后用助气血药以养脾胃，或可得也，宜预先治之。
方
败草散 治痘疮抓搔成脓，血淋漓。
用盖房多年烂草，或盖墙烂草亦可，其草经霜露，感天地阴阳之气，善解疮毒，其功不能尽述，取
草不拘多少，晒干，或焙干，为末，干贴疮上，若浑身疮破，脓水不绝，粘贴衣裳，难以坐卧，
可用二三升摊于席上，令儿坐卧，其效如神，仍服木香散，加丁香、官桂同煎服。
硝胆膏
硝胆膏医口不收，疮瘢臭烂血脓流，宜研猪胆芒硝细末，患处涂之病自瘳。
猪胆汁、芒硝二味研匀，如膏，涂之。
脱甲散 治疮甲不落，不能靥者。
雄黄 蝉蜕皮（去土） 人顶骨（烧灰，各一钱）
上为细末，每服三分，米汤下。
雄黄散 治小儿牙断，生疳蚀疮。
雄黄（一钱） 铜绿（二钱）
二味共研极细末，量儿大小，干掺上。
绵茧散 治痘疮，身体肢节上有疳蚀疮，脓水不绝。
空蚕茧（须是出蚕蛾了者）
一味不拘多少，用生白矾研细入内，茧内令满，以炭火烧，令白矾汁干尽，取出研极细，每用干贴疮口上。
猪尾膏
龙脑（半字许，研细，旋滴猪心血为丸，辰砂为衣，紫草汤化下）
一、痘疮在结痂脱落的时候，如果颜色转为苍老瘦弱，呈现紫葡萄色，通常在一两天内，会从口鼻周围开始结痂，腹部逐渐收口直至双腿。然而额头和脚部同时结痂，脱皮后痊愈，这是吉利的证候，不必惊慌怀疑而使用下药。
二、痘疮在结痂脱落的时候，全身溃烂发臭，如同拼凑粘连般不可靠近，眼睛没有神采的，必定死亡。
三、痘疮在结痂脱落的时候，全身发痒，抓挠处没有脓液，皮肤卷曲像豆壳一样干枯的，必定死亡。
四、痘疮在结痂脱落的时候，出现寒战，手足颤抖，咬牙紧闭口的，立即死亡。
五、痘疮在结痂脱落的时候，眼睛闭合无神，腹部胀满，双脚冰冷超过膝盖的，必定死亡。
六、痘疮在结痂脱落的时候，声音嘶哑气短急促，痰鸣有声，小便量少，大便频繁的，必定死亡。
七、痘疮在结痂脱落的时候，痘痕雪白，完全没有血色，过后也会死亡，急需使用消毒散两帖，之后服用补益气血的药物以滋养脾胃，或许可以得救，应当预先治疗。
方剂：
败草散 治疗痘疮因抓挠而成脓，血液淋漓。
使用盖房多年的烂草，或者盖墙的烂草也可以，这些草经过霜露，感应天地阴阳之气，善于解除疮毒，其功效无法详尽叙述。取草不拘多少，晒干或焙干，研为粉末，直接干贴于疮口上。如果全身疮破，脓水不绝，粘贴衣裳，难以坐卧，可用二三升铺在席子上，让孩子坐卧其上，效果如神。同时仍服用木香散，加入丁香、官桂共同煎服。
硝胆膏
硝胆膏治疗口唇不收，疮痕臭烂，血脓流出。适宜将猪胆汁和芒硝研成细末，涂抹患处，病自然痊愈。
猪胆汁、芒硝两味药研匀，制成膏状，涂抹患处。
脱甲散 治疗疮甲不脱落，不能结痂的。
雄黄 蝉蜕（去土） 人顶骨（烧成灰，各一钱）
以上研为细末，每次服用三分，用米汤送下。
雄黄散 治疗小儿牙齿断裂，生疳蚀疮。
雄黄（一钱） 铜绿（二钱）
两味药共研极细末，根据孩子的大小，适量干掺于患处。
绵茧散 治疗痘疮，身体肢节上有疳蚀疮，脓水不绝。
空蚕茧（必须是出蛾后的）
一味药不拘多少，用生白矾研细放入茧内，让茧装满，用炭火烧，使白矾汁干尽，取出研极细，每次用干贴于疮口上。
1. When the smallpox pustules are scabbing and falling off, if the color turns pale and emaciated, presenting a purple grape-like hue, within one or two days, the scabs will begin to form around the mouth and nose, receding from the abdomen down to both legs. However, if the forehead and feet scab simultaneously, healing after the skin peels off, this is an auspicious sign; there is no need for alarm or suspicion, nor should purgative medicines be administered.
2. When the smallpox pustules are scabbing and falling off, if the entire body is putrid and rotting, appearing as if stitched together and unapproachable due to foul odor, and the eyes lack spirit, death is certain.
3. When the smallpox pustules are scabbing and falling off, if the entire body itches, scratching yields no pus, and the skin curls up like dry bean pods, death is certain.
4. When the smallpox pustules are scabbing and falling off, if chills occur, limbs tremble, teeth are clenched, and the mouth is locked shut, death ensues immediately.
5. When the smallpox pustules are scabbing and falling off, if the eyes are closed without spirit, the abdomen is distended, and the feet are cold extending beyond the knees, death is certain.
6. When the smallpox pustules are scabbing and falling off, if the voice is hoarse with rapid breathing, phlegm rattles in the throat, urine output is scant, and bowel movements are frequent, death is certain.
7. When the smallpox pustules are scabbing and falling off, if the scar marks are snow-white with no blood color, death will follow later. Urgently administer two doses of Xiaodu San (Detoxification Powder), followed by herbs that tonify Qi and Blood to nourish the Spleen and Stomach; recovery may be possible. Treatment should be initiated in advance.
Formulas:
Baicao San (Rotten Grass Powder)
Indications: Smallpox sores becoming suppurative due to scratching, with dripping blood.
Usage: Use rotten grass from roofs used for many years, or rotten grass from walls. These grasses, having been exposed to frost and dew, absorb the Yin and Yang Qi of Heaven and Earth, and possess excellent properties for resolving sore toxins, though their full efficacy cannot be fully described. Take an unspecified amount of grass, dry it in the sun or bake it until dry, and grind it into powder. Apply the dry powder directly onto the sores. If the entire body is broken out with incessant pus, sticking to clothes and making sitting or lying difficult, spread two or three sheng [a traditional unit of volume] on the mat, allowing the child to sit or lie upon it. The effect is miraculous. Continue to administer Muxiang San (Costus Root Powder), decocted with Dingxiang (Clove) and Guigui (Cinnamon Twig).
Xiaodan Gao (Niter and Gallbladder Ointment)
Indications: Inability of the mouth/lips to close, foul-smelling scars with flowing bloody pus.
Usage: Grind Zhu Dan (Pig Gallbladder) and Mangxiao (Mirabilite) into fine powder. Apply to the affected area; the disease will heal spontaneously.
Preparation: Grind Pig Gallbladder and Mirabilite evenly to form an ointment, then apply.
Tuojia San (Falling Nail Powder)
Indications: Sores where the crusts/nails do not fall off, preventing proper scabbing.
Ingredients: Xionghuang (Realgar), Chantuitui (Cicada Slough, cleaned of soil), Rendingonggu (Human Vertex Bone, burnt to ash), each 1 qian.
Usage: Grind all ingredients into a fine powder. Take 3 fen per dose, washed down with rice water.
Xionghuang San (Realgar Powder)
Indications: Children with broken teeth, developing gan ulcers (nutritional deficiency sores) and erosive sores.
Ingredients: Xionghuang (Realgar) 1 qian, Tonglv (Malachite) 2 qian.
Usage: Grind both ingredients into an extremely fine powder. Apply dry powder appropriately according to the child's size.
Mianjian San (Silkworm Cocoon Powder)
Indications: Smallpox with gan erosive sores on the body and joints, with incessant pus.
Ingredients: Kong Canjian (Empty Silkworm Cocoon, specifically those from which moths have emerged).
Usage: Take an unspecified amount of empty cocoons. Fill them finely ground Sheng Baifan (Raw Alum). Burn over charcoal until the alum juice is completely dried. Remove, grind into an extremely fine powder, and apply dry powder to the sore openings.
Zhuwei Gao (Pig Tail Ointment)
Ingredients: Nao (Borneol, approx. half zi/grain, finely ground), mixed with fresh Pig Heart Blood to form pills, coated with Zhensha (Cinnabar).
Usage: Dissolve and administer with Zicao Tang (Arnebia Decoction).