论曰大肠虚冷之病，胸中喘，肠鸣，虚渴唇干，目急善惊，滑泄，骨节疼痛，不能久立
，盖大肠者，传导之官，变化出焉，寒邪客于其间，则令气虚弱，不能自固而成诸疾，诊其
脉右手气口以前阳虚者是也。
治大肠虚冷，腰痛羸瘦，附子汤方
附子（炮裂去皮脐一两半） 人参 干姜（炮裂） 赤芍药 桂（去粗皮） 甘草（炙
各一两）
上六味， 咀如麻豆，每服三钱匕，水一盏，入枣三枚，煎至六分，去滓食前温服。
治大肠虚冷，饮食减少，非时飧泄，茱萸丸方
吴茱萸（汤洗焙干炒） 诃黎勒皮 丁香 草豆蔻（去皮） 芎 防风（去叉各一分）
石硫黄
上七味，捣罗为末，炼蜜丸如梧桐子大，空心陈米汤下三十丸
治大肠虚冷，便利滑泄，不思饮食，肠鸣腹痛，朴附丸方
浓朴（去粗皮生姜汁炙一两） 附子（炮裂去皮脐半两） 甘草（炙一两） 干姜（炮
裂一两）
上四味，捣罗为末，酒煮面糊，丸如梧桐子大，每服五十丸，食前温米饮下。
治大肠气虚，又因伤风冒雨，大肠中下血，防风丸方
防风（去叉） 芎 （各一分） 黄 （锉） 术（各半两） 五味子 续断 陈橘皮
（汤浸去白各一分）
上八味，捣罗为末，炼蜜和丸如梧桐子大，空心盐米汤下三十丸。
治大肠虚寒，痢下白脓，肠内虚鸣相逐，黄连汤方
黄连（去须） 酸石榴皮（焙） 赤石脂（各三两） 白茯苓（去黑皮） 干姜（炮裂
各二两半） 桔梗（炒二
上六味， 咀如麻豆大，每服五钱匕，水一盏半，煎至八分，去滓温服，日三。
治大肠虚冷，痢下青白，肠中虚鸣相逐，黄连汤方
黄连（去须四两） 白茯苓（去黑皮） 芎 （各三两） 酸石榴皮（二两焙） 地榆
（五两） 伏龙肝（鸡
上六味，将前五味， 咀如麻豆大，每服五钱匕，水一盏半，煎至八分，下伏龙肝末
半钱匕，再煮一二沸，去滓温服，日再。
治大肠虚腹痛，不能久立，或腹中虚鸣，柴胡丸方
柴胡（去苗土） 枳壳（麸炒去瓤各一两半） 白术（三分） 白茯苓（去黑皮一两） 丹
参（去根炙） 黄
上六味，捣罗为末，炼蜜和丸如梧桐子大，空腹粥饮下三十丸，日三服。
治大肠虚，大建中汤方
干姜（炮裂一两半） 芍药 甘草（炙锉） 桂（去粗皮各一两）
上四味，粗捣筛，每服二钱匕，入枣三枚去核，饧一块，水一盏，煎至七分，去滓空腹
温服，日三。
论述说：大肠虚冷之病，表现为胸中气喘，肠鸣音亢进，因虚而渴、嘴唇干燥，眼睛拘急且容易受惊，大便滑脱不禁，骨节疼痛，不能久立。大概大肠是传导之官，负责变化糟粕，寒邪客居其中，就会导致气机虚弱，不能自我固摄从而形成各种疾病，诊察其脉象，右手寸口以前（阳部）脉象虚弱者即是此证。
治疗大肠虚冷，腰痛消瘦，附子汤方
附子（炮制裂开，去皮及脐，一两半） 人参 干姜（炮制裂开） 赤芍药 桂枝（去除粗皮） 甘草（炙制，各一两）
以上六味药，切碎如麻豆大小，每次服用三钱匕，用水一盏，加入大枣三枚，煎煮至剩余六成，滤去药渣，饭前温服。
治疗大肠虚冷，饮食减少，非时飧泄（完谷不化的腹泻），茱萸丸方
吴茱萸（用汤洗后焙干炒制） 诃黎勒皮 丁香 草豆蔻（去皮） 川芎 防风（去除叉枝，各一分） 石硫黄
以上七味药，捣碎过筛成粉末，用炼蜜制成梧桐子大小的丸剂，空腹时用陈米汤送服三十丸。
治疗大肠虚冷，大便滑泄，不思饮食，肠鸣腹痛，朴附丸方
厚朴（去除粗皮，用生姜汁炙制，一两） 附子（炮制裂开，去皮及脐，半两） 甘草（炙制，一两） 干姜（炮制裂开，一两）
以上四味药，捣碎过筛成粉末，用酒煮面糊为黏合剂，制成梧桐子大小的丸剂，每次服用五十丸，饭前用温米饮送下。
治疗大肠气虚，又因伤风冒雨，大肠中下血，防风丸方
防风（去除叉枝） 川芎（各一分） 黄芪（锉碎） 白术（各半两） 五味子 续断 陈皮（用汤浸泡去除白色内瓤，各一分）
以上八味药，捣碎过筛成粉末，用炼蜜和匀制成梧桐子大小的丸剂，空腹时用盐米汤送服三十丸。
治疗大肠虚寒，痢下白脓，肠内虚鸣相逐，黄连汤方
黄连（去除须根） 酸石榴皮（焙干） 赤石脂（各三两） 白茯苓（去除黑皮） 干姜（炮制裂开，各二两半） 桔梗（炒制，二两）
以上六味药，切碎如麻豆大小，每次服用五钱匕，用水一盏半，煎煮至剩余八成，滤去药渣温服，每日三次。
治疗大肠虚冷，痢下青白色，肠中虚鸣相逐，黄连汤方
黄连（去除须根，四两） 白茯苓（去除黑皮） 川芎（各三两） 酸石榴皮（二两，焙干） 地榆（五两） 伏龙肝（鸡子大）
以上六味药，将前五味药切碎如麻豆大小，每次服用五钱匕，用水一盏半，煎煮至剩余八成，加入伏龙肝粉末半钱匕，再煮沸一两次，滤去药渣温服，每日两次。
治疗大肠虚腹痛，不能久立，或腹中虚鸣，柴胡丸方
柴胡（去除苗土） 枳壳（麸炒去瓤，各一两半） 白术（三分） 白茯苓（去除黑皮，一两） 丹参（去除根头炙制） 黄芪（一两）
以上六味药，捣碎过筛成粉末，用炼蜜和匀制成梧桐子大小的丸剂，空腹时用粥饮送服三十丸，每日三次。
治疗大肠虚，大建中汤方
干姜（炮制裂开，一两半） 芍药 甘草（炙制锉碎） 桂枝（去除粗皮，各一两）
以上四味药，粗捣筛过，每次服用二钱匕，加入去核大枣三枚，饴糖一块，用水一盏，煎煮至剩余七成，滤去药渣空腹温服，每日三次。
Discussion: The disease of deficiency-cold of the Large Intestine manifests as panting in the chest, borborygmus (intestinal rumbling), thirst due to deficiency with dry lips, eye tension with susceptibility to fright, slippery diarrhea, pain in bone joints, and inability to stand for long periods. Generally, the Large Intestine is the official responsible for conduction, where changes occur. When cold pathogens lodge within it, they cause qi deficiency, leading to an inability to consolidate oneself, thereby resulting in various diseases. Upon pulse diagnosis, if the yang aspect before the right cunkou (radial artery pulse position) is deficient, this confirms the condition.
Formula for Treating Deficiency-Cold of the Large Intestine with Lower Back Pain and Emaciation: Fuzi Decoction (Cinnamon Twig and Aconite Root Decoction)
Prepared Radix Aconiti Lateralis Preparata (Pao Lie Qu Pi Qi, 1.5 liang)
Radix Ginseng (Renshen)
Rhizoma Zingiberis Preparatum (Pao Lie, dried ginger)
Radix Paeoniae Rubra (Chishao)
Ramulus Cinnamomi (Qu Cu Pi, cinnamon twig)
Radix Glycyrrhizae Preparata (Zhi Gancao, prepared licorice root, each 1 liang)
The above six herbs are crushed like hemp or bean seeds. Each dose consists of 3 qianbi (approx. 9-10g), boiled in one zhan (approx. 200ml) of water with three jujubes. Decoct until one-sixth remains, strain, and take warm before meals.
Pill Formula for Treating Deficiency-Cold of the Large Intestine with Reduced Appetite and Non-timed Sudden Diarrhea (Unformed Stool): Zhuyu Pill (Evodia Pill)
Fructus Evodiae (Washed with hot water, baked dry, and stir-fried)
Pericarpium Chebulae (Helilepi)
Flos Caryophylli (Dingxiang)
Semen Alpiniae Katadae (Qu Pi, peeled cardamom seed)
Radix Chuanxiong (Chuanxiong)
Ramulus Cinnamomi (Qu Cha, de-branched cinnamon twig, each 1 fen)
Lapis Sulphuris (Shi Liuhuang, native sulfur)
The above seven herbs are pounded and sifted into powder. Honey pills are made the size of Sophora japonica seeds. Take 30 pills with aged rice decoction on an empty stomach.
Pill Formula for Treating Deficiency-Cold of the Large Intestine with Slippery Stools, Loss of Appetite, Borborygmus, and Abdominal Pain: Pufu Pill (Magnolia Bark and Aconite Pill)
Cortex Magnoliae Officinalis (Qu Cu Pi, stir-fried with fresh ginger juice, 1 liang)
Radix Aconiti Lateralis Preparata (Pao Lie Qu Pi Qi, 0.5 liang)
Radix Glycyrrhizae Preparata (Zhi Gancao, 1 liang)
Rhizoma Zingiberis Preparatum (Pao Lie, 1 liang)
The above four herbs are pounded and sifted into powder. Use wine-boiled wheat paste as a binder to make pills the size of Sophora japonica seeds. Take 50 pills with warm rice drink before meals.
Pill Formula for Treating Qi Deficiency of the Large Intestine, Complicated by Wind Strike from Rain Exposure, with Hematochezia from the Large Intestine: Fangfeng Pill (Saposhnikovia Pill)
Radix Saposhnikoviae (Qu Cha, de-branched)
Radix Chuanxiong (each 1 fen)
Radix Astragali (Cuo, sliced)
Radix Atractylodis Macrocephalae (Banliang, half liang, each)
Fructus Schisandrae (Wuweizi)
Radix Dipsaci (Xuduan)
Pericarpium Citri Reticulatae (Tang Jin Qu Bai, soaked in water to remove white pith, each 1 fen)
The above eight herbs are pounded and sifted into powder. Mix with refined honey to make pills the size of Sophora japonica seeds. Take 30 pills with salted rice water on an empty stomach.
Decoction for Treating Deficiency-Cold of the Large Intestine with White Purulent Discharge in Dysentery and Internal Borborygmus: Huanglian Decoction (Coptis Decoction)
Rhizoma Coptidis (Qu Xu, removed rhizome fibers)
Pericarpium Granati (Bei, baked)
Lapis Kaolinis Rubrum (Chishizhi, each 3 liang)
Sclerotium Poriae Cum Radix (Hei Pi, removed black skin)
Rhizoma Zingiberis Preparatum (Pao Lie, each 2.5 liang)
Radix Platycodonis (Chao, stir-fried, 2 liang)
The above six herbs are crushed like hemp or bean seeds. Each dose consists of 5 qianbi, boiled in 1.5 zhan of water until one-eighth remains. Strain and take warm. Three times daily.
Decoction for Treating Deficiency-Cold of the Large Intestine with Green-White Dysenteric Discharge and Internal Borborygmus: Huanglian Decoction (Coptis Decoction)
Rhizoma Coptidis (Qu Xu, 4 liang)
Sclerotium Poriae Cum Radix (Hei Pi, removed black skin)
Radix Chuanxiong (each 3 liang)
Pericarpium Granati (Er Liang Bei, two liang, baked)
Radix Sanguisorbae (Wu Liang, five liang)
Cinis Fornacis (Ji Zi Da, egg-sized piece of dragon's blood soil/loong gan)
The above six herbs: Crush the first five herbs like hemp or bean seeds. Each dose consists of 5 qianbi, boiled in 1.5 zhan of water until one-eighth remains. Add 0.5 qianbi of powdered Cinis Fornacis, boil for one or two more boils, strain, and take warm. Twice daily.
Pill Formula for Treating Deficiency Abdominal Pain of the Large Intestine, Inability to Stand Long, or Internal Borborygmus: Chaihu Pill (Bupleurum Pill)
Radix Bupleuri (Qu Miao Tu, removed sprouts and soil)
Fructus Aurantii (Fu Chao Qu Rong, bran-fried, removed core, each 1.5 liang)
Radix Atractylodis Macrocephalae (San Fen, three parts)
Sclerotium Poriae Cum Radix (Hei Pi, removed black skin, 1 liang)
Radix Salviae Miltiorrhizae (Qu Gen Zhi, removed roots and stir-fried)
Radix Astragali (Yi Liang, one liang)
The above six herbs are pounded and sifted into powder. Mix with refined honey to make pills the size of Sophora japonica seeds. Take 30 pills with porridge drink on an empty stomach. Three times daily.
Decoction for Treating Deficiency of the Large Intestine: Jianzhong Decoction (Great Construct Middle Decoction)
Rhizoma Zingiberis Preparatum (Pao Lie, 1.5 liang)
Radix Paeoniae
Radix Glycyrrhizae Preparata (Zhi Cuo, prepared and sliced)
Ramulus Cinnamomi (Qu Cu Pi, removed rough bark, each 1 liang)
The above four herbs are coarsely crushed and sieved. Each dose consists of 2 qianbi, added with three pitted jujubes and a piece of maltose. Boil in one zhan of water until seven-tenths remain. Strain and take warm on an empty stomach. Three times daily.