论曰肌肉 动。命曰微风。盖邪搏分肉。卫气不通。阳气内鼓。故肌肉 动。然风之入
脉。善行数变。亦为口眼 动偏 之病也。
治八风十二痹。 腿半身不遂。历节疼痛。肌肉枯燥。皮肤 动。或筋缓急痛。不在一
处。卒起目眩。失心恍惚。妄言倒错。身生 。面上 起。或黄汁出。更相染渍。或燥或
湿。颜色赤白青黑无定。角弓反张。乍寒乍热。八风散方
麻黄(去根节) 白术(各一斤) 栝蒌根(去土) 甘草(炙) 栾荆 天雄(炮裂
去皮脐)
芦头二斤) 茵芋(
大黄(锉炒半斤) 细
砂(研) 丹参(各六两) 山茱萸
上二十五味。捣罗为细散。酒服二钱匕。日一。三十日后日再。五十日知。百日瘥。一
年平复。
治风虚肌肉 动。手足颤掉。虎骨丸方
虎胫骨(酥炙) 松节(锉酒炒) 天麻 牛膝(酒浸切焙) 赤箭 海桐皮(炒) 独
活(去
焙) 仙灵脾 甜瓜子
上一十六味。先以十五味。捣罗为细末。入研者乳香。再同研匀。酒煮面糊。丸如梧桐
子大。每服十五丸至二十丸。荆芥汤或茶酒任下。不拘时。
治风肌肉 动。头目昏眩。肢节麻痹。瘙痒疼痛。犀角丸方
犀角(镑半两) 防风(去叉) 白花蛇(酒浸去皮骨炙) 丁香 木香(各一两) 桂
(去粗皮半两) 独活(去芦头一两) 丹砂(研二两) 麝香(研一分) 龙脑(研一分)
天麻 人参(
上一十三味。先以十味。捣罗为细末。入研者药。和匀炼蜜。丸如鸡头实大。每服一丸
细嚼。荆芥茶或温酒下。不拘时。
治风虚肉 。头目昏眩。四肢拘急。或时麻痹。旋晕多痰。牙关紧痛。欠伸倦怠。生犀
丸方 犀角(镑屑) 芎 羌活(去芦头各一两) 白僵蚕(炒) 防风(去叉) 荆
芥穗(各半两)
各一分) 鸡苏叶(二两)
上一十四味。除天麻别捣外。先以十味。捣罗为细末。再入三味研者药。炼蜜半斤。入
天麻
百下。丸如鸡头实大。每服一丸细嚼。腊茶清下。不拘时。
治风热相搏。肌肉 动。头目旋眩。筋脉拘急。涎潮发搐。精神昏昧。舌强语涩。肢节
烦疼。心胸不利。凡病风气悉主之。牛黄天南星丸方
天南星(以牛胆制者用二两如无即用姜水煮透软切作片焙干) 天麻(二两) 独活(去
芦头) 白附子(炮) 白僵蚕(炒) 人参 丹砂(研各一两) 当归(洗切焙) 桑螵
蛸(炒) 干蝎(炒去土) 甘草(生用各三分) 羚羊角(镑屑) 犀角(镑屑) 麝香
(研) 牛黄(研) 雄黄(研) 龙脑(研各半两) 桂(去粗皮一分)
上一十八味。先以十三味。捣罗为细末。再入研药五味。和匀、炼蜜。丸如酸枣大。每
服一丸。不计时。细嚼、温酒下。或以鸡苏汤下。
治风虚气闭。口眼 动。偏正头痛。乳香丸方
乳香(研二分) 天麻 麻黄(去根节) 防风(去叉) 半夏 乌头(去皮脐) 天
南星 芎
上九味并生用。捣罗八味为细末。入乳香和匀。用酒煮面糊。丸如梧桐子大。每服十五
丸。荆芥茶下。空心食前服。
治风循经络。肌肉 动。头目昏眩。手足麻痹。天麻丸方
天麻 芎 (各一两) 荆芥穗 鸡苏叶(各二两) 白附子(炮) 甘草(炙各半两)
上六味。捣罗为细末。炼蜜丸如樱桃大。每服一丸。嚼破茶酒任下。
治头目运眩。欲倒。痰逆恶心。偏正头痛。眉骨痛。肢体倦怠。鼻塞气道不通。或面上
游风目 。常服治风化痰。清神志。芎犀丸方
犀角(镑屑一分) 芎 (三两) 桔梗(锉炒一分) 甘草(炙一分) 鸡苏叶(罗
去土三两)
风(去叉一分锉)
上一十味。除丹砂研外。九味捣罗为细末。和匀炼蜜。丸如樱桃大。每服一丸。食后细
嚼、茶酒任下。
治风气肌肉 动。头目昏眩。四肢烦疼。荆芥汤方
荆芥穗 旋复花(各四两) 前胡(去芦头) 甘草(炙) 麻黄(去根节) 芍药 芎
半夏(汤洗七遍各一两)
上八味。粗捣筛。每服三钱匕。水一盏。入葱白三寸。鸡苏三叶。同煎至七分。去滓温
服。
治风气肌肉 动。头目昏眩。利胸膈。化风丸方
鸡苏叶(二两) 羌活(去芦头一两半) 芎 (一两半) 羚羊角(镑屑一两) 防
风(去叉
僵蚕(炒一两) 龙脑(研)
上一十二味。先以十味捣罗为末。入研者龙脑麝香。再同研。炼蜜丸如鸡头大。以丹砂
为衣。每服一丸或二丸。茶酒任下。不拘时。
论述说:肌肉跳动,称为微风。这是因为邪气搏结于分肉之间,卫气运行不畅,阳气在体内鼓动,所以导致肌肉跳动。然而风邪侵入经脉,具有善行数变的特性,也会引起口眼歪斜、肢体抽搐偏瘫的疾病。
治疗八风及十二痹证,腿脚无力、半身不遂,历节疼痛,肌肉干枯粗糙,皮肤跳动,或者筋脉松弛或拘急疼痛,病位不固定,突然发作时目眩,心神失守、恍惚,胡言乱语、错乱颠倒,身上生出疮疡,面部浮肿起疹,或者有黄色汁液流出,互相沾染浸渍,或者干燥或者潮湿,面色赤白青黑不定,角弓反张,忽冷忽热。用八风散方:
麻黄(去除根和节)一斤,白术一斤,栝蒌根(去除泥土),甘草(炙),栾荆,天雄(炮裂,去皮和脐),芦头二斤,茵芋,大黄(锉碎炒制半斤),细辛,砂(研磨),丹参各六两,山茱萸。
以上二十五味药,捣碎过筛成细散。用酒送服二钱匕,每日一次。三十日后改为每日两次,五十日见效,百日痊愈,一年完全恢复健康。
治疗风虚引起的肌肉跳动,手足颤抖,虎骨丸方:
虎胫骨(酥炙),松节(锉碎,酒炒),天麻,牛膝(酒浸后切片焙干),赤箭,海桐皮(炒),独活(去芦头焙干),仙灵脾,甜瓜子。
以上十六味药,先将十五味药捣碎过筛成细末,加入研碎的乳香,再次共同研磨均匀。用酒煮面糊,制成梧桐子大小的丸药。每次服用十五丸至二十丸,用荆芥汤或茶、酒送服均可,不限时间。
治疗风邪引起的肌肉跳动,头目昏眩,肢节麻痹,瘙痒疼痛,犀角丸方:
犀角(镑成薄片半两),防风(去除叉枝),白花蛇(酒浸,去皮骨后炙),丁香,木香各一两,桂枝(去除粗皮半两),独活(去芦头一两),丹砂(研磨二两),麝香(研磨一分),龙脑(研磨一分),天麻,人参。
以上十三味药,先将十味药捣碎过筛成细末,加入已研磨的药物,混合均匀,用炼蜜制成鸡头实大小的丸药。每次服用一丸,细细咀嚼,用荆芥茶或温酒送服,不限时间。
治疗风虚肉颤,头目昏眩,四肢拘急,有时麻痹,眩晕多痰,牙关紧闭疼痛,呵欠伸展倦怠,生犀丸方:
犀角(镑成屑),川芎,羌活(去芦头各一两),白僵蚕(炒),防风(去除叉枝),荆芥穗各半两,[此处原文缺味名,依上下文推测可能为某药]各一分,鸡苏叶二两。
以上十四味药,除天麻单独捣碎外,先将十味药捣碎过筛成细末,再放入三种需研磨的药物,加入半斤炼蜜,将天麻捣百下,制成鸡头实大小的丸药。每次服用一丸,细细咀嚼,用腊茶清送服,不限时间。
治疗风热相搏,肌肉跳动,头目旋转眩晕,筋脉拘急,涎潮引发抽搐,精神昏昧,舌强语涩,肢节烦疼,心胸不利,凡是风气引发的疾病都主治。牛黄天南星丸方:
天南星(用牛胆制的用二两,如果没有就用姜水煮透软后切片焙干),天麻二两,独活(去芦头),白附子(炮),白僵蚕(炒),人参,丹砂(研磨各一两),当归(洗切焙),桑螵蛸(炒),干蝎(炒去土),甘草(生用各三分),羚羊角(镑屑),犀角(镑屑),麝香(研),牛黄(研),雄黄(研),龙脑(研各半两),桂枝(去粗皮一分)。
以上十八味药,先将十三味药捣碎过筛成细末,再放入五种需研磨的药物,混合均匀,用炼蜜制成酸枣大小的丸药。每次服用一丸,不限时间,细细咀嚼,用温酒送服,或者用鸡苏汤送服。
治疗风虚气闭,口眼歪斜跳动,偏头痛或正头痛,乳香丸方:
乳香(研磨二分),天麻,麻黄(去根节),防风(去叉枝),半夏,乌头(去皮脐),天南星,川芎。
以上九味药均生用,将八味药捣碎过筛成细末,加入乳香混合均匀。用酒煮面糊,制成梧桐子大小的丸药。每次服用十五丸,用荆芥茶送服,空腹饭前服用。
治疗风邪沿经络行走,肌肉跳动,头目昏眩,手足麻痹,天麻丸方:
天麻,川芎各一两,荆芥穗,鸡苏叶各二两,白附子(炮),甘草(炙各半两)。
以上六味药,捣碎过筛成细末,用炼蜜制成樱桃大小的丸药。每次服用一丸,嚼破后用茶或酒送服均可。
治疗头目晕眩,想要跌倒,痰逆恶心,偏头痛或正头痛,眉骨痛,肢体倦怠,鼻塞气道不通,或者面上游风导致眼睛不适,常服可治风化痰,清神志。芎犀丸方:
犀角(镑屑一分),川芎三两,桔梗(锉炒一分),甘草(炙一分),鸡苏叶(罗去土三两),[此处原文缺味名,依上下文推测]风(去叉一分锉)。
以上十味药,除丹砂研磨外,其余九味捣碎过筛成细末,混合均匀,用炼蜜制成樱桃大小的丸药。每次服用一丸,食后细细咀嚼,用茶或酒送服均可。
治疗风气引起的肌肉跳动,头目昏眩,四肢烦疼,荆芥汤方:
荆芥穗,旋复花各四两,前胡(去芦头),甘草(炙),麻黄(去根节),芍药,川芎,半夏(汤洗七遍各一两)。
以上八味药,粗捣筛。每次服用三钱匕,用水一盏,加入葱白三寸,鸡苏三叶,同煎至七分,去渣温服。
治疗风气引起的肌肉跳动,头目昏眩,利胸膈,化风丸方:
鸡苏叶二两,羌活(去芦头一两半),川芎一两半,羚羊角(镑屑一两),防风(去叉),[此处原文缺味名],僵蚕(炒一两),龙脑(研)。
以上十二味药,先将十味药捣碎过筛成末,加入研磨的龙脑、麝香,再次共同研磨。用炼蜜制成鸡头大小的丸药,以丹砂为衣。每次服用一丸或二丸,用茶或酒送服均可,不限时间。
Discourse states: Muscle twitching is called "slight wind" (Wei Feng). This occurs because pathogenic factors contend with the intermuscular spaces, causing Wei Qi (Defensive Qi) to be obstructed and Yang Qi to surge internally, thus resulting in muscle twitching. However, when wind pathogens enter the meridians, they are characterized by rapid movement and frequent changes, and can also cause diseases such as facial paralysis (Kou Yan Pian Dou) and hemiplegia.
Treatment for Eight Winds and Twelve Bi syndromes, leg weakness, hemiplegia, joint pain (Li Jie), dry and rough muscles, skin twitching, or tendons that are either flaccid or spasmodic and painful, with lesions not fixed in one location; sudden onset of vertigo, loss of heart spirit (Shi Xin) with confusion, delirious speech and errors; sores arising on the body, swelling and rashes on the face, or exudation of yellow fluid that spreads and stains; conditions that are either dry or damp, with complexion varying unpredictably between red, white, green, and black; opisthotonos; alternating chills and fever. Use the Ba Feng San (Eight Wind Powder) formula:
Ephedrae Herba (Mahuang, 麻黄) [remove roots and nodes] 1 jin, Atractylodis Macrocephalae Rhizoma (Baizhu, 白术) 1 jin, Trichosanthis Radix (Gualou Gen, 栝蒌根) [remove soil], Glycyrrhizae Radix et Rhizoma (Gancao, 甘草) [roasted], Luan Jing, Aconiti Lateralis Radix Preparata (Tianxiong, 天雄) [cracked by fire, remove peel and navel], Scrophulariae Radix (Lutou, 芦头) 2 jin, Ilicis Cornuti Folium (Yinyu, 茵芋), Rhei Radix et Rhizoma (Dahuang, 大黄) [cut and stir-fried, half jin], Cinnabaris (Sha, 砂) [ground], Salviae Miltiorrhizae Radix (Danshen, 丹参) each 6 liang, Corni Fructus (Shanzhuyu, 山茱萸).
The above twenty-five ingredients are crushed, sieved into a fine powder. Take 2 qianbi (a small measuring spoon) with wine, once daily. After thirty days, take twice daily. Effect seen after fifty days, cured after one hundred days, fully recovered after one year.
For wind-deficiency causing muscle twitching and trembling of hands and feet, use Huguj Wan (Tiger Bone Pill) formula:
Pantheris Os (Hujinggu, 虎胫骨) [roasted with butter], Pinelliae Rhizoma Preparatum (Songjie, 松节 - *Note: Songjie usually refers to Pine Joint, text says Pine Joint but lists Tiger Bone first, assuming standard pine joint here based on context of tremors*) [cut, stir-fried with wine], Gastrodiae Rhizoma (Tianma, 天麻), Achyranthis Bidentatae Radix (Niuxi, 牛膝) [soaked in wine, sliced, dried], Araliasis Radix (Chijian, 赤箭), Semecarpus Anacardii Cortex (Haitongpi, 海桐皮) [stir-fried], Angelicae Pubescentis Radix (Duohuo, 独活) [remove rhizome, dried], Epimedii Folium (Xianlingpi, 仙lingpi), Benincasae Semen (Tianguazi, 甜瓜子).
The above sixteen ingredients: First, crush fifteen ingredients into a fine powder. Add ground Frankincense (Ruxiang, 乳香) and grind together uniformly. Make pills using wheat flour paste boiled in wine, sized like paulownia seeds. Take 15-20 pills per dose, with Schizonepeta Tea, tea, or wine, at any time.
For wind causing muscle twitching, dizziness of head and eyes, numbness of limbs and joints, itching and pain, use Xijiao Wan (Rhinoceros Horn Pill) formula:
Rhinoceri Cornu (Xijiao, 犀角) [shaved, half liang], Saposhnikoviae Radix (Fangfeng, 防风) [remove forked branches], Daboia Savina (Baihuashe, 白花蛇) [soaked in wine, remove skin and bones, roasted], Symplocos Terminalis Flos (Dingxiang, 丁香), Aucklandiae Radix (Muxiang, 木香) each 1 liang, Cinnamomi Ramulus (Guizhi, 桂枝) [remove coarse bark, half liang], Angelicae Pubescentis Radix (Duohuo, 独活) [remove rhizome, 1 liang], Cinnabaris (Dansha, 丹砂) [ground, 2 liang], Moschus (Shexiang, 麝香) [ground, 1 fen], Borneolum Syntheticum (Longnao, 龙脑) [ground, 1 fen], Gastrodiae Rhizoma (Tianma, 天麻), Ginseng Radix et Rhizoma (Renshen, 人参).
The above thirteen ingredients: First, crush ten ingredients into a fine powder. Add the ground medicines, mix evenly, and bind with refined honey into pills sized like corn kernels. Take one pill per dose, chew thoroughly, with Schizonepeta Tea or warm wine, at any time.
For wind-deficiency causing muscle tremors, dizziness of head and eyes, stiffness of four limbs, occasional numbness, vertigo with excessive phlegm, tight jaw and pain, yawning and fatigue, use Sheng Xi Wan (Fresh Rhinoceros Horn Pill) formula:
Rhinoceri Cornu (Xijiao, 犀角) [shaved], Ligustici Chuanxiong Rhizoma (Chuanxiong, 川芎), Notopterygii Rhizoma et Radix (Qianghuo, 羌活) [remove rhizome, each 1 liang], Bombyx Batryticatus (Baijiangcan, 白僵蚕) [stir-fried], Saposhnikoviae Radix (Fangfeng, 防风) [remove forked branches], Schizonepetae Spica (Jingjiesui, 荆芥穗) each half liang, [Missing ingredient in source] each 1 fen, Heteromallae Herba (Jisuye, 鸡苏叶) 2 liang.
The above fourteen ingredients: Except for Gastrodiae Rhizoma (Tianma, 天麻) which is pounded separately, first crush ten ingredients into a fine powder. Then add three ground ingredients, mix with half a jin of refined honey, pound Tianma one hundred times, and form pills sized like corn kernels. Take one pill per dose, chew thoroughly, with winter tea infusion, at any time.
For wind-heat contending, muscle twitching, spinning vertigo, tendon and vessel stiffness, salivary tide causing convulsions, mental confusion, stiff tongue and slurred speech, vexing pain in limbs and joints, chest discomfort, governing all diseases caused by wind pathogen. Use Niuhuang Tiannanxing Wan (Calculus Bovis and Pinellia Pill) formula:
Pinelliae Tuber (Tiannanxing, 天南星) [processed with ox gall, 2 liang; if unavailable, boil in ginger water until soft, slice, and dry] 2 liang, Gastrodiae Rhizoma (Tianma, 天麻) 2 liang, Angelicae Pubescentis Radix (Duohuo, 独活) [remove rhizome], Typhonii Rhizoma (Baifuzi, 白附子) [prepared], Bombyx Batryticatus (Baijiangcan, 白僵蚕) [stir-fried], Ginseng Radix et Rhizoma (Renshen, 人参), Cinnabaris (Dansha, 丹砂) [ground, each 1 liang], Angelicae Sinensis Radix (Danggui, 当归) [wash, cut, dry], Mantidis Oötheca (Sangpiaoxiao, 桑螵蛸) [stir-fried], Scorpio (Ganxie, 干蝎) [stir-fried, remove dirt], Glycyrrhizae Radix et Rhizoma (Gancao, 甘草) [raw, each 3 fen], Saigae Tataricae Cornu (Lingyangjiao, 羚羊角) [shaved], Rhinoceri Cornu (Xijiao, 犀角) [shaved], Moschus (Shexiang, 麝香) [ground], Calculus Bovis (Niuhuang, 牛黄) [ground], Realgar (Xionghuang, 雄黄) [ground], Borneolum Syntheticum (Longnao, 龙脑) [ground, each half liang], Cinnamomi Ramulus (Guizhi, 桂枝) [remove coarse bark, 1 fen].
The above eighteen ingredients: First, crush thirteen ingredients into a fine powder. Then add five ground ingredients, mix evenly, and bind with refined honey into pills sized like sour jujube seeds. Take one pill per dose, at any time, chew thoroughly, with warm wine, or with Heteromallae Decoction.
For wind-deficiency causing qi obstruction, facial paralysis and twitching, lateral or central headache, use Ruxiang Wan (Frankincense Pill) formula:
Frankincense (Ruxiang, 乳香) [ground, 2 fen], Gastrodiae Rhizoma (Tianma, 天麻), Ephedrae Herba (Mahuang, 麻黄) [remove roots and nodes], Saposhnikoviae Radix (Fangfeng, 防风) [remove forked branches], Pinelliae Rhizoma (Banxia, 半夏), Aconiti Radix (Wutou, 乌头) [remove peel and navel], Pinelliae Tuber (Tiannanxing, 天南星), Ligustici Chuanxiong Rhizoma (Chuanxiong, 川芎).
The above nine ingredients are used raw. Crush eight ingredients into a fine powder, mix with frankincense. Make pills using wheat flour paste boiled in wine, sized like paulownia seeds. Take 15 pills per dose, with Schizonepeta Tea, on an empty stomach before meals.
For wind traveling along meridians, muscle twitching, dizziness of head and eyes, numbness of hands and feet, use Tianma Wan (Gastrodia Pill) formula:
Gastrodiae Rhizoma (Tianma, 天麻), Ligustici Chuanxiong Rhizoma (Chuanxiong, 川芎) each 1 liang, Schizonepetae Spica (Jingjiesui, 荆芥穗), Heteromallae Herba (Jisuye, 鸡苏叶) each 2 liang, Typhonii Rhizoma (Baifuzi, 白附子) [prepared], Glycyrrhizae Radix et Rhizoma (Gancao, 甘草) [roasted, each half liang].
The above six ingredients are crushed, sieved into a fine powder, and bound with refined honey into pills sized like cherries. Take one pill per dose, chew thoroughly, with tea or wine, at will.
For dizziness and vertigo, feeling of falling, rebellious phlegm and nausea, lateral or central headache, supraorbital pain, limb fatigue, nasal congestion and blocked airways, or wandering wind on the face affecting the eyes. Regular use treats wind, resolves phlegm, and clears the spirit. Use Xiongxi Wan (Chuanxiong and Rhinoceros Horn Pill) formula:
Rhinoceri Cornu (Xijiao, 犀角) [shaved, 1 fen], Ligustici Chuanxiong Rhizoma (Chuanxiong, 川芎) 3 liang, Platycodonis Radix (Jiegeng, 桔梗) [cut and stir-fried, 1 fen], Glycyrrhizae Radix et Rhizoma (Gancao, 甘草) [roasted, 1 fen], Heteromallae Herba (Jisuye, 鸡苏叶) [sieved, remove dirt, 3 liang], [Missing ingredient in source] Saposhnikoviae Radix (Fangfeng, 防风) [remove forked branches, cut, 1 fen].
The above ten ingredients: Except for Cinnabaris (Dansha, 丹砂) which is ground, crush the other nine ingredients into a fine powder, mix evenly, and bind with refined honey into pills sized like cherries. Take one pill per dose after meals, chew thoroughly, with tea or wine, at will.
For wind pathogen causing muscle twitching, dizziness of head and eyes, vexing pain in four limbs, use Jingjie Tang (Schizonepeta Decoction) formula:
Schizonepetae Spica (Jingjiesui, 荆芥穗), Inulae Flos (Xuanfuhua, 旋复花) each 4 liang, Peucedani Radix (Qianhu, 前胡) [remove rhizome], Glycyrrhizae Radix et Rhizoma (Gancao, 甘草) [roasted], Ephedrae Herba (Mahuang, 麻黄) [remove roots and nodes], Paeoniae Radix Alba (Shaoyao, 芍药), Ligustici Chuanxiong Rhizoma (Chuanxiong, 川芎), Pinelliae Rhizoma (Banxia, 半夏) [washed in hot water seven times, each 1 liang].
The above eight ingredients are coarsely crushed and sieved. Take 3 qianbi per dose, with one cup of water, add three cun of scallion white and three leaves of Heteromallae, decoct together until reduced to 70%, remove dregs, and take warm.
For wind pathogen causing muscle twitching, dizziness of head and eyes, benefiting the chest and diaphragm, use Huafeng Wan (Wind-Resolving Pill) formula:
Heteromallae Herba (Jisuye, 鸡苏叶) 2 liang, Notopterygii Rhizoma et Radix (Qianghuo, 羌活) [remove rhizome, 1.5 liang], Ligustici Chuanxiong Rhizoma (Chuanxiong, 川芎) 1.5 liang, Saigae Tataricae Cornu (Lingyangjiao, 羚羊角) [shaved, 1 liang], Saposhnikoviae Radix (Fangfeng, 防风) [remove forked branches], [Missing ingredient in source], Bombyx Batryticatus (Baijiangcan, 白僵蚕) [stir-fried, 1 liang], Borneolum Syntheticum (Longnao, 龙脑) [ground].
The above twelve ingredients: First, crush ten ingredients into a powder. Add ground Borneolum Syntheticum (Longnao, 龙脑) and Moschus (Shexiang, 麝香), grind together again. Bind with refined honey into pills sized like corn kernels, coated with Cinnabaris (Dansha, 丹砂). Take one or two pills per dose, with tea or wine, at any time.