生石膏（大剂，六两至八两，中剂，二两至四两，小剂，八钱至一两二钱） 栀子 小生地（大剂，六钱至一
两，中剂，三钱至五钱，小剂，二钱至四钱五分） 桔梗 乌犀角（大剂，六钱至八钱，中剂，三钱至四钱，小剂，
二钱至四钱） 黄芩 真川连（大剂，四钱至六钱，中剂，二钱至四钱，小剂，一钱至一钱半） 知母 赤芍 元参
连翘 甘草 丹皮 鲜竹叶
先煮石膏数十沸，后下诸药，犀角磨汁和服。
余师愚曰∶此十二经泄火之药也。凡一切火热，表里俱感，狂躁烦心，口干咽痛，大热干呕，错语不眠，吐血衄
血，热甚发斑，不论始终，以此为主方。盖斑疹虽出于胃，亦诸经之火有以助之，重用石膏，直入胃经，使其敷布
于十二经，退其淫热，佐以黄连、犀角、黄芩，泄心肺火于上焦，丹皮及栀子、赤芍，泄肝经之火，连翘、元参，解散
浮游之火，生地、知母，抑阳扶阴，泄其亢甚之火，而救欲绝之水，桔梗、竹叶，载药上行，使以甘草和胃，此大寒解
毒之剂。重用石膏，则甚者先平，而诸经之火，自无不安矣。证疫若初起，恶寒发热，头痛如劈，烦躁谵妄，身热肢冷，
舌刺唇焦，上呕下泄，六脉沉细而数，即用大剂，沉而数者，即用中剂，浮大而数者，用小剂，如斑一出，即加大
青叶，并少佐升麻四五分，引毒外透，此内化外解，浊降清升之法，治一得一，治十得十，以视升提发表而加剧者，何
为俯取刍荛之一得乎？
生石膏（大剂量使用，六两至八两；中等剂量，二两至四两；小剂量，八钱至一两二钱） 栀子 小生地（大剂量，六钱至一两；中等剂量，三钱至五钱；小剂量，二钱至四钱五分） 桔梗 乌犀角（大剂量，六钱至八钱；中等剂量，三钱至四钱；小剂量，二钱至四钱） 黄芩 真川连（大剂量，四钱至六钱；中等剂量，二钱至四钱；小剂量，一钱至一钱半） 知母 赤芍 元参 连翘 甘草 丹皮 鲜竹叶
先煎煮石膏数十沸，然后加入其余药物，犀角磨成汁液混合服用。
余师愚说：这是清泄十二经火邪的药物。凡是各种火热之邪，表里同时受感，出现狂躁、心烦、口干、咽痛、高热干呕、胡言乱语、失眠、吐血、鼻出血，热毒极盛导致发斑，无论病程初期还是后期，都以此方为主方。因为斑疹虽然出于胃，但也由其他各经的火邪助长所致。重用石膏，直接入胃经，使其分布到十二经，退去过盛的火热；辅以黄连、犀角、黄芩，清泄上焦心肺之火；丹皮、栀子、赤芍，清泄肝经之火；连翘、元参，解散游走不定的浮火；生地、知母，抑制阳亢、扶持阴液，清泄极度亢奋的火邪，挽救即将枯竭的阴水；桔梗、竹叶，引导药力上行；以甘草调和胃气。这是大寒解毒的方剂。重用石膏，则严重的症状先被平抑，各经的火邪自然得以安宁。如果是疫病初起，出现恶寒发热、头痛如劈、烦躁谵妄、身热肢冷、舌面生刺、嘴唇焦裂、上吐下泻、六脉沉细而数，就立即使用大剂量；脉象沉而数的，使用中剂量；脉象浮大而数的，使用小剂量。如果斑疹一出，就加大青叶，并少量佐以升麻四五分，引导毒邪向外透发。这是内化外解、浊降清升的方法，治疗一个成功一个，治疗十个成功十个，与那些使用升提发表法反而使病情加重的情况相比，这难道不是值得采纳的一得之见吗？
Shigao (Gypsum Fibrosum) [Large dose: 6–8 liang; Medium dose: 2–4 liang; Small dose: 8 qian – 1.2 liang] Zhizi (Gardeniae Fructus) Xiaoshengdi (Rehmanniae Radix Preparata, small size) [Large dose: 6 qian – 1 liang; Medium dose: 3–5 qian; Small dose: 2–4.5 qian] Jiegeng (Platycodonis Radix) Wuxijiao (Rhinocerotis Cornu, black rhinoceros horn) [Large dose: 6–8 qian; Medium dose: 3–4 qian; Small dose: 2–4 qian] Huangqin (Scutellariae Radix) Zhenchuanlian (Coptidis Rhizoma, genuine from Sichuan) [Large dose: 4–6 qian; Medium dose: 2–4 qian; Small dose: 1–1.5 qian] Zhimu (Anemarrhenae Rhizoma) Chishao (Paeoniae Radix Rubra) Yuanshen (Scrophulariae Radix) Lianqiao (Forsythiae Fructus) Gancao (Glycyrrhizae Radix et Rhizoma) Danpi (Moutan Cortex) Xianzhuye (Bambusae Folium Frescum)
Boil Shigao (Gypsum Fibrosum) for dozens of boils first, then add the remaining herbs. Grind Wuxijiao (Rhinocerotis Cornu) into juice and mix with the decoction for administration.
Yu Shiyu stated: This is a formula that drains fire from the twelve meridians. It is indicated for all types of heat-fire pathogens affecting both the exterior and interior simultaneously, manifesting as mania, restlessness, vexation, dry mouth, sore throat, high fever with dry retching, delirious speech, insomnia, hematemesis, epistaxis, and severe heat toxin causing macules (rash). Regardless of whether it is in the early or late stage of the disease, this formula should be used as the primary prescription. Although macules originate from the Stomach, they are also assisted by fire from various other meridians. By heavily using Shigao (Gypsum Fibrosum), which directly enters the Stomach meridian, its effects are distributed throughout the twelve meridians to retreat excessive heat. It is assisted by Huanglian (Coptidis Rhizoma), Wuxijiao (Rhinocerotis Cornu), and Huangqin (Scutellariae Radix) to drain heart and lung fire in the Upper Jiao; Danpi (Moutan Cortex), Zhizi (Gardeniae Fructus), and Chishao (Paeoniae Radix Rubra) to drain liver fire; Lianqiao (Forsythiae Fructus) and Yuanshen (Scrophulariae Radix) to dissipate floating and wandering fire; Xiaoshengdi (Rehmanniae Radix Preparata) and Zhimu (Anemarrhenae Rhizoma) to suppress hyperactive yang and support yin fluids, draining extreme fire and rescuing nearly exhausted water (yin); Jiegeng (Platycodonis Radix) and Xianzhuye (Bambusae Folium Frescum) to guide the medicinal action upward; and Gancao (Glycyrrhizae Radix et Rhizoma) to harmonize the stomach. This is a major cold detoxification formula. By heavily using Shigao (Gypsum Fibrosum), the most severe symptoms are pacified first, and the fire in all meridians naturally becomes tranquil. If epidemic disease (Yi Bing) begins with aversion to cold and fever, headache as if splitting, restlessness and delirium, body heat with cold limbs, prickly tongue with scorched lips, upper vomiting and lower diarrhea, and six pulses that are deep, fine, and rapid, use the large dose immediately. For deep and rapid pulses, use the medium dose; for floating, large, and rapid pulses, use the small dose. Once macules appear, add Daqingye (Isatidis Folium) and slightly assist with Shengma (Cimicifugae Rhizoma), 4–5 fen, to guide the toxin outward. This is the method of internal transformation and external resolution, descending turbidity and ascending clarity. Treatment yields success in every case; treating ten results in ten successes. Compared to those methods that use lifting and releasing the exterior which exacerbate the condition, is this not a valuable insight worthy of adoption?