陈良甫曰∶妊娠烦闷者，以四月受少阴君火以养精，六月受少阳相火以养气。若母心惊胆虚，多有是证。
李太素曰∶烦者，心中烦乱不安也。由受胎后，血热于心，心气不清，故人郁闷撩乱不宁。因妊娠而烦，故
曰子烦，非子在腹中烦也。古云∶四月受少阴君火以养精，六月受少阳相火以养气，故烦。夫烦多属火，今胎受
君相之火，岂有母烦之理。况母既以二火养胎，则火泻矣，又何烦之有？若曰母虚而烦，则当每月皆然，何独
于四月六月而虚且烦，亦不拘于四月六月也，似说不通。
齐仲甫曰∶妊娠烦闷有四证，有心中烦、胸中烦，有子烦，诸属于热。若脏虚而热气乘心，令人烦者，名虚
烦。若积痰饮，呕吐痰沫者，名胸中烦。或血积停饮，寒热相抟，致胎气不安，谓子烦，用犀角散、竹沥汤之类。
单养贤曰∶是心肺虚热，或痰积于胸。若三月而烦者，但热而已。若痰饮而烦者，吐涎恶食，烦躁不安也。
大凡妊娠，既停痰积饮，又寒热相抟，气郁不舒，或烦躁，或呕吐涎沫，剧则胎动不安，均为子烦也。
朱丹溪曰∶子烦由胎元壅郁，热气上冲。以致烦闷，法当清热疏郁，以安胎，犀角散主之。
薛立斋曰∶前证若因内热，用竹叶汤。气滞用紫苏饮。痰滞用二陈加条芩、枳壳。气
郁用分气饮加川芎。脾胃虚弱，用六君子，加紫苏、山栀。
陈良甫说：妊娠期间出现烦闷症状，是因为在怀孕第四个月时受少阴君火滋养精气，第六个月时受少阳相火滋养气机。如果孕妇心惊胆虚，常常会出现这种证候。
李太素说：所谓“烦”，是指心中烦乱不安。这是由于受孕之后，血热在心，心气不清净，所以人感到郁闷撩乱、不得安宁。因为是在妊娠期间出现的烦闷，所以称为“子烦”，并不是指胎儿在腹中感到烦躁。古人说：第四个月受少阴君火以养精，第六个月受少阳相火以养气，所以会产生烦闷。大凡“烦”多属于火邪，如今胎儿接受了君火和相火的滋养，怎么会有母亲感到烦躁的道理呢？况且母亲既然用这两种火来滋养胎儿，那么火气就会随着滋养过程而消耗（泻），又怎么会烦躁呢？如果说这是因为母亲虚弱而导致烦躁，那么每个月都应该是这样，为什么偏偏在第四个月和第六个月才虚弱且烦躁呢？而且也不仅仅局限于第四个月和第六个月，这种说法似乎讲不通。
齐仲甫说：妊娠期间的烦闷主要有四种证候，有心中烦、胸中烦，还有子烦，这些大多归属于热证。如果是脏腑虚弱而热气乘袭心脏，使人感到烦躁的，称为“虚烦”。如果有积痰停饮，呕吐痰沫的，称为“胸中烦”。或者是血液积聚、停饮，寒热相互搏结，导致胎气不安，称为“子烦”，治疗可用犀角散、竹沥汤之类的方剂。
单养贤说：这是心肺虚热，或者痰积于胸部。如果在怀孕第三个月出现烦闷，只是热象而已。如果是因痰饮导致的烦闷，则会吐涎沫、厌恶饮食、烦躁不安。大凡妊娠期间，既有痰饮积聚，又有寒热相互搏结，气机郁滞不舒，或者烦躁，或者呕吐涎沫，严重时则胎动不安，这些都统称为“子烦”。
朱丹溪说：子烦是由于胎元壅滞郁结，热气上冲，从而导致烦闷。治疗方法应当清热疏解郁结，以安胎，主方用犀角散。
薛立斋说：上述证候如果是因为内热引起的，使用竹叶汤。如果是气滞，使用紫苏饮。如果是痰滞，使用二陈汤加黄芩、枳壳。如果是气郁，使用分气饮加川芎。如果是脾胃虚弱，使用六君子汤，加紫苏、山栀。
Chen Liangfu stated: During pregnancy, the sensation of vexation and stuffiness arises because in the fourth month, Shaoyin Junhuo (Ministerial Fire of Shaoyin) nourishes the essence, and in the sixth month, Shaoyang Xianghuo (Ministerial Fire of Shaoyang) nourishes the qi. If the mother suffers from fright and gallbladder deficiency, this syndrome often occurs.
Li Taisu stated: "Vexation" refers to a state of mental restlessness and unease within the heart. This is caused by blood heat affecting the heart after conception, leading to a lack of clarity in heart qi, resulting in depression, agitation, and inability to find peace. Because this vexation occurs during pregnancy, it is termed "Zifan" (Pregnancy Vexation), not implying that the fetus itself is vexed in the womb. The ancients said: In the fourth month, Shaoyin Junhuo nourishes the essence; in the sixth month, Shaoyang Xianghuo nourishes the qi, thus causing vexation. Generally, vexation belongs to fire. Since the fetus receives the nourishment of both Junhuo and Xianghuo, how could the mother feel vexed? Moreover, since the mother uses these two fires to nourish the fetus, the fire energy would be dissipated through this process, so why would there be vexation? If one argues that the mother's deficiency causes vexation, then it should occur every month. Why specifically in the fourth and sixth months does the mother become deficient and vexed? Furthermore, it is not limited to only these two months. Thus, this explanation seems logically inconsistent.
Qi Zhongfu stated: There are four types of vexation and stuffiness during pregnancy: vexation in the heart, vexation in the chest, and Zifan (Pregnancy Vexation); all belong to heat syndromes. If organ deficiency allows heat pathogens to invade the heart, causing vexation, it is named "Xu Fan" (Deficiency Vexation). If there is accumulated phlegm-fluid retention with vomiting of phlegm-saliva, it is named "Xiongzhong Fan" (Chest Vexation). If blood stasis and fluid retention interact with cold and heat, disturbing fetal qi and causing instability, it is called "Zifan," treated with formulas such as Xijiao San (Rhinoceros Horn Powder) or Zhuli Tang (Bamboo Juice Decoction).
Shan Yangxian stated: This involves deficiency-heat of the heart and lungs, or phlegm accumulation in the chest. If vexation occurs in the third month of pregnancy, it is merely due to heat. If vexation is caused by phlegm-fluids, symptoms include spitting saliva, aversion to food, and restless agitation. Generally, during pregnancy, the presence of accumulated phlegm and fluids, combined with the struggle between cold and heat, leads to stagnant and unsmooth qi mechanism. Symptoms may include vexation or vomiting of saliva-phlegm; in severe cases, fetal movement becomes unstable. All these conditions are collectively referred to as "Zifan."
Zhu Danxi stated: Zifan results from the obstruction and stagnation of the fetal origin, with heat qi rushing upward, leading to vexation and stuffiness. The treatment method should focus on clearing heat and resolving stagnation to calm the fetus, primarily using Xijiao San (Rhinoceros Horn Powder).
Xue Lizhai stated: For the aforementioned syndromes, if caused by internal heat, use Zhuye Tang (Bamboo Leaf Decoction). If caused by qi stagnation, use Zisu Yin (Perilla Infusion). If caused by phlegm stagnation, use Erchen Tang (Two-Aged Phlegm Decoction) added with Huangqin (Scutellaria Root) and Zhike (Aurantium Fructus). If caused by qi depression, use Fenqi Yin (Qi-Dispelling Infusion) added with Chuanxiong (Ligusticum Rhizome). If caused by spleen and stomach weakness, use Liujunzi Tang (Six Gentlemen Decoction) added with Zisu (Perilla Leaf) and Shanzhi (Gardenia Fruit).