朱怀竹壮年，客外不谨而生杨梅疮，恐人知之，又欲回家，乃求速愈。每日用药外熏，
熏而
不效，用药水频洗，洗而不瘳，乃以末药点之，一日凡服煎药三帖。如斯两月，不惟疮不能
瘳，毒且赶入内。在下则肛脱二寸余，周匝疮满如蕈，弗克收入，因而不能行坐；在上则毒
入于肺，喘咳气涌，胸膈胀闷，不能仰卧，内热而外恶寒，寝食俱废，合目即谵语。阴囊疙
瘩红肿胀痛，两足疮延肿大，精神恍惚，软床舁归。乃兄少竹逆予为诊，六脉俱洪大而数。
语
少竹曰∶病至重，幸壮年，犹可治也。今予尚未可敷药，俟彼胸中瘀血毒物出后乃可服。否
则彼以予药动血而反致疑。顾城中诸友鲜有识此病者，一误则大事去矣。慎之，慎之!少竹
素信予，固请予药而不与其服。怀竹见予不发药，乃延张、程两公为治。晌午服药，晡刻大
发喘咳，吐出紫黑血块如脓之类碗余，满房腥秽不可近。怀竹心慌，少竹慰之曰∶毋恐。孙
君先已预言你胸中胀闷者由熏药逼毒入内，上迫于肺，痰与瘀血壅遏肺窍，将欲成脓，故喘
咳不能伏枕。顾脉洪大而数，从可知也，必俟吐后乘而消之，极易为力。今果如孙君言，孙
君药俱在，急煎饮之。药用牡丹皮、桑白皮、白藓皮、木通、前胡、枳壳、桔梗、甘草、杏
仁、苡仁、葶苈子，服后大便里急后重者二十余次，所下黑紫脓血甚多，喘咳稍定，痰红稍
淡
。二三剂乃能伏枕而睡。改用白芍、当归、白藓皮、甘草、贝母、黄连、金银花、皂角子、
苡仁、麦冬、木通，连饮二帖，足上跟踝疮肿渐消，其夜阴囊出臭脓血二碗许。次早诊之，
两尺脉不洪大矣，仍用前剂加丹参又两帖。阴囊结靥甚浓，横裂一缝，三日后随缝连皮落下
约重五六两，浓可半寸，色如猪肝，洞见两阴子，系一光薄白胞，令人骇然，此也亘千古稀
见者。举家谓阴囊乃致命之所，且未有子，今烂去，即使复好，也不能育子矣。环哭甚悲。
予谕之曰∶此毒去也，而真元不伤，吾能使其生肉如故，也不妨于生育，毋过虑焉。举家
将信将
疑。予即用红粉霜加生肌末药敷上，一日三次，并不作痛，脓水立干。外以人参、当归、酒
炒白芍、白芷、甘草、白藓皮、皂角子、苡仁、何首乌调理一月，囊肌全生，诸症悉愈。
乃令日用土茯苓、猪肉各半斤同煮极烂，将肉入酱盐如常法食之，汤当茶饮，脱然全瘳。次
年生女。
朱怀竹正值壮年，因在外居住时行为不检点而染上梅毒（杨梅疮）。他害怕别人知道此事，又想尽快回家，于是请求医生让他迅速痊愈。每天使用药物进行外部熏蒸，但熏蒸后没有效果；又频繁用药水清洗，清洗后病情也未见好转；接着用散剂药物直接点涂患处，一天内还要服用三帖煎药。像这样持续了两个月，不仅疮疡无法治愈，毒邪反而被逼迫进入体内。
在下部，肛门脱出两寸多，周围疮疡密布如同菌菇状，无法回纳，导致因此不能行走和坐卧；在上部，毒邪侵入肺部，出现气喘咳嗽、气息上涌，胸膈部位胀闷不适，无法仰卧，内部发热而外部怕冷，睡眠和饮食都废弛停止，一闭上眼睛就会说胡话。阴囊处肿块红肿疼痛，双腿上的疮疡蔓延并肿大，精神恍惚不定，只能躺在软床上被人抬回家。他的弟弟朱少竹迎接我为其诊脉，六脉均呈现洪大且急促的脉象。
我对朱少竹说：“病情非常严重，幸好患者正值壮年，还可以治疗。现在我还不能给他敷药，要等到他胸中瘀血毒物排出之后才可以服药。否则，如果我的药物引起出血，反而会让他产生怀疑。可惜城中各位朋友很少有能识别这种病的，一旦误治，大事就完了。务必谨慎，务必谨慎！”朱少竹一向信任我，坚决请求我开药，但我没有给他服用。朱怀竹见我不开药，便延请张、程两位医生进行治疗。中午服下药物后，傍晚时分突然大发喘咳，吐出约一碗多的紫黑色血块，状如脓液，满屋腥臭难闻，令人无法靠近。
朱怀竹心中惊慌，朱少竹安慰他说：“不要害怕。孙先生早已预言，你胸中的胀闷是由于熏药逼迫毒邪入内，向上压迫肺部，痰浊与瘀血壅塞肺窍，即将化脓，所以出现气喘咳嗽不能平卧的症状。从脉象洪大而数也可以得知这一点，必须等待呕吐之后顺势消除病邪，这很容易见效。现在果然像孙先生说的那样，孙先生的药还在，赶快煎煮服用。”所用的药物包括牡丹皮、桑白皮、白藓皮、木通、前胡、枳壳、桔梗、甘草、杏仁、苡仁、葶苈子。服用后，患者大便出现里急后重的症状二十多次，排出的黑紫色脓血量很多，气喘咳嗽稍微平息，痰中带红的情况稍变淡。经过两三剂药的调理，才能伏枕入睡。
随后改用白芍、当归、白藓皮、甘草、贝母、黄连、金银花、皂角子、苡仁、麦冬、木通，连续服用两帖，脚跟上脚踝处的疮肿逐渐消退。当天夜里，阴囊流出约两碗多的臭脓血。第二天早晨诊脉，双尺脉不再洪大了，仍然使用前面的方剂加入丹参，再服两帖。阴囊处结痂非常厚，横向裂开一道缝隙，三天后随着裂缝，连皮带肉脱落，重量约有五六两，厚度可达半寸，颜色像猪肝一样，透过创面可以看到两个睾丸，包裹着一层光薄的白色胞膜，令人感到骇然，这是千古罕见的病例。全家都认为阴囊是致命的关键部位，而且他没有儿子，现在烂掉了，即使后来长好，也不能生育了。全家人围着痛哭，非常悲伤。
我劝慰他们说：“这是毒邪已去，而真元没有受损，我能让肌肉重新生长如初，不妨碍生育，不必过度忧虑。”全家人将信将疑。我立即用红粉霜配合生肌散敷在伤口上，每天三次，并不感到疼痛，脓水立刻干燥。外用由人参、当归、酒炒白芍、白芷、甘草、白藓皮、皂角子、苡仁、何首乌组成的方剂调理一个月，阴囊肌肤完全再生，所有症状全部痊愈。
于是嘱咐他每天取土茯苓和猪肉各半斤，一起煮至极烂，将肉按照常规方法加酱盐调味食用，汤汁当作茶水饮用，身体彻底康复，完全痊愈。第二年生了一个女儿。
Zhu Huaizhu was in the prime of life. Due to indiscreet behavior while staying away from home, he contracted syphilis (Yangmei Chuang). Fearing that others would find out and wishing to return home quickly, he sought a rapid cure. He used external fumigation daily, but it was ineffective; he frequently washed with medicinal water, but it did not heal; then he applied powdered medicine directly to the sores, and took three decoctions per day. For two months like this, not only did the sores fail to heal, but the toxin was driven inward.
In the lower part, the anus prolapsed by more than two cun, surrounded by sores dense as mushrooms, which could not be reduced, making walking and sitting impossible. In the upper part, the toxin entered the lungs, causing wheezing, coughing, and surging qi, with distension and stifling in the chest and diaphragm, preventing supine lying. There was internal heat and external aversion to cold, leading to the abandonment of sleep and diet; closing his eyes triggered delirious speech. The scrotum had nodules that were red, swollen, painful, and tender; sores on both legs spread and swelled. His spirit was confused, and he was carried home on a soft bed. His younger brother, Zhu Shaozhu, welcomed me to take his pulse. All six pulses were flooding (Hong), large, and rapid (Shu).
I told Shaozhu: "The disease is critical. Fortunately, he is young and strong, so it is still treatable. I cannot apply medication yet; wait until the stasis and toxins in his chest are expelled before administering oral medicine. Otherwise, if my medicine induces bleeding, it may cause him to doubt. Few friends in the city recognize this disease. A mistake would be disastrous. Be cautious, be cautious!" Shaozhu trusted me and insisted I prescribe medicine, but I refused. Seeing that I did not prescribe, Huaizhu invited Doctors Zhang and Cheng. At noon, after taking their medicine, at dusk he suddenly suffered severe wheezing and coughing, vomiting over a bowlful of purple-black blood clots resembling pus. The room was filled with a foul odor that was unbearable.
Huaizhu panicked. Shaozhu comforted him: "Do not fear. Dr. Sun predicted earlier that your chest distension was caused by fumigation forcing the toxin inward, pressing upon the lungs. Phlegm and blood stasis obstructed the lung orifices, leading to suppuration, hence the wheezing and inability to lie flat. This is confirmed by the flooding and rapid pulse. We must wait for the expulsion of these materials and then clear them, which will be easy. It has happened exactly as Dr. Sun said. His medicine is here; boil and drink it immediately." The prescription consisted of Mudanpi (Moutan Cortex), Sangbaipi (Mori Cortex), Baixianpi (Dictamni Cortex), Mutong (Akebiae Caulis), Qianhu (Peucedani Radix), Zhike (Aurantii Fructus), Jiegeng (Platycodonis Radix), Gancao (Glycyrrhizae Radix et Rhizoma), Xingren (Armeniacae Semen Amarum), Yiren (Coicis Semen), and Tinglizi (Lepidii Semen). After ingestion, he experienced tenesmus (Li Ji Hou Zhong) more than twenty times, passing large amounts of black-purple purulent blood. The wheezing and coughing subsided slightly, and the redness in the sputum faded somewhat. After two or three doses, he could finally rest his head on the pillow and sleep.
Subsequently, the formula was changed to Baishao (Paeoniae Radix Alba), Danggui (Angelicae Sinensis Radix), Baixianpi, Gancao, Beimu (Fritillariae Bulbus), Huanglian (Coptidis Rhizoma), Jinyinhua (Lonicerae Japonicae Flos), Zaojiaoziren (Gleditsiae Sinensis Semen), Yiren, Maidong (Ophiopogonis Radix), and Mutong. After two doses, the swelling of the sores on the heels and ankles gradually subsided. That night, approximately two bowls of foul-smelling purulent blood were discharged from the scrotum. The next morning, the pulses at both Chi positions were no longer flooding. The previous formula was continued with Danshen (Salviae Miltiorrhizae Radix et Rhizoma) added, for another two doses. Thick crusts formed on the scrotum, splitting horizontally. Three days later, the skin and flesh fell off along the crack, weighing about five to six liang, with a thickness of half a cun. The color resembled pig liver, revealing the two testes covered by a thin, white membrane. This was shocking and rare in history. The family believed the scrotum was vital and, having no sons, feared that even if healed, fertility would be lost. They wept bitterly around him.
I advised them: "The toxin is gone, and the True Yuan (Zhen Yuan) is undamaged. I can regenerate the flesh as before, without affecting fertility. Do not worry excessively." The family remained skeptical. I immediately applied Hongfenshuang (Red Powder Frost) mixed with a flesh-regenerating powder to the wound, three times a day. There was no pain, and the discharge dried up immediately. Externally, a regimen of Renshen (Ginseng Radix et Rhizoma), Danggui, Jiuchao Baishao (Wine-fried Paeoniae Radix Alba), Baizhi (Angelicae Dahuricae Radix), Gancao, Baixianpi, Zaojiaoziren, Yiren, and Heshouwu (Polygoni Multiflori Radix) was used for one month to regulate the body. The scrotal skin fully regenerated, and all symptoms resolved.
He was instructed to cook half a jin each of Tufuling (Smilacis Glabrae Rhizoma) and pork until very soft. The meat was seasoned with sauce and salt as usual, and the broth was drunk as tea. He recovered completely. The following year, a daughter was born.