治上热下寒。服凉药更甚等症。
即桂附地黄丸倍用桂附。加芍药元参各四两。
陈修园曰。此孙真人千金翼方也。芍药能敛木中之火气。以归其根。元参能启水中之精
气。以交于上。故加此二味于八味丸中。一以速附子之下行。一以防肉桂之上 。凡口舌等
疮。面红目赤。齿牙浮动。服凉药而更甚者。此为秘法。
治命门火衰。不能生土。吐利厥冷。有时阴火上冲。则头面赤热。眩晕恶心。浊气逆满。
则胸胁刺痛。脐肚胀急。
即四君子汤加山药黄 。（人参三两。用川附子一两五钱煮汁收入。去附子。○黄 一
两
五钱。用川芎一两酒煮收入。去川芎。○山药一两。用干姜三钱煎汁收入。去干姜。○白术
二两。用陈皮五钱煮汁收入。去陈皮。○茯苓二两。用肉桂六钱酒煮汁收入。去肉桂。○甘
草一两五钱。用乌药一两煮汁收入。去乌药。○上五味。除茯苓用文武火缓缓焙干。勿炒伤
药性为末。每服三钱。水一盏。姜三片红枣一枚。煎数沸。入益一捻和滓调服。服后饮热酒
一杯。以助药力。○按炼蜜为丸。每服三钱。更妙。
陈修园曰。此方出虞天益制药秘旨。颇有意义。张石顽医通之注解亦精。石顽云。方本
千金方一十三味。却取附子等辛燥之性。逐味分制。四君 薯之中。其力虽稍逊原方一筹。
然雄烈之味。既去真滓。无形生化有形。允为温补少火之驯剂。而无食气之虞。真千金之功
臣也。
治疗上热下寒，服用凉药后症状反而加重等病症。
即桂附地黄丸（由肉桂、附子、熟地黄、山茱萸、山药、泽泻、牡丹皮、茯苓组成的方剂）中加倍使用肉桂和附子，加入芍药、元参各四两。
陈修园说：此方出自孙思邈《千金翼方》。芍药能收敛肝木中的火气，使其回归本源；元参能激发肾水中的精气，使其上交于心。因此在这八味丸中加入这两味药，一味是为了加速附子的下行作用，一味是为了防止肉桂的上浮之性。凡是口舌生疮、面色红赤、眼睛发红、牙齿松动浮动，服用凉药后病情加重的，这是秘法。
治疗命门火衰（肾阳不足），不能温煦脾土，出现呕吐腹泻、四肢厥冷等症状；有时阴火上冲，导致头面部发热发红、头晕目眩、恶心；浊气逆乱充满胸胁，则胸胁刺痛，肚脐及腹部胀满急迫。
即四君子汤（由人参、白术、茯苓、甘草组成的补气基础方）加入山药、黄芪。具体炮制方法为：人参三两，用川附子一两五钱的煎煮汁液浸泡收汁，去掉附子；黄芪一两五钱，用川芎一两的酒煮汁液浸泡收汁，去掉川芎；山药一两，用干姜三钱的煎煮汁液浸泡收汁，去掉干姜；白术二两，用陈皮五钱的煎煮汁液浸泡收汁，去掉陈皮；茯苓二两，用肉桂六钱的酒煮汁液浸泡收汁，去掉肉桂；甘草一两五钱，用乌药一两的煎煮汁液浸泡收汁，去掉乌药。以上五味药，除了茯苓用文火武火交替缓缓焙干外，其余不要炒制以免损伤药性，然后研成细末。每次服用三钱，用水一盏，生姜三片，红枣一枚，煮沸数次，加入“益一捻”调和药渣调服。服药后喝一杯热酒，以助药力。按语：若炼蜜制成丸剂，每次服用三钱，效果更好。
陈修园说：此方出自虞天益的《制药秘旨》，颇有深意。张石顽在《医通》中的注解也很精辟。张石顽说：本方原本出自《千金方》十三味药，但采取将附子等辛燥性质的药物逐味分别炮制的办法。虽然四君子汤加山药、黄芪的力量稍逊于原方一筹，但是那些雄烈的气味既然去除了真正的杂质，无形之气转化为有形之质，确实是温和补益少火的驯良药剂，而没有耗伤正气的担忧，真是《千金方》的功臣啊。
Treats conditions of upper heat and lower cold, where taking cooling medicines exacerbates the symptoms.
This is Guizhi Fuzi Dihuang Wan (Cinnamon Twig and Aconite Rehmannia Pill), with doubled amounts of Rougui (Cortex Cinnamomi) and Fuzi (Radix Aconiti Lateralis Preparata), plus Shaoyao (Radix Paeoniae Alba) and Yuanshen (Radix Scrophulariae) each at four liang.
Chen Xiuyuan states: This formula originates from Sun Simiao's *Qianjin Yifang*. Shaoyao can restrain the fire qi within Wood (Liver), returning it to its root; Yuanshen can stimulate the essence qi within Water (Kidney), allowing it to ascend and interact with the Upper Jiao. Therefore, these two herbs are added to the Ba Wei Wan (Eight-Ingredient Rehmannia Pill). One serves to accelerate the downward movement of Fuzi, and the other prevents the upward floating of Rougui. For any sores in the mouth and tongue, red face, red eyes, loose teeth, or worsening symptoms upon taking cooling medicines, this is a secret method.
Treats Mingmen Fire Decline (Decline of Gate of Life Fire/Kidney Yang Deficiency), where the Fire cannot generate Earth (Spleen/Stomach), leading to vomiting, diarrhea, and cold extremities; sometimes Yin Fire surges upward, causing redness and heat in the head and face, dizziness, nausea; turbid Qi rebels and fills the chest and hypochondrium, causing stabbing pain in the chest and hypochondrium, and distension and urgency in the umbilical and abdominal regions.
This is Sijunzi Tang (Four Gentlemen Decoction) added with Shanyao (Rhizoma Dioscoreae) and Huangqi (Radix Astragali). The specific processing methods are as follows: Renshen (Radix Ginseng) three liang, soaked in the decoction juice of one chao five qian of Chuan Fuzi (Prepared Radix Aconiti Lateralis), then removing the Fuzi; Huangqi one chao five qian, soaked in the wine-decoction juice of one liang of Chuanxiong (Rhizoma Chuanxiong), then removing the Chuanxiong; Shanyao one liang, soaked in the decoction juice of three qian of Ganjiang (Rhizoma Zingiberis Recens), then removing the Ganjiang; Baizhu (Rhizoma Atractylodis Macrocephalae) two liang, soaked in the decoction juice of five qian of Chenpi (Pericarpium Citri Reticulatae), then removing the Chenpi; Fuling (Poria) two liang, soaked in the wine-decoction juice of six qian of Rougui (Cortex Cinnamomi), then removing the Rougui; Gancao (Radix Glycyrrhizae) one chao five qian, soaked in the decoction juice of one liang of Wuyao (Radix Linderae), then removing the Wuyao. Of the above five herbs, except for Fuling which is slowly dried over alternating mild and strong heat, do not stir-fry the others to avoid damaging their medicinal properties, then grind into fine powder. Take three qian per dose, with one zhan of water, three slices of Shengjiang (Rhizoma Zingiberis Recens), and one Hongzao (Fructus Jujubae), boil for several boils, add "Yi Yi Nian" (likely a typo or specific local term, possibly referring to a preparation aid or residue handling instruction, literally 'add one pinch') to mix with the dregs and take. After taking the medicine, drink a cup of hot wine to assist the medicinal power. Note: If processed into pills with refined honey, taking three qian per dose is even better.
Chen Xiuyuan states: This formula comes from Yu Tianyi's *Zhi Yao Mi Zhi* (Secret Instructions on Drug Processing) and has profound meaning. Zhang Shiweng's annotation in *Yi Tong* is also exquisite. Zhang Shiweng says: The original formula consists of thirteen ingredients from *Qianjin Fang*, but adopts the method of separately processing the acrid and dry nature of herbs like Fuzi. Although the strength of Sijunzi Tang plus Shanyao and Huangqi is slightly inferior to the original formula by one notch, since the fierce qualities have removed the true dregs, formless Qi transforms into formed substance, it is indeed a gentle agent for warming and tonifying the Minor Fire (Shao Huo) without the fear of consuming Qi. It is truly a meritorious minister of *Qianjin Fang*.