手厥阴心主之脉。起于胸中。出属心包。下膈。历络三焦（三焦为心包之维。故心包脉
历络
三焦之经也）。其支者。循胸出胁下腋三寸。上抵腋下。下循 内。行太阴少阴之间（太阴行
之前。少阴行 之后。而心主行其中也）。入肘中（曲泽穴分也）。下臂行两筋之间（两筋之
间。间使所居）。入掌中（劳宫所在也）。循中指出其端（中冲在此中指之端）。其支者别掌中
循小指次指。出其端（手心主。自此交入手少阳）。是动则病（手厥阴常多血少气。今气先病
是谓是动也）。手心中热。肘臂挛急（肘臂变急。盖谓屈而不伸也）。腋肿。甚则胸胁支满
心中澹澹（席延经云。澹澹水摇也）。大动。面赤目黄。喜笑不休。是主脉所生病者（血受
病于气。是气之所生。故云。所生病也）。烦心。心痛。掌中热。若盛者。寸口大一倍于人
迎。虚者寸口反小于人迎也。
手心主之别。名曰内关。去腕二寸。出于两筋之间。循经以上。系于心包络。心系实。
则心痛。虚则为烦。取之两筋间也。
手心主之筋。起于中指。与太阴之筋。并行结于肘内廉。上臂阴结腋下。下散前后挟胁
其
支者。入腋散胸中。结于贲。其病当所过者。支转筋。前及胸痛。息闭。治在燔针劫刺。以
知为数。以痛为输。名曰孟冬痹也。
手厥阴心包脉。从腹走手。长三尺五寸。左右共七尺。凡一十八穴。
天池二穴。天泉二穴。曲泽二穴。 门二穴。间使二穴。中冲二穴。内关二穴。劳宫二
穴。太陵二穴。
手厥阴心包经的经脉，起始于胸中，出来归属于心包络，向下穿过膈肌，依次联络上、中、下三焦（三焦是心包的外围护卫，所以心包经的脉气经过联络三焦的经络）。它的分支，沿着胸部出于胁部，在腋下三寸处上行至腋下，向下沿手臂内侧运行，走在手太阴肺经和手少阴心经之间（手太阴肺经行在前，手少阴心经行在后，而手厥阴心包经行在中间）。进入肘窝中（即曲泽穴所在部位），下行前臂，行于两根肌腱之间（两筋之间，是间使穴所在的位置），进入手掌心中（劳宫穴所在之处），沿中指直达其末端（中冲穴位于中指指尖）。另一分支从掌中分出，循行至食指与无名指之间，出于其末端（手心主经由此交接入手少阳三焦经）。
当本经发生异常变动时就会发病（手厥阴经通常多血少气，现在气先发病，这称为“是动病”）。症状表现为手心发热，肘臂拘挛紧急（肘臂变得拘急，大概是指弯曲而不能伸直），腋窝肿胀，严重时胸胁支撑胀满，心中悸动不安（《席延经》说：澹澹形容水摇动的样子，此处指心跳剧烈如水面波动），面色发红，眼睛发黄，喜欢笑个不停。
凡是本经经脉气血失调所生的疾病（血液受气的影响而生病，这是气所产生的病变，所以称为“所生病”）。症状包括心烦、心痛、手掌心发热。如果邪气盛实，人迎脉搏动比寸口大一倍；如果是正气虚弱，寸口脉搏动反而小于人迎。
手厥阴心包经的别络，名叫内关，距离腕横纹二寸，出于两筋之间，沿经脉向上，联系于心包络。心系实证，则出现心痛；心系虚证，则出现心烦。治疗时取两筋之间的穴位。
手厥阴心包经的筋，起始于中指，与手太阴肺经的筋并行，结聚于肘关节内侧，沿上臂内侧上行结聚于腋下，向下散布于前后两侧夹持胁肋。它的分支，进入腋部散布于胸中，结聚于贲门。该经筋病变时，在其循行经过的部位会出现支撑感、转筋（肌肉痉挛）、向前牵引胸痛、呼吸闭塞。治疗采用燔针劫刺法（烧红的针快速刺入），以病情好转为度，以疼痛点作为腧穴。这种病被称为孟冬痹。
手厥阴心包经的脉气，从腹部走向手部，全长三尺五寸，左右两侧共七尺。共有十八个穴位。
天池穴二穴，天泉穴二穴，曲泽穴二穴，郄门穴二穴，间使穴二穴，中冲穴二穴，内关穴二穴，劳宫穴二穴，太陵穴二穴。
The meridian of Hand-Jueyin Pericardium originates in the chest, emerges to connect with the Pericardium (Pericardium, the protective sac of the heart), descends through the diaphragm, and successively connects with the Sanjiao (Triple Burner, a concept referring to three functional systems in the body). Its branch follows the chest, emerges from the hypochondrium, ascends to the axilla at three cun lateral to the nipple, then descends along the medial aspect of the arm, running between the Lung Meridian of Hand-Taiyin and the Heart Meridian of Hand-Shaoyin. It enters the cubital fossa (at Quze PC3), descends along the forearm between two tendons (where Neiguan PC6 is located), enters the center of the palm (Laogong PC8), and follows the middle finger to its tip (Zhongchong PC9). Another branch separates from the palm, runs between the index and ring fingers, and emerges at their tips (here the Pericardium Meridian connects with the Triple Burner Meridian of Hand-Shaoyang).
When the meridian undergoes pathological changes ("Shi Dong" diseases), symptoms include heat in the palms, spasticity and stiffness of the elbow and arm (difficulty extending the limbs), swelling of the axilla, and in severe cases, distension and fullness in the chest and hypochondrium, palpitations (described as "dandan," resembling water rippling), redness of the face, yellowing of the eyes, and excessive laughter.
Diseases generated by the meridian itself ("Suo Sheng Bing") involve vexation, heart pain, and heat in the palms. In excess conditions, the Renying pulse (ST9) is larger than the Cunkou pulse (Radial artery) by one fold; in deficiency conditions, the Cunkou pulse is smaller than the Renying pulse.
The Luo-connecting vessel of the Hand-Jueyin Pericardium is named Neiguan (PC6), located two cun proximal to the wrist crease, emerging between the two tendons, ascending along the meridian to connect with the Pericardium. Excess in the Heart system causes heart pain; deficiency causes vexation. Treatment involves needling the point between the two tendons.
The sinews of the Hand-Jueyin Pericardium originate at the middle finger, run parallel with the sinews of the Lung Meridian of Hand-Taiyin, and knot at the medial aspect of the elbow. They ascend along the medial arm to knot in the axilla, then descend to scatter anteriorly and posteriorly flanking the costal region. A branch enters the axilla, scatters in the chest, and knots at the贲 (cardia/upper stomach). Pathological changes occur at the sites traversed, manifesting as support-like sensations, spasms, anterior chest pain, and dyspnea. Treatment utilizes burning needle puncture (fire needle therapy), using the number of applications until improvement is felt, and using painful points as acupoints. This condition is called "Mengdong Bi" (early winter bi syndrome).
The meridian of Hand-Jueyin Pericardium travels from the abdomen to the hand, measuring three chi and five cun in length, totaling seven chi for both sides. There are eighteen acupoints in total: Tianchi (PC1) x2, Tianquan (PC2) x2, Quze (PC3) x2, Ximen (PC4) x2, Jianshi (PC5) x2, Zhongchong (PC9) x2, Neiguan (PC6) x2, Laogong (PC8) x2, and Tailing (PC7) x2.