辛热，有毒。久服令人筋挛。 法以黄泥包，炭火烧一日一夕，乃可用之。恶羊
血，不入汤液。
《本经》主寒热鼠 蚀，死肌风痹，腹中坚癖邪气。
发明 时珍云∶ 石与砒石相近，性亦相类。但砒石略带黄晕， 石全白，稍有分辨。
而古方 石与矾石常相浑书，二字相似故误耳。然矾石性寒无毒， 石性热有毒，不可不审
。《甄权》除膈间积气、冷湿风痹，瘙痒积十年者。仲景云∶生用破人心肝。严冬以此置水
中则水不冰，其热毒之性不减砒石。今药肆中往往以充砒石，而 石仅可破积攻痹，不能开
痰散结，是以胜金丹、截疟丹服之不效者，良由误用 石之故。按王子敬《静息帖》言，
石深是可疑，凡喜服寒食散者，辄发痈毒，故云深可疑也。以其毒烈干汞最速，故《丹方》
目为仙药，凡山中有 则春不生草，冬不积雪，而鼠食则毙，蚕食则肥，物类之宜忌，有不
可解者。其特生 石有苍白、紫桃花色、金星、银星等类，其毒不异。惟出金穴中者，名握
雪石，虽温无毒，与上迥然不同。
出信州，故又名信石
苦辛大热，大毒。色白有黄晕者名金脚砒；炼过者曰砒
霜。
色红者最劣，不堪入药。畏绿豆芽、茶、冷水，入药醋煮用，或与芽茶同用，或与浸湿
生绿
豆仁同研，以杀其毒。中其毒者，以生羊血解之，冷水多灌亦解，若犯火酒，必不可救。
发明 砒霜疟家常用，入口则吐利兼作。吐后大渴，则与绿豆汤饮之。砒性大毒，
误食
必死。奈何以必死之药，治必不死之病，岂不殆哉。然狂痴之病，又所必需，胜金丹用之，
无不应者。枯痔散与天灵盖同用，七日痔枯自落，取热毒之性，以枯歹肉，天灵盖以透骨髓
，散宿垢，长肌肉也。
辛，热，有毒。长期服用会导致筋脉拘挛。炮制方法是用黄泥包裹，在炭火中烧一天一夜，之后才可以使用。忌与羊血同用，不用于汤剂。
《神农本草经》记载：主治寒热、鼠瘘（淋巴结核）、死肌、风痹，以及腹中的坚硬积块和邪气。
【发明】李时珍说：石（砒石的一种）与砒石相近，药性也相似。但砒石略带黄色晕圈，石全白，稍有区别。然而古方中石与矾石常常混淆书写，是因为这两个字字形相似而造成的错误。但是矾石性寒无毒，石性热有毒，不可不仔细辨别。《雷公炮炙论》记载：能消除膈间积气、冷湿风痹，以及持续十年的瘙痒。张仲景说：生用会损伤人心肝。严冬时节将其放入水中，水也不会结冰，其热毒之性不减于砒石。如今药店中往往用它来冒充砒石，而石仅能破除积滞、攻逐痹痛，不能化痰散结，所以服用胜金丹、截疟丹无效的原因，很大程度上是由于误用了石。据王子敬《静息帖》所言，石深（指石毒性深重）是可疑的，凡是喜欢服用寒食散的人，往往会引发痈毒，所以说它深可疑。因为它毒性猛烈，干汞（一种炼丹原料）的速度最快，所以《丹房须知》将其列为仙药。凡是有石的山中，春天不长草，冬天不积雪，老鼠吃了就会死亡，蚕吃了就会肥胖，物类的适宜与禁忌，有无法解释的地方。其中特别产出的石有苍白、紫桃花色、金星、银星等类别，其毒性没有不同。只有出自金穴中的，名叫握雪石，虽然温和无毒，与上述种类截然不同。
产于信州，所以又名信石。
苦，辛，大热，大毒。颜色白带有黄色晕圈的叫做金脚砒；经过炼制后称为砒霜。
颜色红的品质最差，不堪入药。畏绿豆芽、茶、冷水，入药时用醋煮，或者与芽茶同用，或者与浸湿的生绿豆仁同研，以减轻其毒性。中毒者，用生羊血解毒，大量灌服冷水也能解毒，如果误服火酒（烈性酒），则必定无法救治。
【发明】砒霜是疟疾患者常用的药物，入口后呕吐和腹泻同时发作。吐完后极度口渴，则给予绿豆汤饮用。砒性大毒，误食必死。为何要用必死的药物去治疗必不死之病，岂不是太危险了吗？然而对于狂痴之病，又是必需的。胜金丹中使用它，没有不应验的。枯痔散与天灵盖同用，七天后痔疮干枯自然脱落，是利用其热毒之性来使坏肉枯萎，天灵盖用来透达骨髓，消散宿垢，促进肌肉生长。
Pungent, hot, toxic. Long-term use causes tendon contraction. The processing method involves wrapping it in yellow clay and firing it in charcoal fire for one day and one night before it can be used. It is incompatible with sheep blood and is not used in decoctions.
The *Shennong Bencao Jing* (Divine Farmer's Materia Medica) states: It treats chills and fever, scrofula (lymphatic tuberculosis), necrotic tissue, wind-bi syndrome, as well as hard masses and pathogenic factors in the abdomen.
[Invention] Li Shizhen said: Shi (a type of arsenic stone) is similar to Pi Shi (Arsenic Stone), and their properties are also similar. However, Pi Shi has a slight yellow halo, while Shi is entirely white, allowing for some distinction. Nevertheless, in ancient prescriptions, Shi and Fan Shi (Alum Stone) were often confused due to the similarity of their characters. However, Fan Shi is cold in nature and non-toxic, whereas Shi is hot in nature and toxic; this must not be overlooked. *Leigong Paozhi Lun* records that it eliminates accumulated qi in the diaphragm, cold-damp wind-bi, and itching lasting for ten years. Zhang Zhongjing stated: When used raw, it damages the heart and liver. In severe winter, when placed in water, the water does not freeze, indicating its hot and toxic nature is no less than that of Pi Shi. Nowadays, pharmacies often use it to substitute for Pi Shi, but Shi can only break down accumulations and attack bi-syndromes; it cannot resolve phlegm and dissipate nodules. Therefore, the ineffectiveness of Shengjin Dan (Golden Victory Pill) and Jienue Dan (Malaria-Cutting Pill) is largely due to the mistaken use of Shi. According to Wang Zijing's "Jingxi Tie," the depth of toxicity of Shi is suspicious. Those who enjoy taking Hanshi San (Cold Food Powder) often develop carbuncles and sores, hence it is considered highly suspicious. Its toxicity is fierce, acting on mercury faster than any other substance, thus it is listed as an immortal medicine in *Danfang*. In mountains where Shi exists, grass does not grow in spring, and snow does not accumulate in winter. Mice die after eating it, while silkworms become fat after consuming it. The suitability and taboos of these creatures are inexplicable. Specifically produced Shi comes in varieties such as pale white, purple-peach-blossom color, gold stars, and silver stars, all with similar toxicity. Only that found in gold veins, named Woxue Shi (Snow-Holding Stone), is warm and non-toxic, distinctly different from the aforementioned types.
It originates from Xinzhou, hence also known as Xinshi.
Bitter, pungent, extremely hot, highly toxic. Those with a white color and yellow halo are called Jinjiao Pi (Gold-Footed Arsenic); those refined are called Pisuang (Arsenic Frost).
Those with red color are of the poorest quality and unsuitable for medicinal use. It is feared by mung bean sprouts, tea, and cold water. For medicinal use, it is boiled with vinegar, or used together with bud tea, or ground with soaked raw mung beans to mitigate its toxicity. For poisoning, fresh sheep blood can detoxify it, and copious amounts of cold water can also resolve it. If strong liquor is ingested, it is incurable.
[Invention] Pisuang is commonly used by malaria patients; upon ingestion, vomiting and diarrhea occur simultaneously. After vomiting, if extreme thirst occurs, mung bean soup should be given. Pisuang is highly toxic; accidental ingestion leads to death. Why use a potentially fatal drug to treat a disease that is not necessarily fatal? Is this not dangerous? However, for manic and delirious diseases, it is essential. When used in Shengjin Dan, it is invariably effective. When used in Kuzhi San (Hemorrhoid-Withering Powder) combined with Tianlinggai (Skull Cap), the hemorrhoids wither and fall off naturally after seven days. This utilizes the hot and toxic nature of Pisuang to wither bad flesh, while Tianlinggai penetrates the bone marrow, disperses old filth, and promotes muscle growth.