〔时珍曰〕用砒石二两，木鳖子仁、巴豆仁各半两， 砂二钱，为末，用木鳖子油、石
脑油和成一块，油裹，埋土坑内，四十九日取出，劈作小块，瓷器收用。
〔时珍曰〕用大坩埚一个，以礞石四两打碎，入硝石四两拌匀。炭火十五斤簇定， 至
硝尽，其石色如金为度。取出研末，水飞去硝毒，晒干用。
〔时珍曰〕凡入丸散，以罐固济，顶火 过，出火毒，研细水飞晒干用。
〔时珍曰〕凡盐，人多以矾、硝、灰、石之类杂之。入药须以水化，澄去脚滓，煎炼白
色，乃良。
〔 曰〕凡使，须用生姜自然汁煮干研粉用。每十两，用生姜一镒也。
〔时珍曰〕制法∶用白净朴硝十斤，长流水一石，煎化去滓，星月下露一夜，去水取硝
每
再露一夜取出。以大沙罐一个，筑实盛之，盐泥固济浓半寸，不盖口，置炉中，以炭火十斤，
从文至武 之。待沸定，以瓦一片盖口，仍前固济，再以十五斤顶火 之。放冷一伏时，取
出，隔纸安地上，盆覆三日出火毒，研末。每一斤，入生甘草
瓶收用。
〔李时珍说〕取砒石二两，木鳖子仁、巴豆仁各半两，砂二钱，研成粉末。用木鳖子油、石脑油和匀成一块，用油纸包裹，埋入土坑内，四十九天后取出，劈成小块，用瓷器收藏备用。
〔李时珍说〕取一个大坩埚，将礞石四两打碎，加入硝石四两拌匀。用十五斤炭火紧密围住加热，直到硝石完全烧尽，石头颜色变成金色为止。取出后研成粉末，用水漂洗以去除硝石的毒性，晒干后使用。
〔李时珍说〕凡是用于丸药或散剂，需用罐子密封固济，在顶部用火煅烧，以去除火毒，研细后水飞、晒干使用。
〔陈藏器说〕入药时需烧至通红，去掉粗糙部分后再使用。
〔陈藏器说〕入药时需烧至通红，用醋淬炼三到四次，研成粉末后水飞使用。
〔李时珍说〕凡是用盐，人们常以明矾、硝石、草木灰、石块等杂质掺杂其中。入药时必须用水溶解，澄清后去掉底部的沉淀物，煎炼成白色，才是好盐。
〔佚名作者说〕凡是要使用的，必须用生姜自然汁煮干后研粉使用。每十两药材，需用生姜一镒（约十二两）。
〔李时珍说〕制法：取白净朴硝十斤，长流水一石，煎化后去掉沉淀物，在星月之夜露天放置一夜，去掉水分取得硝石；再露天放置一夜后取出。取一个大沙罐一个，装实盛满，用浓盐泥封口加固半寸厚，不盖盖子，放在炉中，用十斤炭火，从文火逐渐转为武火煅烧。待沸腾稳定后，用一片瓦片盖住罐口，再次用盐泥加固，再用十五斤炭火在顶部煅烧。冷却一个时辰后取出，隔纸安放在地上，用盆覆盖三天以去除火毒，研成粉末。每一斤硝石，加入生甘草，装入瓶中收藏使用。
〔陈藏器说〕真硝石，用柳枝汤煎煮三个时辰，如果汤水变少，就添加热水，伏火即停止。〔佚名作者说〕凡是要使用硝石，在火中煅烧七十次。〔佚名作者说〕
〔雷斅说〕凡是要使用，必须水飞，去掉灰尘污秽，放入瓷器中，隔水炖煮至干，就能消除其毒性。〔李时珍说〕现在的人多用水飞洗净，醋煮干如霜状，刮下来使用。
[Li Shizhen said] Take 2 liang of arsenolite (Pishi), half a liang each of Semen Momordicae (Mubiezi Ren) and Semen Crotonis (Badou Ren), and 2 qian of realgar (Shashi), grind them into powder. Mix with oil from Semen Momordicae (Mubiezi You) and petroleum ether (Shinao You) to form a solid mass, wrap it in oiled paper, bury it in a soil pit for 49 days, then take it out, break it into small pieces, and store it in porcelain vessels for use.
[Li Shizhen said] Take one large crucible, crush 4 liang of Qingmoshi (Lengshi/Melanterite), mix it evenly with 4 liang of Nuxitrum (Xiaoshi). Surround it tightly with 15 jin of charcoal fire and heat until the Nuxitrum is completely burnt out and the stone turns golden in color. Take it out, grind it into powder, wash away the toxicity of Nuxitrum with water, dry it, and use it.
[Li Shizhen said] Whenever used in pills or powders, seal the container tightly with clay, roast over top fire to remove "fire toxicity," grind finely, perform wet grinding (shuifei), and dry before use.
[Chen Cangqi said] When used in medicine, burn until red-hot, remove the coarse parts, and then use.
[Chen Cangqi said] When used in medicine, burn until red-hot, quench in vinegar three or four times, grind into powder, and use after wet grinding (shuifei).
[Li Shizhen said] Regarding salt, people often adulterate it with alum (Fan), Nuxitrum (Xiao), ash, stones, etc. For medicinal use, it must be dissolved in water, clarified to remove sediment, and boiled until white, which indicates good quality.
[Anonymous author said] When preparing, it must be boiled dry in fresh ginger juice and then ground into powder. For every 10 liang of material, use 1 yi (approx. 12 liang) of fresh ginger.
[Li Shizhen said] Preparation method: Take 10 jin of pure Puxiao (Mirabilite/Puerariae Radix? Context implies Mirabilite/Natrii Sulfas based on context of purification), dissolve in 1 shi of running water, filter out impurities, and expose overnight under stars and moon. Remove water to obtain the crystal; expose again overnight, then take out. Place in a large sand jar, pack it firmly, seal the mouth with thick salt mud half an inch thick without covering the lid, place in a furnace, and use 10 jin of charcoal fire, starting from gentle fire (Wenhuo) to strong fire (Wuhuo). Once boiling stabilizes, cover the mouth with a tile, re-seal with mud, and roast with 15 jin of charcoal fire from above. Let it cool for one fu period (approx. 2 hours), take out, place on the ground through paper, cover with a basin for three days to remove "fire toxicity," grind into powder. For every 1 jin, add raw Gancao (Licorice Root), and store in bottles.
[Chen Cangqi said] True Xiaoshi (Nuxitrum), decoct in willow branch soup for three shichen (6 hours); if the liquid reduces, add hot water; stop when the "fire is subdued." [Anonymous author said] When using Xiaoshi, roast in fire seventy times. [Anonymous author said]
[Lei Xiao said] Whenever used, it must be wet-ground (shuifei) to remove dust and impurities, placed in porcelain vessels, and boiled dry in a double boiler to reduce its toxicity. [Li Shizhen said] Nowadays, people mostly clean it by wet grinding, boil it dry with vinegar until frost-like, scrape it off, and use it.