陈远公曰∶有大腿边旁长强穴间忽疼痛高肿，变成痈疽，久则肉中生骨，以铁
箝取出，已而又生，人以为多骨痈也，谁知是湿热毒所化乎！夫多骨痈之生，因人
多食瓜果，湿热所成者也，早治，一二剂便可解散，无如因循失治，以至湿壅添热，
热盛而化骨，日久迁延，卧床不能起也。说者谓初起时未尝有骨，可以内散，既生骨
后，必须烂骨，外取未可全恃，解散谁知不然，盖多骨证无形所化，非肉中真生骨
也，似骨而非骨耳。真骨难化，似骨又何难化之有，治法利湿清热，而主之补气血
之药，骨自消矣。五神汤∶茯苓一两，金银花三两，牛膝五钱，紫花地丁一两，车
前子一两。水煎服。二剂轻，三剂骨消，四剂疮口平，五剂痊愈。此以车前、茯苓利
水，地丁清热，牛膝、银花补中散毒，安得不奏功哉。（《冰鉴》）
王肯堂曰∶多骨疽，又名曰剩骨，又
名朽骨。生足胫上，生疽既溃甚久而不愈，腐烂出骨者是。盖因毒瓦斯壅盛，结成此骨，
非正骨也。此疽因未溃之前，补剂太过，故结毒而不散也。（《准绳》）
岐天师曰∶多骨疽，乃生于大腿之中，多生一骨者是，乃湿热而生者也，治之得
法，则易易耳。否则变生可畏，治以化骨至神丹即愈。苟或失治，即长一骨，横插
于皮间作痛，必须取出此骨始愈，以铁铗钳出之，外以生肌膏贴之。此方妙在用白
芍，盖白芍能平肝木，又能活筋。多骨疽者非骨也，筋变为骨，似骨而非骨也。白
芍不特平肝木之火，兼能散肝木之邪，邪去则筋舒，筋舒则似骨非骨者尽化，又加
金银花，原能去毒，此二味之所以相济也。（《秘录》）
雷真君曰∶大凡毒生环跳之穴，即多骨疽也。
张仲景曰∶多骨之生也，虽生于湿热，而成之不由湿热也。必平时喜饮凉水，好
食果品而成之，初起宜消毒散敷之。
陈实功曰∶多骨疽者，由疮溃后久不收口，乃气血不能营运至此，骨无荣养所
致，细骨由毒瓦斯结聚化成，大骨由受胎时精血交错而结，日后必成此疽也。但肾主
骨，宜服肾气丸、十全大补汤，先补脾肾，次用艾附饼灸之，令温暖腐毒，朽骨自然
脱尽，生肌敛口而愈。（《正宗》）
汪省之曰∶多骨疽，患一二年不愈，常落出骨一片，或细骨或有蛀蚀眼，或三五
个月，落骨一片，此骨非营气不从而生，乃母受孕复感精气而成。（《理例》）
《心法》曰∶多骨疽毋论老小，皆有生者，多在腮 、牙床、眼胞、颏下、手足、
腿膊等处。有因肾虚之人，生疮久硬不消，口不收敛，外被寒邪袭入，与脓毒凝结于
中，借人之气血化成多骨者。又有初生落草，肌肉之中按之如有脆骨，由胎元受之，
精血交错而致。迨其人长大后，必于脆骨之处，突然发肿而生疽，及溃后多骨脱出，
其口方收。亦有多骨出之不休者，名曰骨胀，难愈。以上二因，治法皆同，俱用隔
附子并艾灸之，以宣寒凝，令骨速脱。盖骨属肾，遇寒则凝，故从热治也。
陈远公说：在大腿旁边长强穴之间，忽然疼痛并高肿，变成痈疽，时间久了肉中生出骨头，用铁钳取出后，过段时间又会长出，人们认为这是多骨痈，谁知道这是湿热毒邪所化呢！多骨痈的产生，是因为人多吃瓜果，导致湿热蕴结所致。早期治疗，一二剂药便可消散解除；如果因循守旧、延误治疗，致使湿气壅滞增添热势，热盛而化生骨头，日久拖延，导致卧床不能起身。有人说初起时并没有骨头，可以内服消散；既然已经生出骨头后，必须使骨头腐烂，从外部取出，不能完全依赖内服消散。这种说法不对。大概多骨证是由无形之邪所化，并非肉中真正生出骨头，只是像骨头而不是真骨头罢了。真正的骨头难以化解，像骨头的东西又有什么难化解的呢？治疗方法是利湿清热，并辅以补益气血的药物，骨头自然就会消除。五神汤：茯苓一两，金银花三两，牛膝五钱，紫花地丁一两，车前子一两。水煎服。服用两剂症状减轻，三剂骨头消除，四剂疮口平整，五剂痊愈。这里用车前子、茯苓利水，地丁清热，牛膝、金银花补中散毒，怎么能不奏效呢。（《冰鉴》）
王肯堂说：多骨疽，又名剩骨，又名朽骨。生长在足胫部位，生疽溃烂很久不愈合，腐烂流出骨头的是。这是因为毒气壅盛，结成这种骨头，不是正常的骨头。这个疽因为在未溃烂之前，补益药物太过，所以结聚毒邪而不能消散。（《准绳》）
岐天师说：多骨疽，是生长在大腿中间，多长出一块骨头的是，这是由湿热产生的，治疗得当，就非常容易。否则变化产生令人畏惧的后果，使用化骨至神丹即可痊愈。如果失治，就会长出一根骨头，横向插入皮间引起疼痛，必须取出这根骨头才能痊愈，用铁夹钳出它，外部用生肌膏贴敷。这个方子的妙处在于使用白芍，因为白芍能平抑肝木，又能活血舒筋。多骨疽中的“骨”不是真骨，是筋变成了骨头，像骨头而不是真骨头。白芍不仅平抑肝木之火，还能疏散肝木之邪，邪气去除则筋脉舒展，筋脉舒展则那些似骨非骨的东西全部化解，再加上金银花，原本就能去毒，这两味药之所以相辅相成。（《秘录》）
张仲景说：多骨的产生，虽然生于湿热，但形成的原因并不完全由湿热决定。一定是平时喜欢喝凉水，喜好食用水果而形成的，初起适宜用消毒散外敷。
陈实功说：多骨疽，是由于疮疡溃烂后长久不收口，是气血不能运行至此，骨头缺乏荣养所致，细骨由毒气结聚化成，大骨由受胎时精血交错凝结而成，日后必然形成这个疽。但是肾主骨，适宜服用肾气丸、十全大补汤，先补益脾肾，其次用艾附饼灸法，令其温暖腐毒，朽骨自然脱落干净，生肌敛口而痊愈。（《正宗》）
汪省之说：多骨疽，患病一两年不愈合，经常掉落一片骨头，或是细骨或有蛀蚀孔眼，或者三五个月，掉落一片骨头，这块骨头不是因为营气不顺而生，而是母亲受孕时感受精气而成。（《理例》）
《医宗金鉴·心法要诀》说：多骨疽不论老少，都有发生的，多在腮部、牙床、眼睑、下巴下、手足、手臂、腿部等处。有因为肾虚的人，生疮长久坚硬不消，口部不收敛，外部被寒邪侵入，与脓毒凝结在中间，借人的气血化成多骨的。又有刚出生落草时，肌肉之中按压如有脆骨，由胎元遗传，精血交错导致。等到这个人长大后，必定在脆骨之处，突然发肿而生疽，及溃烂后多骨脱出，疮口才收敛。也有多骨排出不止的，名叫骨胀，难以痊愈。以上两种病因，治疗方法都相同，都用隔附子灸和艾灸的方法，以宣通寒凝，令骨头快速脱落。因为骨属肾，遇寒则凝滞，所以从热证来治疗。
Chen Yuan Gong said: Between the Changqiang acupoint (Changqiang, GV1) on the side of the thigh, there is sudden pain and high swelling, turning into a carbuncle or ulcer (Yong Ju). Over time, bone-like structures grow within the flesh. When extracted with iron forceps, they regenerate later. People consider this to be Duogu Carbuncle (Duogu Yong), but who knows it is transformed from damp-heat toxicity? The generation of Duogu Carbuncle arises because people consume too many melons and fruits, resulting in damp-heat accumulation. If treated early, one or two doses can resolve it. However, if treatment is delayed due to procrastination, dampness stagnates and adds heat; excessive heat transforms into bone. Prolonged illness leads to bedridden immobility. Some say that initially, no bone exists, so internal resolution is possible; once bone forms, it must rot for external extraction, and internal resolution alone is insufficient. This view is incorrect. Essentially, the "bone" in Duogu syndrome is formed by formless pathogens, not true bone growing in the flesh; it resembles bone but is not true bone. True bone is difficult to dissolve, so how could something resembling bone be difficult? The treatment method involves promoting diuresis to clear dampness and clearing heat, combined with herbs that tonify Qi and Blood. The bone will naturally dissipate. Wushen Tang (Five Gods Decoction): Fu Ling (Poria) 1 liang, Jin Yin Hua (Lonicerae Japonicae Flos) 3 liang, Niu Xi (Achyranthis Bidentatae Radix) 5 qian, Zi Hua Di Ding (Viola Yedoensis Herba) 1 liang, Che Qian Zi (Plantaginis Semen) 1 liang. Decoct in water and take orally. After two doses, symptoms lighten; after three doses, the bone dissolves; after four doses, the wound flattens; after five doses, recovery is complete. Here, Che Qian Zi and Fu Ling promote urination; Zi Hua Di Ding clears heat; Niu Xi and Jin Yin Hua tonify the middle and scatter toxicity. How could this fail to achieve efficacy? (From *Bing Jian*)
Wang Kentang said: Duogu Ju (Duogu Ulcer), also known as Sheng Gu (Remaining Bone) or Xiu Gu (Rotten Bone), occurs on the lower leg. It refers to an ulcer that has ulcerated and failed to heal for a long time, eventually rotting and expelling bone. This is caused by excessive accumulation of toxic qi, which condenses into this bone structure, which is not normal bone. This ulcer occurs because excessive tonifying agents were used before ulceration, causing the toxin to condense rather than disperse. (From *Zhun Sheng*)
Qi Tian Shi said: Duogu Ju grows in the middle of the thigh, characterized by the growth of an extra piece of bone, generated by damp-heat. If treated correctly, it is easy to cure. Otherwise, terrifying complications may arise. Treatment with Huagu Zhishen Dan (Bone-Dissolving Divine Elixir) leads to recovery. If neglected, a bone may grow and insert horizontally between the skin, causing pain; it must be removed with iron forceps for healing, followed by application of Shengji Gao (Flesh-Regenerating Ointment). The brilliance of this formula lies in the use of Bai Shao (Paeoniae Radix Alba), which soothes the Liver and activates tendons. The "bone" in Duogu Ju is not true bone; it is tendon transformed into bone, resembling bone but not being true bone. Bai Shao not only pacifies Liver Fire but also disperses Liver pathogenic factors. Once the pathogen is expelled, the tendons relax; when tendons relax, the bone-like structures dissolve. Added with Jin Yin Hua, which removes toxicity, these two ingredients complement each other perfectly. (From *Mi Lu*)
Lei Zhen Jun said: Generally, when toxicity arises at the Huantiao acupoint (Huantiao, GB30), it is Duogu Ju.
Zhang Zhong Jing said: The generation of bone-like structures, although arising from damp-heat, is not solely formed by damp-heat. It results from a habit of drinking cold water and consuming fruits. Initially, Xiaodu San (Toxin-Dispersing Powder) should be applied externally.
Chen Shigong said: Duogu Ju occurs when a sore fails to close after ulceration because Qi and Blood cannot circulate to the area, leaving the bone without nourishment. Fine bones are formed by the condensation of toxic qi, while large bones result from the intermingling of essence and blood during conception, leading to this ulcer later in life. Since the Kidney governs bone, it is appropriate to administer Shenqi Wan (Kidney Qi Pill) and Shiquan Dabu Tang (Decoction for Tonifying All Deficiencies). First, tonify the Spleen and Kidney; then apply Ai Fu Bing Moxibustion (Moxibustion with Mugwort and Asarum Cake) to warm the area and rot out the toxicity. The rotten bone will naturally fall off completely, allowing new flesh to grow and the wound to close. (From *Zheng Zong*)
Wang Sheng Zhi said: In Duogu Ju, if the condition persists for one or two years without healing, pieces of bone, either fine or with carious holes, may fall out every three to five months. This bone does not arise from the failure of Ying Qi (Nutritive Qi) to follow its course, but is formed by the reception of essence and qi during maternal conception. (From *Li Li*)
*Xin Fa* states: Duogu Ju can occur in people of any age, commonly appearing on the cheeks, gums, eyelids, chin, hands, feet, arms, and legs. In individuals with Kidney deficiency, sores may remain hard and unhealed for a long time without closing. External cold pathogens invade and condense with pus and toxins, utilizing the body's Qi and Blood to transform into bone-like structures. Alternatively, upon birth, pressing the muscles may reveal brittle bone-like structures caused by congenital transmission and the intermingling of essence and blood. As the person grows, swelling suddenly erupts at these sites, forming an ulcer. After ulceration, the bone-like structures detach, and the wound closes. However, if bone-like structures continue to discharge endlessly, it is called Gu Zhang (Bone Distension), which is difficult to cure. For both causes, the treatment is the same: use Ge Fu Zi Moxibustion (Moxibustion with Prepared Aconite Slice) and regular moxibustion to dispel cold stagnation and accelerate bone detachment. Since bone belongs to the Kidney and congeals with cold, it is treated using heat methods.