《素问》云∶ 疟皆生于风，其蓄作有时，何气使然？夫阴阳上下交争，虚实相移也。
阳并于阴，阴实阳虚，寒栗鼓颔。此皆夏伤于暑，热气藏于皮肤之内，肠胃之外。腠理开，
得秋气，汗出遇风，得之与卫气并。卫气昼行阳，夜行阴，气得阳外出，得阴内薄，外内
相薄，是以日作也。其有间日者，气深，内薄于阴，阳气独发，阴邪内着，阴与阳争不得出，
是以间日作也。其作晏与早者，邪气客于风府，循膂而下，卫气一日一夜大会于风府，其日
下一节，先
客于脊背，每至风府则腠理开，腠理开则邪气入，则病作晏也。
夫寒者阴气也，热者阳气也，先伤寒而后伤风，故先寒而后热，名曰寒疟。先伤于风，后
伤寒，故先热而后寒，名曰温疟。其但热而不寒者，阴气先绝，阳气独胜，少气烦冤，手足
热，欲呕，名曰痹疟。
有余则泻，不足补。热为有余，寒为不足。寒已得火不能温，热已冰水不能凉。阴胜并
于阳，阳胜并于阴，阴胜则寒，阳胜则热。故疟者，阴阳风寒虚实邪气不常之所作也。
辟邪丹 治岚瘴鬼疟食疟并月频日者。
绿豆 雄黑豆（各四十九粒） 信砒（半钱，别研） 黄丹（一钱，为衣） 朱砂（二钱）
上为末，同入乳钵内，滴水为丸，分作三十粒，每服一粒，已用东南桃心，取七枝，研
汁，将井花水早辰日出不出，向日吞之，醋汤亦得。已发日服。
斩邪丹 治诸般疟疾无时不止者。
绿豆 小豆（各三十粒，口退皮再入） 朱砂 信砒（各一钱）
上为末，同研细，滴水和丸，匀分作十丸，每服一丸，已早辰服，夜间于北斗下香水献
至早晨，用新倒流水
送下。
断魔如圣丹 治疟疾，不问久新。
信砒（一钱） 蜘蛛（大者三个） 雄黑豆（四十九粒）
上为末，滴水和丸，如豌豆大，如来日发，于今晚夜北斗下献于早晨，已纸裹，于耳内扎一丸。
立见愈，神圣！一粒可医三人。
辰砂丸 治一切脾胃虚，疟邪热毒者。
信砒 甘草（各一钱） 朱砂（三钱） 大豆（四十九粒）
上为末，滴水和丸，匀分作四十丸服，发日早晨日欲出，煎桃心汤下。忌热物。
疟神丹 治诸般疟疾。
信砒（一两） 雄黄（一钱）
上以于五月重五日，用棕子尖拌匀，研三千下，日未出，不令鸡、犬、妇人见，丸如
桐子大，未发前一日面东冷水下一丸。
趁鬼丹 治一切疟疾。神效！
信砒（一钱） 大豆（七钱） 雄黄 轻粉 荷叶（各半钱） 甘草（一寸）
上为末，滴水为丸，如小豆大，重午日未出，不见鸡、犬、妇人修合，每服一丸，无根
水下，平日夜视北斗，来日服。忌热物。
《素问》说：疟疾都是由风邪引起的，发作和休止都有定时，是什么气造成的呢？这是因为阴阳之气上下交争，虚实相互转移。
阳气并入阴分，导致阴气实而阳气虚，出现寒战、鼓颔（下巴打颤）的症状。这都是因为夏天被暑热所伤，热气潜伏在皮肤之内、肠胃之外。当腠理（皮肤纹理及汗孔）开泄时，遇到秋天的凉气，出汗后受风，邪气便与卫气相并合。卫气白天行于阳分，夜晚行于阴分，邪气随卫气出于阳分，或迫入阴分，内外邪气相搏，所以每天发作。
其中有隔日发作的，是因为邪气较深，内迫于阴分，阳气单独外发，阴邪内伏，阴气与阳气相争而不能外出，所以隔日发作。
发作时间晚或早的，是因为邪气客居于风府穴，沿着脊柱向下行走。卫气一天一夜在风府穴大会一次，其位置每日向下移动一节。邪气先客居在脊背，每当卫气到达风府穴时，腠理就开泄，腠理开泄则邪气深入，所以发病时间推迟（变晚）。
寒属于阴气，热属于阳气。先感受寒邪而后感受风邪，所以先恶寒而后发热，称为寒疟。先感受风邪而后感受寒邪，所以先发热而后恶寒，称为温疟。只有发热而没有恶寒的，是因为阴气先竭绝，阳气独盛，表现为气短、心中烦闷郁结、手足发热、想呕吐，称为痹疟。
有余的证候用泻法，不足的证候用补法。热证属于有余，寒证属于不足。寒证即使得到火疗也不能温暖，热证即使得到冰水也不能清凉。阴胜则并入阳分，阳胜则并入阴分，阴胜则表现为寒，阳胜则表现为热。所以疟疾，是由于阴阳、风寒、虚实等邪气变化无常所造成的疾病。
辟邪丹：治疗岚瘴鬼疟、食疟以及每月频繁发作的疟疾。
绿豆、雄黑豆（各四十九粒）、信砒（半钱，单独研磨）、黄丹（一钱，作为包衣）、朱砂（二钱）。
以上药物研为细末，一同放入乳钵中，滴加清水制成丸药，分为三十粒。每次服用一粒，先用东南方向的桃心七枝，研磨取汁，在早晨日出前后，面向太阳吞服，也可以用醋汤送服。在疟疾发作当天服用。
斩邪丹：治疗各种无休止发作的疟疾。
绿豆、小豆（各三十粒，去皮后再放入）、朱砂、信砒（各一钱）。
以上药物研为细末，一同仔细研磨，滴加清水制成丸药，均匀分为十丸。每次服用一丸，在早晨服用；夜间在北斗星下向香水献祭至早晨，用新接的流动冷水送服。
断魔如圣丹：治疗疟疾，不论病程新旧。
信砒（一钱）、蜘蛛（大的三个）、雄黑豆（四十九粒）。
以上药物研为细末，滴加清水制成丸药，大小如豌豆。如果次日发作，在今晚夜间于北斗星下献祭至早晨，用纸包裹，将一丸塞入耳内。立刻见效，非常神圣！这一粒药可以医治三个人。
辰砂丸：治疗一切脾胃虚弱、疟邪热毒的患者。
信砒、甘草（各一钱）、朱砂（三钱）、大豆（四十九粒）。
以上药物研为细末，滴加清水制成丸药，均匀分为四十丸服用。在发作日的早晨，太阳将要出来时，煎煮桃心汤送服。忌食热性食物。
疟神丹：治疗各种疟疾。
信砒（一两）、雄黄（一钱）。
以上药物在五月重五日（端午节），用粽子尖拌匀，研磨三千次。在太阳未出之前制作，不让鸡、狗、妇人看见。制成如梧桐子大小的丸药，在发作前一天早晨，面向东方用冷水送服一丸。
趁鬼丹：治疗一切疟疾。效果神奇！
信砒（一钱）、大豆（七钱）、雄黄、轻粉、荷叶（各半钱）、甘草（一寸长）。
以上药物研为细末，滴加清水制成丸药，大小如小豆。在端午日太阳未出之前制作，不见鸡、狗、妇人。每次服用一丸，用无根水（雨水或露水）送服，平日夜间注视北斗星，次日再服用。忌食热性食物。
The *Suwen* states: All malaria arises from wind pathogens. Why do they have specific times for accumulation and cessation? It is due to the mutual contention of Yin and Yang above and below, and the shifting between deficiency and excess.
When Yang merges into Yin, Yin becomes full and Yang becomes deficient, resulting in chills and trembling of the jaw (Guhan). This occurs because summer heat injury causes heat qi to hide within the skin but outside the stomach and intestines. When the couli (pores) are open, autumn qi arrives; sweat is produced and wind is encountered. The pathogen combines with the Wei Qi (Defensive Qi). Wei Qi travels through the Yang meridians during the day and the Yin meridians at night. When the pathogen follows Wei Qi outward to the Yang level or inward to the Yin level, the external and internal levels contend with each other, causing daily attacks.
In cases where attacks occur every other day, the pathogen is deep, pressing inward on the Yin level. Yang Qi alone flares outward, while Yin pathogens remain fixed internally. Yin and Yang contend but cannot exit, hence the every-other-day attacks.
Regarding late or early onset: The pathogen lodges in the Fengfu point (GV16), moving down along the Du Meridian. Wei Qi convenes at Fengfu once a day and night, moving down one vertebral segment each day. The pathogen first lodges in the back. Whenever it reaches Fengfu, the couli open. When the couli open, the pathogen enters deeply, causing the disease to manifest later.
Cold belongs to Yin Qi, and heat belongs to Yang Qi. If cold is injured first and then wind, there is initial cold followed by heat, named Cold Malaria (Han Nue). If wind is injured first and then cold, there is initial heat followed by cold, named Warm Malaria (Wen Nue). If there is only heat without cold, it is because Yin Qi has exhausted first, leaving Yang Qi in sole dominance. Symptoms include shortness of breath, vexation, heat in the hands and feet, and nausea, named Bi Malaria.
Excess conditions require purging; deficiency conditions require tonifying. Heat is excess; cold is deficiency. Cold cannot be warmed even by fire; heat cannot be cooled even by ice. When Yin overcomes and merges into Yang, or Yang overcomes and merges into Yin, Yin excess manifests as cold, and Yang excess manifests as heat. Thus, malaria is caused by the irregular actions of Yin-Yang, Wind-Cold, and Deficiency-Excess pathogens.
Pixie Dan (Expel Evil Pill): Treats Lan-zhang ghost malaria, food-induced malaria, and frequent monthly attacks.
Mung Bean, Black Soybean (49 grains each), Realgar Arsenic (Xin Pi, 0.5 qian, ground separately), Red Lead (Huang Dan, 1 qian, used as coating), Cinnabar (Zhu Sha, 2 qian).
Grind all into powder, mix in a mortar, add drops of water to form pills, divide into 30 pills. Take one pill per dose. First, take seven heartwood pieces from a peach tree growing in the southeast direction, grind them to extract juice. Swallow the pill facing the sun in the early morning before sunrise, or use vinegar water. Take on the day of the attack.
Zhanxie Dan (Sever Evil Pill): Treats various types of malaria that do not cease.
Mung Bean, Adzuki Bean (30 grains each, peeled and returned to mixture), Cinnabar, Realgar Arsenic (1 qian each).
Grind into fine powder, mix thoroughly, add water to form pills, divide evenly into 10 pills. Take one pill in the morning. At night, offer incense to the Big Dipper until morning, then swallow with fresh running water.
Duanmo Rusheng Dan (Demon-Breaking Holy Pill): Treats malaria, regardless of duration.
Realgar Arsenic (1 qian), Large Spiders (3), Black Soybean (49 grains).
Grind into powder, add water to form pills the size of pea seeds. If an attack is expected tomorrow, perform offerings to the Big Dipper tonight until morning. Wrap one pill in paper and insert it into the ear. Cure will be seen immediately; this is divine! One pill can treat three people.
Chensha Wan (Cinnabar Pill): Treats all cases of Spleen-Stomach deficiency with malaria pathogen heat toxicity.
Realgar Arsenic, Licorice Root (Gan Cao, 1 qian each), Cinnabar (3 qian), Soybean (49 grains).
Grind into powder, add water to form pills, divide evenly into 40 pills. On the morning of the attack, when the sun is about to rise, swallow with decoction of peach heartwood. Avoid hot foods.
Mashen Dan (Malaria God Pill): Treats all types of malaria.
Realgar Arsenic (1 liang), Realgar (Xiong Huang, 1 qian).
On the fifth day of the fifth lunar month, mix with the tip of a zongzi leaf, grind 3,000 times. Prepare before sunrise; ensure no chickens, dogs, or women see the process. Form pills the size of paulownia seeds. The day before the attack, face east and swallow one pill with cold water.
Chengui Dan (Chase Ghost Pill): Treats all types of malaria. Extremely effective!
Realgar Arsenic (1 qian), Soybean (7 qian), Realgar, Calomel (Qing Fen), Lotus Leaf (He Ye, 0.5 qian each), Licorice Root (1 cun length).
Grind into powder, add water to form pills the size of adzuki beans. Prepare on the fifth day of the fifth lunar month before sunrise; ensure no chickens, dogs, or women witness the preparation. Take one pill per dose with unrooted water (rain/dew). Observe the Big Dipper at night daily, and take the next dose the following day. Avoid hot foods.