小儿患痘，日至八九充灌回谢，宜保全矣。然有回至颈项而死者；有回至胸前而死
者；有回至脐上而死者；有回至阳球而死者，其故何欤？盖因元气薄劣，痘密毒重，
峻用毒物以发之，又投升动之剂，尽将元气赶上，发泄殆尽，是以痘虽充灌，不知外囊
实而里耗竭，五经伤而不能干补，故颈上喉突，气窝肺之关辖也。肺气先绝，则回至此
馘绊而死胸乃心管辖也。心气先绝，则回至此馘绊而死脐乃脾之关辖也。脾气先绝，则
回至此馘绊而死，眼眶肝之关辖也。肝气先绝，则回至此，馘绊而死，阳球肾之关辖
也，肾气先绝，则回至此馘绊而死，盖本拔则木枯，源塞则流涸、自然之理。若能预调
气而使痘毒连化于自然，则元气无伤，何有秀而不实之患哉！
（内有未备者悉具总论痘要门参看）
凡痘自初出以来，表里俱病，迨至收靥之日，则表邪已解，里气当和，大便宜润，
小便宜清。如反忽尔洞泻水谷者，此因中气暴虚而不能禁固，毒瓦斯乘虚入里，欲休倒靥
反祛木谷耳，宜用异攻散主之。如利止者化。否则，必阳脱而死。至若利下痂皮脓而
者，是正不受邪，被动毒出外，毒尽自已，推调气血解余毒，以助营运，惟出之势，勿
为止涩也。
痘靥之后，若失调理，或伤饮食，或感风湿，以致伤脾，脾虚则不能治水，水溢上
行，故为浮肿也。如因饮食伤者，则用健脾利水。如因风湿伤者，则以汗解之。然久病
之后，五内皆虚，脾不能运而气多滞，肺不能输而气不降，肾不能纳而气不藏，所以无
根失守之气，任其升降，卧则面浮，起则脚肿，恒多有之。但调五内，浮肿自愈，舍本
治肿，终无益也。
小儿患痘疮，到了第八九天的充灌期及回浆期，本应保全性命。然而，有的患儿痘毒退至颈部便死亡；有的退至胸前便死亡；有的退至肚脐上方便死亡；有的退至阴囊便死亡，这是什么原因呢？这是因为元气薄弱低劣，痘疹密集且毒性沉重，医生峻烈地使用有毒的药物来发散痘毒，又投用升提发动的药剂，导致元气被强行调动，发泄殆尽。因此，虽然痘疹看似充灌饱满，但实际上外部的“囊”（痘形）虽实，内部的元气却已耗竭。五脏经脉受损，无法进行补益。所以，颈部和喉部是肺气的关辖所在，肺气先绝，则痘毒在此处受阻绊而死亡；胸部是心气管辖所在，心气先绝，则痘毒在此处受阻绊而死亡；肚脐是脾气关辖所在，脾气先绝，则痘毒在此处受阻绊而死亡；眼眶是肝气关辖所在，肝气先绝，则痘毒在此处受阻绊而死亡；阴囊是肾气关辖所在，肾气先绝，则痘毒在此处受阻绊而死亡。这就像树根拔除树木就会枯死，水源堵塞水流就会干涸，是自然的道理。如果能够预先调理气机，使痘毒自然化解，那么元气就不会受伤，哪里还会有只开花不结果（秀而不实）的祸患呢！
（书中若有未详尽之处，请参见总论中的《痘要门》章节参考。）
凡是痘疮从初出以来，表里都受病邪影响，等到收靥（结痂脱落）的日子，表邪已经解除，里气应当调和，大便宜润通，小便宜清利。如果反而突然发生水谷不分的洞泻，这是因中气突然虚弱而不能固摄，毒瓦斯乘虚侵入体内，想要休止倒靥（痘疮内陷），反而阻碍了水谷精微的吸收，此时宜用异攻散主治。如果腹泻停止，说明病情好转。否则，必然阳气脱失而死。至于那些排出带脓血的痘皮屑的，这是正气不受邪气干扰，被动将毒邪排出体外，毒尽自会痊愈，应当调理气血以解除余毒，帮助营卫运行，顺应痘毒外出的趋势，不要使用止涩的药物。
痘疮结痂之后，如果失去调理，或者饮食不当，或者感受风湿，以致损伤脾脏。脾虚则不能运化水湿，水湿溢出上行，所以出现浮肿。如果是因饮食损伤引起的，就用健脾利水的方法治疗。如果是因风湿损伤引起的，就用发汗解表的方法治疗。然而久病之后，五脏内部皆虚，脾不能运化而气多停滞，肺不能输布而气不下降，肾不能纳气而气不收藏，所以这种无根、失守的气，任由其升降无序，躺着时面部浮肿，站起来时脚部肿胀，这种情况很常见。只要调理五脏内部，浮肿自然会痊愈，舍弃根本而去治疗浮肿，终究没有益处。
When a child suffers from smallpox, by the eighth or ninth day, during the stage of filling and pustulation or resolution, life should be preserved. However, some children die when the eruption recedes to the neck; some die when it recedes to the chest; some die when it recedes above the umbilicus; some die when it recedes to the scrotum. What is the reason for this? It is due to deficient and weak Yuan Qi (Vital Energy), dense eruptions with heavy toxicity, and the harsh use of toxic substances to induce eruption, combined with the administration of ascending and activating agents. This forces all the Yuan Qi upward, exhausting it completely. Thus, although the eruptions appear full, the exterior "sac" (pustule shape) may seem solid while the interior is depleted. The five meridians are injured and cannot be supplemented. Therefore, the neck and throat are the gatekeepers of Lung Qi (Lung Vital Energy); if Lung Qi fails first, the eruption is blocked here, leading to death. The chest is governed by Heart Qi (Heart Vital Energy); if Heart Qi fails first, the eruption is blocked here, leading to death. The umbilicus is the gatekeeper of Spleen Qi (Spleen Vital Energy); if Spleen Qi fails first, the eruption is blocked here, leading to death. The eye sockets are governed by Liver Qi (Liver Vital Energy); if Liver Qi fails first, the eruption is blocked here, leading to death. The scrotum is the gatekeeper of Kidney Qi (Kidney Vital Energy); if Kidney Qi fails first, the eruption is blocked here, leading to death. This is like pulling up the roots causing trees to wither, or blocking the source causing streams to dry up—a natural law. If one can pre-adjust the Qi so that the smallpox toxin resolves naturally, then Yuan Qi will not be damaged, and there will be no worry of "blooming without fruiting" (failure to mature).
(For details not covered herein, please refer to the General Discussion section on "Essentials of Smallpox".)
Since the initial appearance of smallpox, both the exterior and interior are diseased. By the time of crusting and resolution (Shou Ye), the exterior pathogenic factors should have been resolved, and the interior Qi should be harmonious. Stool should be moistened, and urine should be clear. If sudden watery diarrhea of undigested food occurs instead, this is because the Middle Qi (Middle Jiao Energy) has suddenly become deficient and unable to secure retention. The toxic vapors enter the interior in the absence of resistance, attempting to halt the crusting process but instead obstructing the transformation of grain and water. In such cases, Yigong San (Heterogeneous Attack Powder) should be used as the primary formula. If the diarrhea stops, the condition transforms favorably. Otherwise, Yang collapse (Yang Tuo) will occur, leading to death. As for those who pass pus-tinged crusts, this indicates that the Righteous Qi (Zheng Qi) is not invaded by pathogens, but rather the passive expulsion of toxins outward. Once the toxins are exhausted, recovery will follow naturally. One should regulate Qi and Blood to resolve residual toxins and assist Ying (Nutritive) and Wei (Defensive) circulation, following the trend of toxin expulsion, and must not use astringent methods to stop it.
After the smallpox crusts fall off, if proper care is neglected, or if diet is improper, or if Wind-Dampness is contracted, the Spleen may be injured. When Spleen deficiency occurs, it cannot transport water, causing water to overflow and rise, resulting in edema (Swelling). If caused by dietary injury, employ methods to strengthen the Spleen and promote diuresis. If caused by Wind-Dampness, employ sweating methods to release the exterior. However, after prolonged illness, the five Zang organs are all deficient. The Spleen cannot transport, leading to Qi stagnation; the Lung cannot distribute, leading to descending failure of Qi; the Kidney cannot grasp Qi, leading to failing to store Qi. Consequently, rootless and unanchored Qi rises and falls aimlessly. It is common for the face to swell when lying down and the feet to swell when standing. Simply regulating the five Zang organs will allow the edema to heal itself. Abandoning the root to treat only the swelling is ultimately of no benefit.