论曰唇生核之候，大概与唇疮紧唇相类，然其肿至于生核者，盖足阳明与太阴为表里，
脏腑俱有风热，风热之气，冲发二经，与血气相搏而为唇肿，外复为风冷所乘，血气凝结，
聚而不散，故生核也。
治脾胃蕴积热气，复为风冷相搏，唇边生核，结硬疼痛，防风汤方
防风（去叉半两） 菊花（一两） 升麻 独活（去芦头） 知母（焙） 黄芩（去黑
心） 玄参
本（去苗
（炙锉） 麦
门冬（去心焙
上一十五味，粗捣筛，每用三钱匕，水一盏，煎至七分，去滓食后服、日三。
治脾胃风热，唇生核。地黄煎方
生地黄（汁一升） 生麦门冬（去心） 生天门冬（去心） 葳蕤（各四两） 细辛（去
苗叶）
甘草（炙） 芎 白术（各二两） 黄 升麻（各三两）
上一十味，除地黄汁外，并锉细，以绵裹，苦酒浸一宿，取出更用猪膏三升煎，滤过下
地黄汁，并绵裹者药同煎，以膏鸣水脉尽为度，去滓盛贮，每以少许，细细含化，缓咽之。
治脾胃有热，风冷相乘，唇肿生核疼痛。升麻饮方
升麻 前胡（去芦头） 犀角（镑各半两） 龙胆 青竹皮 葛根（锉各一分） 薏苡
仁甘
草（炙锉各半两）
上八味，粗捣筛，每服五钱匕，水一盏半，煎至八分，去滓食后服。
治脾胃积热，风冷乘之，唇肿结核。黄连散方
黄连（去须） 升麻 龙胆（各一两）
上三味，捣罗为散，绵裹如弹子大，临卧以新汲水浸过，含化咽津。
治唇肿生核。恶实散方
恶实（炒） 乌梅（去核各半两） 甘草（炙锉一分）
上三味，捣罗为散，每服三钱匕，童子小便一盏，煎至三五沸，和滓乘热含漱冷吐，日
三。
治唇生核，肿痛如弹方
牛膝（烧灰存性研）
上一味，先以针刺出恶血，次用药少许，以新汲水，调涂核上。
治唇黑肿生核，痛痒不可忍方
古铜钱（青者四文）
上一味，于石上以腊月猪脂，磨取汁涂之。
论述说：唇部生核的症状，大体上与唇疮、嘴唇紧缩相似，然而其肿胀发展到形成硬结的，是因为足阳明胃经与足太阴脾经互为表里，脏腑内部都有风热之邪。风热之气冲激并引发这两条经络，与气血相互搏结而导致嘴唇肿胀；外部又受到风冷邪气的侵袭，导致气血凝结，聚积而不消散，因此形成了硬结。
治疗脾胃蕴积热气，又受风冷邪气搏击，在唇边生核，结块坚硬且疼痛的方剂——防风汤方：
防风（去除叉枝半两）、菊花（一两）、升麻、独活（去除芦头）、知母（焙干）、黄芩（去除黑心部分）、玄参、本（去苗，炙后锉碎）、麦门冬（去心，焙干）。以上十五味药，粗捣筛过，每次取三钱匕，用水一盏，煎煮至七分满，滤去药渣，饭后服用，每日三次。
治疗脾胃风热，唇部生核的方剂——地黄煎方：
生地黄（取汁一升）、生麦门冬（去心）、生天门冬（去心）、葳蕤（各四两）、细辛（去苗叶）、甘草（炙）、川芎、白术（各二两）、黄芪、升麻（各三两）。以上十味药，除地黄汁外，其余均锉细，用绵布包裹，在醋中浸泡一夜，取出后再用猪脂油三升煎煮，过滤后加入地黄汁，并将包裹药物的绵布一同放入煎煮，直到膏状物中的水分蒸发殆尽为止，滤去药渣盛装储存。每次取少许，细细含化，缓慢咽下。
治疗脾胃有热，风冷邪气乘虚而入，导致嘴唇肿胀生核且疼痛的方剂——升麻饮方：
升麻、前胡（去芦头）、犀角（镑片，各半两）、龙胆、青竹皮、葛根（锉碎，各一分）、薏苡仁、甘草（炙后锉碎，各半两）。以上八味药，粗捣筛过，每次服用五钱匕，用水一盏半，煎煮至八分满，滤去药渣，饭后服用。
治疗脾胃积热，风冷邪气侵袭，导致嘴唇肿胀结成硬块的方剂——黄连散方：
黄连（去须）、升麻、龙胆（各一两）。以上三味药，捣碎研磨成散剂，用绵布包裹如弹子大小，临睡前用新汲取的井水浸泡，含化后咽下津液。
治疗嘴唇肿胀生核的方剂——恶实散方：
牛蒡子（炒制）、乌梅（去核，各半两）、甘草（炙后锉碎，一分）。以上三味药，捣碎研磨成散剂，每次服用三钱匕，用童子小便一盏，煎煮至沸腾三五次，连同药渣一起趁热含漱，冷却后吐出，每日三次。
治疗唇部生核，肿痛如同弹丸的方剂：
牛膝（烧成灰但保留药性，研细）。以上一味药，先用针刺破排出恶血，然后取少量药物，用新汲取的水调匀涂抹在硬结上。
Commentary states: The manifestation of nodules forming on the lips is generally similar to lip sores (Chuang) and lip retraction (Jin Chun). However, when the swelling progresses to form distinct nodules, it is because the Foot-Yangming Stomach Channel and the Foot-Taiyin Spleen Channel are exterior-interior paired. Wind-heat pathogenic factors exist within the Zang-Fu organs. The wind-heat qi attacks and stimulates these two channels, clashing with Qi and Blood, resulting in lip swelling. Externally, the area is further invaded by wind-cold pathogens, causing Qi and Blood to coagulate, accumulate, and fail to dissipate, thus generating nodules.
Formula for treating heat accumulation in the Spleen and Stomach, combined with wind-cold clash, resulting in nodules on the lip margin that are hard, knotted, and painful: Fangfeng Tang (Saposhnikovia Decoction).
Fangfeng (Radix Saposhnikoviae, half liang, forked parts removed), Juhua (Flos Chrysanthemi, one liang), Shengma (Rhizoma Cimicifugae), Duhuo (Radix Angelicae Pubescentis, radix tip removed), Zhimu (Cortex Anemarrhenae, roasted), Huangqin (Radix Scutellariae, black heart removed), Xuanshen (Radix Scrophulariae), Bencao (Radix Ligustici, seedlings removed), Baizhi (Radix Angelicae Dahuricae, roasted and crushed), Maidong (Tuber Ophiopogonis, core removed and roasted). Fifteen ingredients in total. Coarsely crush and sieve. For each dose, use three Qianbi (approx. 4.5g), add one Jian (approx. 200ml) of water, decoct until reduced to seven-tenths. Strain and take after meals, three times daily.
Formula for treating wind-heat in the Spleen and Stomach, resulting in nodules on the lips: Dihuang Jian (Rehmannia Paste).
Shengdihuang (Fresh Radix Rehmanniae, juice one Sheng), Sheng Maidong (Fresh Tuber Ophiopogonis, core removed), Sheng Tianmendong (Fresh Tuber Asparagi, core removed), Ruiyu (Rhizoma Polygonati Odorati, four liang each), Xixin (Herba Asari, seedlings and leaves removed), Gancao (Radix Glycyrrhizae, roasted), Xiong (Rhizoma Chuanxiong), Baizhu (Rhizoma Atractylodis Macrocephalae, two liang each), Huangqi (Radix Astragali), Shengma (Rhizoma Cimicifugae, three liang each). Ten ingredients in total. Except for the fresh Rehmannia juice, finely chop the remaining herbs, wrap in silk cloth, and soak in vinegar (Ku Jiu) overnight. Remove and decoct with three Sheng of lard (Zhu Gao). Filter, then add the Rehmannia juice and the silk-wrapped herbs back into the mixture. Decoct until the moisture in the lard evaporates completely. Strain and store. Take a small amount, hold in the mouth to dissolve slowly, and swallow gradually.
Formula for treating heat in the Spleen and Stomach with wind-cold invasion, causing lip swelling, nodules, and pain: Shengma Yin (Cimicifuga Drink).
Shengma (Rhizoma Cimicifugae), Qianhu (Radix Peucedani, radix tip removed), Xijiao (Cornu Rhinocerotis, sliced, half liang each), Longdan (Radix Gentianae), Qingzhupi (Pericarpium Citri Reticulatae Viride), Gegen (Radix Puerariae, chopped, one fen each), Yiyiren (Semen Coicis), Gancao (Radix Glycyrrhizae, roasted and chopped, half liang each). Eight ingredients in total. Coarsely crush and sieve. For each dose, use five Qianbi, add one and a half Jian of water, decoct until reduced to eight-tenths. Strain and take after meals.
Formula for treating accumulated heat in the Spleen and Stomach with wind-cold invasion, causing lip swelling and tubercles: Huanglian San (Coptis Powder).
Huanglian (Rhizoma Coptidis, roots removed), Shengma (Rhizoma Cimicifugae), Longdan (Radix Gentianae, one liang each). Three ingredients in total. Crush and grind into powder. Wrap in silk cloth into a size resembling an egg yolk. Before sleep, soak in fresh well water, hold in the mouth to dissolve, and swallow the saliva.
Formula for treating lip swelling and nodules: Eshi San (Arctium Powder).
Eshi (Fructus Arctii, stir-fried), Wumei (Fructus Mume, pitted, half liang each), Gancao (Radix Glycyrrhizae, roasted and chopped, one fen). Three ingredients in total. Crush and grind into powder. For each dose, use three Qianbi, add one Jian of urine from a young boy (Tongzi Xiaoyin), boil for three to five boils. Hold the mixture (including dregs) warm in the mouth, gargle, and spit out when cool. Three times daily.
Formula for treating lip nodules with swelling and pain resembling a bean: Niuxi (Radix Achyranthis Bidentatae). One ingredient. First, prick with a needle to drain bad blood. Then, take a small amount of the powdered herb, mix with fresh well water, and apply to the nodule.
Formula for treating black, swollen lips with nodules, unbearable itching and pain: Gu Tongqian (Ancient Copper Coins, greenish ones, four coins). One ingredient. Grind the coins on a stone surface using lard from the twelfth lunar month to extract the juice, and apply to the affected area.