凡药相对者误服。以防解救诸法。附列于下。
钟乳对术。其治主肺。上通头胸。术动钟乳。胸塞短气。钟乳动术。头痛目疼。又钟乳虽不
对海蛤。海蛤能动钟乳。然钟乳与术为患。不过此也。发动之始。体中有异。与上患相应。速宜
服葱白、香豉、甘草、吴茱萸汤解之。才服便令人按摩摇动。口中嚼物。然后仰卧覆汗。汗出去
覆。服汤热歇。即用冷淘饭压之。若服不解。复用前汤去萸加桂。若已解。肺家尚有余热。第二
方加麦门冬。
硫黄对防风。又对细辛。其治主脾肾。通主腰。防风动硫黄。烦热脚疼腰痛。或嗔忿无常。
或下痢不禁。防风、细辛能动硫黄。硫黄不能动彼。始觉发。便宜服杜仲、枳实、甘草、香豉、
栀子、李核仁。服如上法。不解。复服大麦奴、甘草、人参、芒硝、桂心、麦门冬。若服此已解。
犹有余热气。或冷。复服人参、干姜、附子、甘草、当归。
白石英对附子。其治主胃。通主脾肾。附子动白石英。烦热腹胀。白石英动附子。呕逆不得
食。或口噤不开。或手足疼痛。始觉宜服麦门冬、甘草、麻黄、香豉。不解再。服大黄、香豉、
栀子、甘草。服如上法。频服汤。下便止。不下再服。若热势未除而渴。复服栝蒌根、大麦奴、
甘草、葱、豉。若已解。胃中有余热。复服芒硝、桂心、通草、甘草、白术、大枣、李核仁。
紫石英对人参。其治主心肝。通主腰脚。人参动紫石英。心急而痛。或惊悸不得眠卧。恍惚
忘误。失性发狂。乍寒乍热。耳聋目暗。始觉宜服人参、白术、甘草、桂心、细辛、香豉。服如
上法。若嗔盛。加大黄、黄芩、栀子。若忘误狂发未除。复服葱
白、香豉、麦门冬、甘草、人参。服如上法。温覆。使身稍汗便解。若有余热。更服人参、防风、
桂心、白术、生姜。
赤石脂对桔梗。其治主心。通主胸背。桔梗动石脂。心痛寒噤。手足逆冷。心中烦闷。赤石
脂动桔梗。头痛目赤。身体壮热。始觉发。便宜温酒饮之。须酒势行则解。或大麦炒令汗出。勿
焦。捣筛细末。冷水和服。
矾石无所偏对。其治主胃。发则令人心急口噤。骨节强痛生疮。始觉发。即服葱白、香豉、
甘草汤。若发身体即便生疮。宜服麦门冬、人参、甘草、桂心、葱白、香豉。
附子对白石英。亦对赤石脂。附子发则呕逆脚疼体强。骨节痛面肿。发则饮酒服热面自愈。
与白石英同解。
赤石脂、紫石英发。宜饮酒。得酒则解。凡药发。或有宜饮热酒。不可一概也。
以上解救发对八则。出千金方。
金太傅孙古修。误服伏火丹砂。中毒。恳治于石顽。察其本元素亏。近因虚火上炎。吞下肿
胀。延及两颐。医用苦寒清热太过。神思不宁。药中每服加丹砂五钱。甫进一剂。觉胸中有物触
有数次。次早请政于医。复出丹砂视之。色黑而晦。丹炉中伏火砂也。医令易砂。更服四剂。昼
夜烦躁不宁。背时洒淅恶寒。头面哄热大汗。胫膝逆冷如冰。忽忽气逆欲绝。医目瞪无措。乃延
石顽诊之。六脉涩数模糊。次验唇舌。俱色如污泥。而肿浓湿滑。若系热极似阴。必无湿滑之理。
若系寒犯三阴。必无反浓之理。惟酒食内蕴。霉酱色现有之。审其二便调适。胸腹柔和。决无实
停胃府之理。证虽危疑。而恳致最切。以脉合证。洵为阴受热郁。今所最急者。恐其喘汗欲脱。
不获已以生脉、六味合剂。庶几金水相生以救肺肾之垂绝。进一服。神思稍安。自汗稍敛。再一
服人事稍知。稀糜稍进。方能略述从前所患
之病。出从前所用之方。犹未言及伏火砂也。见其舌沿稍转微红。而气微足冷如故。于前方中益
入桂心五分。五味数粒。服后足稍温和。气稍接续。语稍有次。方详述伏火丹砂之误。因以前方
减去地黄、桂心、五味。易入枣仁、秋石、人中黄。专解丹砂之毒。三服舌转微红。虽未鲜洁。
而伏毒渐解。缘两尺弦细。乃去人中黄。仍用地黄以填补下元。数日之间。或去人中黄而用地黄。
或去地黄而用人中黄。随脉证而更迭出入。二味不兼用者。恐人中黄味甘恋膈。载地黄之腻。不
能速达下焦也。下元虽亏。调补药中。宁用鹿茸、河车。不敢用桂、附者。虑其鼓舞丹砂之余烈也。
凡是药物相互拮抗（药对）被误服后，为了防止其产生危害并解救，现将各种解救方法附列如下。
钟乳石与白术相对。钟乳石的药效主要作用于肺，向上通达头胸部位。若白术扰动钟乳石，会导致胸部堵塞、呼吸短促；若钟乳石扰动白术，则会导致头痛、眼睛疼痛。此外，虽然钟乳石不与海蛤相克，但海蛤能扰动钟乳石。然而，钟乳石与白术相克产生的危害，不过如此而已。在药性发动之初，身体会有异常反应，与上述症状相应。此时应迅速服用葱白、香豉、甘草、吴茱萸汤来解毒。服药后立即让人按摩并摇动身体，口中咀嚼食物，然后仰卧覆盖衣被以发汗。汗出后去掉覆盖物，待喝下的汤药热度消退后，立即用冷淘饭按压胃部以制约药力。如果服药后未能解除，再次服用前面的汤药，去掉吴茱萸加入桂枝。如果已经解除，肺部尚有余热，则在第二个方剂中加入麦门冬。
硫黄与防风相对，也与细辛相对。硫黄的药效主要作用于脾肾，主要通达腰部。若防风扰动硫黄，会导致烦热、脚痛腰痛，或者情绪无常易怒，或者腹泻不止。防风、细辛能动摇硫黄，但硫黄不能动摇它们。刚开始感觉发作时，应立即服用杜仲、枳实、甘草、香豉、栀子、李核仁。服用方法同上。如果未解除，再服用大麦奴、甘草、人参、芒硝、桂心、麦门冬。如果服用此方后已解除，但仍有热气或寒气残留，再服用人参、干姜、附子、甘草、当归。
白石英与附子相对。白石英的药效主要作用于胃，通达脾肾。若附子扰动白石英，会导致烦热、腹胀；若白石英扰动附子，会导致呕吐逆气、无法进食，或者牙关紧闭不开，或者手足疼痛。刚开始感觉发作时，宜服用麦门冬、甘草、麻黄、香豉。如果未解除，再服用大黄、香豉、栀子、甘草。服用方法同上。频繁服用汤药，大便通畅即停止；若不通畅则继续服用。如果热势未除且口渴，再服用栝蒌根、大麦奴、甘草、葱、豉。如果已经解除，胃中有余热，再服用芒硝、桂心、通草、甘草、白术、大枣、李核仁。
紫石英与人参相对。紫石英的药效主要作用于心肝，通达腰脚。若人参扰动紫石英，会导致心急而痛，或者惊悸无法安睡，精神恍惚健忘失误，失去本性发狂，忽冷忽热，耳聋目暗。刚开始感觉发作时，宜服用人参、白术、甘草、桂心、细辛、香豉。服用方法同上。如果怒气旺盛，加大黄、黄芩、栀子。如果健忘发狂的症状未消除，再服用葱白、香豉、麦门冬、甘草、人参。服用方法同上，温覆衣被，使身体微微出汗即可解除。如果有余热，再服用人参、防风、桂心、白术、生姜。
赤石脂与桔梗相对。赤石脂的药效主要作用于心，通达胸背。若桔梗扰动赤石脂，会导致心痛寒战，手足逆冷，心中烦闷；若赤石脂扰动桔梗，会导致头痛眼红，身体高热。刚开始感觉发作时，适宜用温酒送服。必须等到酒力运行才能解除。或者将大麦炒至出汗（不出水），不要炒焦，捣碎筛成细末，用冷水调和服用。
矾石没有特定的相对药物。矾石的药效主要作用于胃。发作时会导致人心急、牙关紧闭，骨节强痛生疮。刚开始感觉发作时，立即服用葱白、香豉、甘草汤。如果发作时身体立刻生疮，宜服用麦门冬、人参、甘草、桂心、葱白、香豉。
附子对白石英，也对赤石脂。附子发作时会导致呕吐逆气、脚痛、身体僵硬，骨节疼痛面部浮肿。发作时饮酒并吃热面条即可自愈。这与白石英的解法相同。
赤石脂、紫石英发作时，适宜饮酒，得到酒就能解除。凡药物相克发作，有的适宜饮用热酒，不可一概而论。
以上解救药物相克的八种法则，出自《千金方》。
金太傅孙古修，误服了伏火丹砂，导致中毒，恳请石顽（张璐号）治疗。诊察发现他原本体质亏虚，近期因虚火上炎，吞咽困难，肿胀延及两侧面颊。医生使用苦寒药物清热太过，导致神志不宁。用药中每服加入五钱丹砂。刚进一剂药，就觉得胸中有物体触碰，有数次之多。次日早晨请医官诊治，又拿出丹砂查看，颜色黑而晦暗，是丹炉中经过伏火处理的丹砂。医生令更换丹砂，又服用了四剂。昼夜烦躁不宁，傍晚时分洒淅恶寒，头面烘热大汗，小腿膝盖逆冷如冰，忽然气息上逆几乎断绝，医生瞪眼无措。于是延请石顽诊脉。六脉涩数模糊，其次查验唇舌，颜色都像污泥一样，而且肿胀浓湿滑腻。如果是热极似阴证，必然不会有湿滑的道理；如果是寒邪侵犯三阴经，必然不会有反常浓湿的道理。只有酒食内蕴，才会出现霉酱色。审察其二便调适，胸腹柔和，决无实邪停滞在胃腑的道理。证候虽然危重可疑，但患者恳求救治的心情最迫切。以脉象合参证候，确实是阴分受热郁结。现在最紧急的是，恐怕他会喘促汗出欲脱。不得已采用生脉散、六味地黄丸合剂，希望能通过金水相生来挽救肺肾即将衰竭的状态。进服一剂后，神志稍安，自汗稍敛。再服一剂，人事稍知，稀粥稍微能进，才能略微陈述从前所患的疾病和用过的前方，还没有提到伏火丹砂的事。看到他的舌边稍微转微红，而气息微弱、脚冷如故，于是在前方中加入桂心五分，五味子数粒。服用后脚稍微温和，气息稍微接续，说话稍微有条理。这才详细陈述误服伏火丹砂的情况。因此在前方的基础上减去地黄、桂心、五味子，换入枣仁、秋石、人中黄，专门解除丹砂的毒性。服用三剂后舌头转微红，虽然还不鲜洁，但伏毒逐渐解除。因为两尺脉弦细，于是去掉了人中黄，仍用地黄来填补下元。几天之间，有时去人中黄用地黄，有时去地黄用人中黄，随脉证变化交替出入。这两味药不兼用的原因，是担心人中黄味甘留恋膈部，携带地黄的滋腻之性，不能迅速到达下焦。下元虽然亏虚，但在调补药中，宁愿用鹿茸、紫河车，不敢用桂枝、附子的原因，是顾虑它们会鼓舞丹砂残留的烈性。
Whenever drugs that are mutually antagonistic (Yao Dui) are mistakenly ingested, to prevent harm and provide rescue, the various rescue methods are listed below.
Baitian Huan (Stalactite) opposes Baizhu (Atractylodes Rhizome). Baitian Huan's therapeutic effect primarily targets the Lung, extending upward to the head and chest. If Baizhu agitates Baitian Huan, it causes chest obstruction and shortness of breath; if Baitian Huan agitates Baizhu, it causes headache and eye pain. Furthermore, although Baitian Huan does not oppose Hai Ge (Hemimys Shell), Hai Ge can agitate Baitian Huan. However, the harm caused by the opposition between Baitian Huan and Baizhu is limited to this. At the initial stage of drug activation, there will be abnormalities in the body corresponding to the above symptoms. At this time, one should quickly take Cong Bai (Scallion White), Xiang Chi (Fermented Soybean), Gan Cao (Licorice Root), and Wuzhuyu Tang (Evodia Decoction) to detoxify. Immediately after taking the medicine, have someone massage and shake the body, chew food in the mouth, then lie supine and cover with blankets to induce sweating. After sweating, remove the covers. Once the heat of the ingested decoction subsides, immediately press the stomach with cold washed rice to restrain the medicinal force. If the medication fails to resolve the condition, take the previous decoction again, removing Wuzhuyu and adding Guizhi (Cinnamon Twig). If already resolved but residual heat remains in the Lung, add Maidong (Ophiopogon Tuber) to the second formula.
Huangqi (Sulfur) opposes Fangfeng (Saposhnikovia Root) and also opposes Xixin (Asarum Root). Huangqi's therapeutic effect primarily targets the Spleen and Kidney, mainly extending to the waist. If Fangfeng agitates Huangqi, it causes irritability, heat, leg pain, and lower back pain, or erratic anger, or uncontrollable diarrhea. Fangfeng and Xixin can agitate Huangqi, but Huangqi cannot agitate them. When the onset is first felt, one should promptly take Duzhong (Eucommia Bark), Zhishi (Immature Bitter Orange), Gan Cao (Licorice Root), Xiang Chi (Fermented Soybean), Zhizi (Gardenia Fruit), and Li He Ren (Plum Seed Kernel). Take as described above. If unresolved, take Damai Nu (Barley Sprout), Gan Cao (Licorice Root), Renshen (Ginseng Root), Mangxiao (Mirabilite), Guixin (Cinnamon Heart), and Maidong (Ophiopogon Tuber). If this prescription resolves the condition but residual heat or cold remains, take Renshen (Ginseng Root), Ganjiang (Dried Ginger), Fuzi (Prepared Aconite Root), Gan Cao (Licorice Root), and Danggui (Angelica Sinensis).
Baishiyin (White Quartz) opposes Fuzi (Prepared Aconite Root). Baishiyin's therapeutic effect primarily targets the Stomach, extending to the Spleen and Kidney. If Fuzi agitates Baishiyin, it causes irritability, heat, and abdominal distension; if Baishiyin agitates Fuzi, it causes vomiting, regurgitation, inability to eat, trismus (lockjaw), or pain in the hands and feet. When the onset is first felt, take Maidong (Ophiopogon Tuber), Gan Cao (Licorice Root), Mahuang (Ephedra Stem), and Xiang Chi (Fermented Soybean). If unresolved, take Dahuang (Rhubarb Root), Xiang Chi (Fermented Soybean), Zhizi (Gardenia Fruit), and Gan Cao (Licorice Root). Take as described above. Take the decoction frequently; stop when bowel movements occur; if no movement, continue taking. If heat persists and thirst occurs, take Gualou Gen (Trichosanthes Root), Damai Nu (Barley Sprout), Gan Cao (Licorice Root), Cong (Scallion), and Chi (Fermented Soybean). If already resolved but residual heat remains in the Stomach, take Mangxiao (Mirabilite), Guixin (Cinnamon Heart), Tongcao (Tetrapanax Pith), Gan Cao (Licorice Root), Baizhu (Atractylodes Rhizome), Dazao (Jujube Fruit), and Li He Ren (Plum Seed Kernel).
Zishiyin (Purple Quartz) opposes Renshen (Ginseng Root). Zishiyin's therapeutic effect primarily targets the Heart and Liver, extending to the waist and legs. If Renshen agitates Zishiyin, it causes heart anxiety and pain, palpitations preventing sleep, mental confusion, forgetfulness, loss of normal temperament leading to mania, alternating chills and fever, deafness, and dim vision. When the onset is first felt, take Renshen (Ginseng Root), Baizhu (Atractylodes Rhizome), Gan Cao (Licorice Root), Guixin (Cinnamon Heart), Xixin (Asarum Root), and Xiang Chi (Fermented Soybean). Take as described above. If anger is severe, add Dahuang (Rhubarb Root), Huangqin (Scutellaria Root), and Zhizi (Gardenia Fruit). If forgetfulness and mania persist, take Cong Bai (Scallion White), Xiang Chi (Fermented Soybean), Maidong (Ophiopogon Tuber), Gan Cao (Licorice Root), and Renshen (Ginseng Root). Take as described above, cover warmly to induce slight sweating for resolution. If residual heat remains, take Renshen (Ginseng Root), Fangfeng (Saposhnikovia Root), Guixin (Cinnamon Heart), Baizhu (Atractylodes Rhizome), and Shengjiang (Fresh Ginger).
Shizhizhi (Red Halloysite) opposes Jiegeng (Platycodon Root). Shizhizhi's therapeutic effect primarily targets the Heart, extending to the chest and back. If Jiegeng agitates Shizhizhi, it causes heart pain, chills, cold extremities, and mental restlessness; if Shizhizhi agitates Jiegeng, it causes headache, red eyes, and high fever. When the onset is first felt, it is appropriate to take with warm wine. Resolution requires the wine's effect to circulate. Alternatively, stir-fry Damai (Barley) until moisture appears (not burnt), grind into fine powder, and take mixed with cold water.
Fanshi (Alum) has no specific opposing drug. Fanshi's therapeutic effect primarily targets the Stomach. Upon onset, it causes heart anxiety, trismus, joint stiffness, pain, and sores. When the onset is first felt, immediately take Cong Bai (Scallion White), Xiang Chi (Fermented Soybean), and Gan Cao (Licorice Root) decoction. If sores appear on the body upon onset, take Maidong (Ophiopogon Tuber), Renshen (Ginseng Root), Gan Cao (Licorice Root), Guixin (Cinnamon Heart), Cong Bai (Scallion White), and Xiang Chi (Fermented Soybean).
Fuzi (Prepared Aconite Root) opposes Baishiyin (White Quartz) and also opposes Shizhizhi (Red Halloysite). Upon Fuzi onset, it causes vomiting, regurgitation, leg pain, body stiffness, joint pain, and facial swelling. Taking alcohol and eating hot noodles upon onset leads to self-healing. This is the same resolution as for Baishiyin.
Upon onset of Shizhizhi (Red Halloysite) or Zishiyin (Purple Quartz), drinking alcohol is appropriate; resolution is achieved through alcohol. For any drug opposition onset, some may require hot wine; this cannot be generalized.
The above eight rules for rescuing drug oppositions are from *Qianjin Fang* (Essential Prescriptions Worth a Thousand Gold).
Sun Guxiu, Grand Tutor of Jin, mistakenly ingested Fusuo Dansha (Volatile Cinnabar processed in a furnace), resulting in poisoning. He earnestly sought treatment from Shiwan (Zhang Lu's pseudonym). Examination revealed his constitution was originally deficient, and recently due to deficiency fire flaming upward, he experienced dysphagia and swelling extending to both cheeks. The physician had used bitter-cold herbs to clear heat excessively, causing spiritual unrest. Each dose of medication included five qian of Dansha (Cinnabar). After just one dose, he felt an object touching inside his chest several times. The next morning, the medical officer examined him and inspected the Dansha again, noting its black and dull color, identifying it as Fusuo Dansha from the cinnabar furnace. The doctor ordered the Dansha to be replaced and administered four more doses. Day and night, he was restless and irritable. In the evening, he shivered with aversion to cold; his head and face were hot with profuse sweating; his calves and knees were cold as ice; suddenly his qi rebelled upward nearly to cessation. The doctor stared blankly, at a loss. Thus, Shiwan was invited to diagnose. The six pulses were choppy, rapid, and indistinct. Inspection of lips and tongue showed colors like mud, swollen, thick, damp, and slippery. If this were extreme heat mimicking Yin, there would certainly be no dampness and slipperiness. If this were cold invading the Three Yin meridians, there would certainly be no abnormal thickness and dampness. Only internal accumulation of wine and food presents such moldy-soy-sauce color. Examining his urination and defecation as regulated, and chest/abdomen as soft, it was determined there was no excess stagnation in the Stomach Fu organ. Although the syndrome was critical and doubtful, the patient's plea for help was most urgent. Combining pulse and syndrome, it was indeed Yin suffering from heat constraint. The most urgent concern now was fear of panting and sweating leading to collapse. Reluctantly, Shengmai San (Generate the Pulse Powder) and Liuwei Dihuang Wan (Six-Ingredient Rehmannia Pill) were combined. Hopefully, Metal generating Water could save the failing Lung and Kidney. After one dose, spirit calmed slightly, spontaneous sweating reduced. After another dose, consciousness returned slightly, thin gruel could be taken, allowing him to briefly describe his previous illness and prescribed formulas, without yet mentioning the Fusuo Dansha. Seeing his tongue edges slightly turning red, while qi remained weak and feet cold as before, Guixin (Cinnamon Heart) 5 fen and Wuweizi (Schisandra Berry) several grains were added to the previous formula. After taking, feet became slightly warm, qi connected slightly, speech gained order. Only then did he detail the error of ingesting Fusuo Dansha. Therefore, from the previous formula, Dihuang (Rehmannia Root), Guixin (Cinnamon Heart), and Wuweizi (Schisandra Berry) were removed, and Zaoren (Ziziphus Seed), Qiushi (Urine Sediment), and Renzhonghuang (Human Waste Charcoal) were substituted to specifically detoxify Cinnabar. After three doses, the tongue turned slightly red. Although not yet fresh and clean, the volatile toxin gradually resolved. Because the two Chi pulses were wiry and fine, Renzhonghuang (Human Waste Charcoal) was removed, and Dihuang (Rehmannia Root) was used again to tonify the Lower Yuan. Over several days, sometimes Renzhonghuang was removed for Dihuang, sometimes Dihuang for Renzhonghuang, alternating based on pulse and syndrome. These two substances were not used together because it was feared that Renzhonghuang's sweet taste would linger in the Diaphragm, carrying Dihuang's cloying nature, preventing rapid arrival in the Lower Jiao. Although the Lower Yuan was deficient, in tonic medications, Lurong (Deer Antler) and Heche (Placenta) were preferred over Guizhi (Cinnamon Twig) and Fuzi (Prepared Aconite Root) out of concern that they might stimulate the residual violence of the Cinnabar.