（内经至真要大论所列病机，凡言火者五，言热者四，似皆谓之火也。然诸病之见于诸
篇者
悉病
于篇
为真
之不
甚则
之元
病在
为病
急烈
又何难哉。惟虚
病为最者，正以
大肠之火。山栀
此不可。黄芩清
之火，善除骨蒸
梨汁贝母，解上
清肝肾大肠之火
泻诸经之浮火，元
胡黄连，泻五脏之
火，泽泻车前子，
泻阳明诸经实热
滋心肾不交，
已若尽之。然
（相传此方为太仓公火剂，而崔氏治刘护军，又云其自制者。） 治一切火热，表
盛，狂躁烦心。（邪入于阳则狂，心为热所扰则烦，躁则烦之甚也。）口燥咽干。（火盛
大热干呕。（热毒上逆。）错语不眠。（热昏其神，崔尚书曰∶胃有燥屎，令人错语。
亦令人错语。若秘而错语者，宜承气汤。通而错语者，宜黄连解毒汤。）吐血衄血。（
衄血者，当汗不汗，蕴热逼血上行也。）热甚发斑。（热毒入胃。）
黄连 黄芩 黄柏 栀子 等分。
三焦积热，邪火妄行，故用黄芩泻肺火于上焦，黄连泻脾火于中焦。（王海藏曰∶黄连
泻心
膀胱
也。
微热
三下
湿热
水丸，名三黄金花丸。治中外诸热，寝汗切牙，梦语惊悸。吐衄淋秘，劳嗽骨蒸。加大
黄名
粥丸
火生
气
（
汗
阳
连
（
丹
受
则血归经而自安矣。寇宗 曰∶以苦泄其热，就以苦补其心，盖一举而两得之。吴鹤皋曰∶
治病必求其本。阳毒上窍出血，则热为本，血为标。能去其热，则血不治而自归经矣。李士
材曰∶古人用大黄治虚劳吐血，意甚深微。盖浊阴不降，则清阳不升。瘀血不去，则新血不
生也。杨仁斋曰∶血遇热则宣流，故止血多用凉药。然亦有气虚挟寒，营气虚散，血亦错行，
所谓阳虚阴必走是已。法当温中，使血自归经，宜理中汤加木香，七气汤加川芎，或甘草
干姜汤，甚效。）又大黄用酒浸，蒸晒九次，蜜丸，名三黄丸。治三焦积热，头项肿痛，目
赤口疮，心膈烦躁，大便秘结，小便赤涩，及消渴羸瘦，（消渴羸瘦，由于火炎水干。）
《内经·至真要大论》中列出的病机，凡是提到“火”的有五种，提到“热”的有四种，似乎都指的是火邪。然而各种疾病在诸篇中记载的情况，其危急猛烈程度各不相同，其中虚损导致的疾病最为严重。这其中的道理并不深奥难懂。
（相传此方源自太仓公的火剂，崔氏用于治疗刘护军，又说是他自制的。）本方主治一切火热证，表现为表热盛、狂躁、心烦。（邪气侵入阳分则发狂，心被热邪扰乱则生烦，躁是烦的加重表现。）口燥咽干。（火邪亢盛导致津液干燥。）大热、干呕。（热毒上逆所致。）胡言乱语、失眠。（热邪使神志昏蒙。崔尚书说：胃中有燥屎，会导致胡言乱语。）也有导致胡言乱语的情况。如果便秘且胡言乱语的，适宜用承气汤；如果通畅却胡言乱语的，适宜用黄连解毒汤。）吐血、鼻衄。（衄血是因为应当发汗而未发汗，蕴积的热邪逼迫血液上行所致。）热势极盛出现发斑。（热毒入胃所致。）
三焦积聚热邪，邪火妄行，所以用黄芩清泻上焦肺火，黄连清泻中焦脾火。（王海藏说：黄连……膀胱……微热……三下……湿热……制成水丸，名为三黄金花丸。治疗内外各种热证，夜间盗汗、磨牙、梦中言语、惊悸。吐血、鼻衄、淋证、便秘，虚劳咳嗽、骨蒸潮热。加入大黄名为……粥丸……火生……气……（……汗……阳……连……（丹……受……则血归经而自然安宁了。寇宗奭说：用苦味药泄热，同时也用苦味药补心，这是一举两得的方法。吴鹤皋说：治病必须探究根本。阳毒导致上窍出血，热是本，血是标。能去除热邪，血不治疗也会自然回归经脉。李士材说：古人用大黄治疗虚劳吐血，用意非常深远微妙。因为浊阴不下降，清阳就无法上升。瘀血不去除，新血就无法生成。杨仁斋说：血液遇到热就会散乱流动，所以止血多用凉药。然而也有气虚挟带寒邪，营气虚弱散乱，血液也会错乱运行，这就是所谓的“阳虚阴必走”。治法应当温中，使血液自然回归经脉，适宜用理中汤加木香，七气汤加川芎，或甘草干姜汤，效果很好。）另外，大黄用酒浸泡，蒸晒九次，制成蜜丸，名为三黄丸。主治三焦积聚热邪，头项肿痛，眼睛红赤、口舌生疮，心胸膈部烦躁，大便秘结，小便短赤涩痛，以及消渴症、身体消瘦。（消渴和身体消瘦，是由于火炎上灼、肾水干枯所致。）
The *Neijing* (Classic of Internal Medicine), in the chapter "Zhi Zhen Yao Da Lun" (Great Treatise on the Most Essential Principles), lists pathogenesis mechanisms; those mentioning "Fire" number five, and those mentioning "Heat" number four, seemingly all referring to Fire pathogens. However, the severity and urgency of various diseases recorded in different chapters vary significantly, with diseases arising from deficiency being the most critical. The rationale behind this is not difficult to understand.
(It is said that this prescription originated as a fire-clearing agent from Tai Cang Gong, used by Cui Shi to treat Commander Liu Hu, and was also claimed to be his own creation.) It treats all types of Fire-Heat conditions, characterized by exterior heat excess, mania, restlessness, and vexation. (When pathogenic factors enter the Yang aspect, mania occurs; when the Heart is disturbed by Heat, vexation arises; restlessness is an intensification of vexation.) Dry mouth and throat. (Excessive Fire consumes body fluids.) High fever and dry retching. (Rebellious upward movement of Heat toxins.) Incoherent speech and insomnia. (Heat confounds the Spirit. Minister Cui stated: Dry feces in the Stomach can cause incoherent speech.) This can also lead to incoherent speech. If incoherent speech accompanies constipation, Chengqi Tang (Gut-Purging Decoction) is appropriate; if it occurs despite normal bowel movements, Huanglian Jiedu Tang (Coptis Decoction for Resolving Toxicity) is appropriate.) Hematemesis (vomiting blood) and epistaxis (nosebleed). Epistaxis occurs when sweating should have been induced but was not, causing accumulated Heat to force blood upward.) Heat rash (erythema) due to extreme heat. (Heat toxins entering the Stomach.)
Huanglian (Rhizoma Coptidis), Huangqin (Radix Scutellariae), Huangbai (Cortex Phellodendri), Zhizi (Fructus Gardeniae), in equal proportions.
Accumulation of Heat in the Triple Burner causes Evil Fire to act recklessly. Therefore, Huangqin is used to clear Lung Fire in the Upper Burner, and Huanglian to clear Spleen Fire in the Middle Burner. (Wang Haizang stated: Huanglian... Bladder... slight heat... three times... damp-heat... made into water pills, named Sanhuang Jinhua Wan (Three-Yellow Flower Pill). It treats various internal and external heat syndromes, night sweats, teeth grinding, somniloquy, and palpitations with fright. Hematemesis, epistaxis, stranguria, and constipation, consumptive cough, and bone-steaming fever. Adding Dahuang (Radix et Rhizoma Rhei) creates... porridge pills... fire generates... qi... ( ...sweat ...Yang ...Lian ...Dan ...receive ...then blood returns to its vessels and settles naturally. Kou Zongshi stated: Using bitter substances to drain heat simultaneously nourishes the Heart with bitterness, achieving two goals with one action. Wu Hegao stated: Treating disease requires seeking its root. When Yang toxicity causes bleeding from upper orifices, Heat is the root, and blood loss is the branch. Removing the Heat allows the blood to return to its vessels without specific hemostatic treatment. Li Shicai stated: The ancients' use of Dahuang to treat hematemesis due to consumption is profound. Because if turbid Yin does not descend, clear Yang cannot ascend. If stasis blood is not expelled, new blood cannot generate. Yang Renzhai stated: Blood flows chaotically when exposed to Heat, so cooling herbs are commonly used for hemostasis. However, there are cases of Qi deficiency with Cold, or deficient and scattered Ying-Qi, where blood also moves erratically, known as 'when Yang is deficient, Yin must leak.' The method should be to warm the Middle to allow blood to return to its vessels naturally. Lizhong Tang (Regulate the Middle Decoction) with Muxiang (Radix Aucklandiae) or Qi Qi Tang (Seven-Air Decoction) with Chuanxiong (Rhizoma Chuanxiong), or Gancao Ganjiang Tang (Licorice and Dried Ginger Decoction) are very effective.) Additionally, Dahuang soaked in wine, steamed and sun-dried nine times, formed into honey pills, is named Sanhuang Wan (Three-Yellow Pill). It treats accumulation of Heat in the Triple Burner, swelling and pain of the head and neck, red eyes, oral ulcers, irritability in the chest and diaphragm, constipation, scanty and painful urination, as well as Xiao Ke (Wasting-Thirst syndrome) and emaciation. (Xiao Ke and emaciation result from blazing Fire drying up Kidney Water.)