地骨皮 子主治。清肺肝。润肺补肾。益精治五劳七伤。消渴。消中。经络虚痛。周痹
风湿。 皮主治。凉血。补血。泻肾火。降肺中伏火。去胞中火。坚筋骨。治风邪在表。
风湿。脾痛虚劳自汗骨蒸。咳嗽。吐血。骨槽风。金疮。四神丸。甘枸杞一斤。好酒浸作四
分。四两用蜀椒一两炒。四两用茴香一两炒。四两用脂麻一两炒。四两用川楝肉一两炒。拣
出枸杞。加熟地白术白茯苓各一两。研末。蜜丸梧子大。空腹温酒下三十丸。治肾虚目昏。
或云翳遮睛。 枸杞丸。枸杞子黄精各等分。研末。蜜丸梧子大。每服五十丸。空腹温酒下
。补精气。 枸杞酒。枸杞子生地浸酒服。除冷风。壮阳道。治虚弱目泪。 地骨皮丸。地
骨皮黄 桑白皮。山栀子马兜铃各等分。研末。甘草膏和丸芡实大。每服一丸。噙化。治肺
脏壅热口臭粘腻。 又方。地骨皮紫参黄 大黄（微炒）郁李仁（微炒）各五钱。龙胆黄芩
枳壳
（麸炒）木香猪苓海蛤（细研）各一分。研末。蜜丸绿豆大。每服五丸。治脊疳。 地骨皮
散。
地骨皮知母炙草半夏柴胡人参赤茯苓各等分。研末。每服二钱。水煎加生姜服。治虚热作渴
。伤寒壮热余热。 又方。地骨皮柴胡各一两。桑白皮（炒）枳壳（麸炒）前胡黄 （炒）
各七钱
五分。白茯苓五加皮人参甘草桂心白芍各五钱。 咀。每服三五钱。加生姜水煎服。治妇人
血风。气体虚弱。寒热发渴。或晡热内热。 地骨皮汤。地骨皮生地麦冬黄 山药五味子淡
竹叶。水煎服。治心虚热。 又方。四物汤加地骨皮丹皮各三钱。治阴虚火旺。骨蒸发热。
日静夜剧。妇人热入血室。胎前发热。
地骨皮与枸杞子主治相同。能清泄肺、肝二经之热，润肺并补肾精，填补精髓，治疗五劳七伤，缓解消渴（糖尿病样症状）、消中（多食易饥），以及经络虚痛、周身痹证、风湿疼痛。
地骨皮单独主治：凉血，补血，泻肾中相火，降肺中伏火，清除胞宫之火，坚固筋骨，治疗风邪在表、风湿痹痛、脾脏疼痛、虚劳自汗、骨蒸潮热、咳嗽、吐血、骨槽风、金疮等症。
四神丸方：取甘枸杞一斤，用优质酒浸泡，分为四份；蜀椒一两炒制，取四分之一量；小茴香一两炒制，取四分之一量；脂麻（黑芝麻）一两炒制，取四分之一量；川楝肉一两炒制，取四分之一量。拣出上述药材后，加入熟地黄、白术、白茯苓各一两，研为细末，用蜂蜜制成梧桐子大小的丸剂。空腹时以温酒送服三十丸。用于治疗肾虚导致的视力昏花，或云翳遮蔽瞳孔。
枸杞丸方：枸杞子、黄精各等分，研为细末，用蜂蜜制成梧桐子大小的丸剂。每次服用五十丸，空腹时以温酒送服。用于补益精气。
枸杞酒方：用枸杞子、生地黄浸泡于酒中饮用。可祛除冷风，壮阳道，治疗虚弱引起的目泪不止。
地骨皮丸方：地骨皮、黄芩、桑白皮、山栀子、马兜铃各等分，研为细末，用甘草膏调和，制成芡实大小的丸剂。每次服用一丸，含化咽下。用于治疗肺脏壅滞发热导致的口臭、口粘腻。
又一方：地骨皮、紫参、黄芩、大黄（微炒）、郁李仁（微炒）各五钱；龙胆草、黄芩、枳壳（麸炒）、木香、猪苓、海蛤（细研）各一分。研为细末，用蜂蜜制成绿豆大小的丸剂。每次服用五丸。用于治疗脊疳。
地骨皮散方：地骨皮、知母、炙甘草、半夏、柴胡、人参、赤茯苓各等分，研为细末。每次服用二钱，加水煎煮，加入生姜同服。用于治疗虚热作渴、伤寒高热后的余热未清。
又一方：地骨皮、柴胡各一两；桑白皮（炒）、枳壳（麸炒）、前胡、黄芩（炒）各七钱五分；白茯苓、五加皮、人参、甘草、桂心、白芍各五钱。切碎。每次服用三至五钱，加生姜水煎服。用于治疗妇人血风病，体质虚弱，寒热往来且口渴，或午后及夜间内热。
Diguopi (Cortex Lycii) and Gouqizi (Fructus Lycii) share the same indications. They clear heat from the Lung and Liver meridians, moisten the Lungs and tonify Kidney essence, replenish Jing (Essence), treat Wu Lao Qi Shang (Five Exhaustions and Seven Injuries), alleviate Xiaoke (Wasting-Thirst, similar to diabetes), Xiaozhong (Excessive Hunger), deficiency pain in collaterals and meridians, generalized Bi syndrome (painful obstruction), and wind-dampness pain.
Individually, Diguopi (Cortex Lycii) cools blood, nourishes blood, drains ministerial fire from the Kidney, descends latent fire in the Lungs, clears fire from the uterus, strengthens sinews and bones, treats exterior wind-pathogens, wind-dampness bi-syndrome, spleen pain, deficiency consumption with spontaneous sweating, bone-steaming tidal fever, cough, hemoptysis, gucao feng (bone groove wind, likely referring to osteomyelitis or severe dental/jaw infection), and traumatic injuries.
Sishen Wan (Four Spirits Pill): Take one jin of Gan Gouqi (Sweet Fructus Lycii), soak it in good-quality wine, and divide into four parts. Take one part of Sichuan pepper (Shu Jiao, 1 liang stir-fried), one part of fennel (Huixiang, 1 liang stir-fried), one part of sesame seeds (Zhima, 1 liang stir-fried), and one part of Toosendan fruit (Chuanlian Rou, 1 liang stir-fried). After selecting these ingredients, add Shudi Huangjing (Prepared Rhizoma Rehmanniae), Baizhu (Rhizoma Atractylodis Macrocephalae), and Baifuling (Poria with White Wood, each 1 liang). Grind into fine powder, mix with honey to form pills the size of mulberry seeds. Take thirty pills on an empty stomach with warm wine. Treats blurred vision due to Kidney deficiency or cloudiness obscuring the pupil.
Gouqi Wan (Lycium Pill): Equal parts of Gouqizi (Fructus Lycii) and Huangjing (Rhizoma Polygonati). Grind into fine powder, mix with honey to form pills the size of mulberry seeds. Take fifty pills per dose on an empty stomach with warm wine. Tonifies Jing and Qi.
Gouqi Jiu (Lycium Wine): Soak Gouqizi (Fructus Lycii) and Shengdihuang (Raw Rhizoma Rehmanniae) in wine and drink. Expels cold wind, strengthens Yang function, and treats excessive tearing of eyes due to weakness.
Diguopi Wan (Cortex Lycii Pill): Equal parts of Diguopi (Cortex Lycii), Huangqin (Radix Scutellariae), Sangbaipi (Cortex Mori), Shanzhizi (Fructus Gardeniae), and Madouling (Flos Aristolochiae). Grind into fine powder, bind with licorice paste to form pills the size of Euryale seeds. Take one pill per dose, holding it in the mouth to dissolve slowly. Treats halitosis and sticky mouth sensation caused by lung heat accumulation.
Another prescription: Diguopi (Cortex Lycii), Zican (Radix Lithospermi), Huangqin (Radix Scutellariae), Dahuang (Radix et Rhizoma Rhei, lightly stir-fried), Yuliren (Semen Pruni, lightly stir-fried), each 5 qian; Longdan Cao (Radix Gentianae), Huangqin (Radix Scutellariae), Zhike (Fructus Aurantii, bran-stir-fried), Muxiang (Radix Aucklandiae), Zhuling (Polyporus), Hai Ge (Concha Meretricis, finely ground), each 1 fen. Grind into fine powder, mix with honey to form pills the size of mung beans. Take five pills per dose. Treats Ji Gan (spinal malnutrition/abscess).
Diguopi San (Cortex Lycii Powder): Equal parts of Diguopi (Cortex Lycii), Zhimu (Rhizoma Anemarrhenae), Zhi Gancao (Prepared Radix Glycyrrhizae), Banxia (Rhizoma Pinelliae), Chaihu (Radix Bupleuri), Renshen (Radix Ginseng), and Chifuling (Poria with Red Wood). Grind into fine powder. Take 2 qian per dose, decoct in water with fresh ginger. Treats thirst due to deficiency heat, and residual heat after high fever in Shanghan (Cold Damage).
Another prescription: Diguopi (Cortex Lycii) and Chaihu (Radix Bupleuri), each 1 liang; Sangbaipi (Cortex Mori, stir-fried), Zhike (Fructus Aurantii, bran-stir-fried), Qianhu (Radix Peucedani), Huangqin (Radix Scutellariae, stir-fried), each 7 qian 5 fen; Baifuling (Poria with White Wood), Wujia Pi (Cortex Acanthopanacis), Renshen (Radix Ginseng), Gancao (Radix Glycyrrhizae), Guixin (Ramulus Cinnamomi), and Baishao (Radix Paeoniae Alba), each 5 qian. Cut into small pieces. Take 3-5 qian per dose, decoct in water with fresh ginger. Treats Xuefeng (Blood Wind) in women, characterized by weak constitution, alternating chills and fever with thirst, or afternoon/evening internal heat.
Diguopi Tang (Cortex Lycii Decoction): Diguopi (Cortex Lycii), Shengdihuang (Raw Rhizoma Rehmanniae), Maidong (Radix Ophiopogonis), Huangqin (Radix Scutellariae), Shanyao (Rhizoma Dioscoreae), Wuweizi (Fructus Schisandrae), and Danzhuyè (Herba Lophatheri). Decoct in water and drink. Treats Heart deficiency heat.
Another prescription: Siwu Tang (Four Substances Decoction) plus Diguopi (Cortex Lycii) and Danpi (Cortex Moutan), each 3 qian. Treats Yin deficiency with hyperactive fire, bone-steaming fever (worse at night than during the day), Heat entering the Blood Chamber in women, and fever before childbirth.