徐仲光治一痘，发热，时衄血，宜发之，用升麻葛根汤加荆、蒡而愈。
一痘四朝吐血，痘陷淡白，烦躁，谵语妄言，肢冷身凉。此血热毒壅未尽，即服凉药攻伐之故，今血脱毒
解而虚矣。宜先益气，保元汤加姜、附、芎、归、蝉、芍、糯米而愈。
一痘正起发而便血，怠惰减食，作渴肢冷，此皆脾虚也，四君子汤加升、橘、炮姜而愈。
一痘八日，根窠赤肿胀满痛，烦渴饮冷，便下黑血，此热毒内蕴也，犀角地黄汤治愈。
一痘收靥身热，咳嗽血痰，声哑鼻衄，此火刑肺金，黄连解毒汤加麦冬、犀角、丹皮、知母、牛蒡而愈。
一痘靥后，咳嗽不已，此毒郁于肺，清金开郁解毒而愈。
一痘靥后，便下紫血，此毒郁滞下，郁金五钱，牛蒡一钱，每服五分，灯心汤下。
一痘后溏泄，粪后下血，此脾弱也，用异功散加升麻、地榆、黄连、小柴胡汤而愈。
一痘后血淋，乃热结下焦也，柏、知、通、地、小蓟根、藕节、归、滑、甘草梢、竹叶，服愈。
一女六岁，标点，吐紫黑血甚多，然而唇舌滋润，形色俱顺，神宁气旺，竟无恙。因女之父素有血症，乃
遗禀，非毒也，故不解毒，不补脾而收功。症虽险，而症与神自顺也，未可以见点吐血紫黑为死也。
万密斋曰∶里中林霄，年二十余染痘，初发热，小便下血。予闻之曰∶不可为矣。或问故。曰∶乙未春，
祁水桃村坳徐氏，出痘死者十八人，皆小便血也。霄越三月殒。
徐仲光治疗一例痘疮患者，出现发热、时常鼻出血的症状，适宜采用发汗解表的方法，使用升麻葛根汤（Shengma Gegen Tang）加入荆芥（Jingjie, Schizonepetae Herba）、牛蒡子（Niubangzi, Arctii Fructus）而痊愈。
另一例痘疮发病第四天吐血，痘疹凹陷且颜色淡白，伴有烦躁不安、胡言乱语、四肢冰冷、身体发凉。这是血热毒邪壅盛未尽，又因服用寒凉药物攻伐损伤正气所致，如今血液耗脱、毒邪虽解但人体已虚。适宜先益气固本，使用保元汤（Baoyuan Tang）加入干姜（Ganjiang, Zingiberis Rhizoma）、附子（Fuzi, Aconiti Lateralis Radix Praeparata）、川芎（Chuanxiong, Chuanxiong Rhizoma）、当归（Danggui, Angelicae Sinensis Radix）、蝉蜕（Chantui, Cicadae Periostracum）、白芍（Baishao, Paeoniae Radix Alba）、糯米（Nuomi, Oryzae Sativae Germen）而痊愈。
又一例痘疮正在起发阶段却出现便血，精神倦怠、食欲减退、口渴、四肢发冷，这些都是脾虚的表现，使用四君子汤（Sijunzi Tang）加入升麻（Shengma, Cimicifugae Rhizoma）、陈皮（Chenpi, Citri Reticulatae Pericarpium）、炮姜（Paojiang, Zingiberis Rhizoma Preparatum）而痊愈。
又一例痘疮第八天，痘疹根部红赤肿胀、胀满疼痛，心烦口渴喜饮冷水，大便排出黑色血液，这是热毒内蕴所致，使用犀角地黄汤（Xijiao Dihuang Tang）治愈。
又一例痘疮收靥（结痂脱落）后身体发热，咳嗽且有血痰，声音嘶哑、鼻出血，这是火邪刑克肺金（Fire insulting Metal of the Lung），使用黄连解毒汤（Huanglian Jiedu Tang）加入麦冬（Maidong, Ophiopogonis Radix）、犀角（Xijiao, Rhinocerotis Cornu，现多用水牛角替代）、牡丹皮（Danpi, Moutan Cortex）、知母（Zhimu, Anemarrhenae Rhizoma）、牛蒡子（Niubangzi, Arctii Fructus）而痊愈。
又一例痘疮结痂后，咳嗽不止，这是毒邪郁结于肺，通过清金润肺、开郁解毒的方法而痊愈。
又一例痘疮结痂后，大便排出紫色血液，这是毒邪郁滞于下焦，使用郁金（Yujin, Curcumae Radix）五钱、牛蒡子一钱，每次服用五分，用灯心草汤（Dengxincao Decoction）送服。
又一例痘疮后出现溏泄（稀便），排便后下血，这是脾气虚弱所致，使用异功散（Yigong San）加入升麻、地榆（Diyu, Sanguisorbae Radix）、黄连（Huanglian, Coptidis Rhizoma），并配合小柴胡汤（Xiaochaihu Tang）而痊愈。
又一例痘疮后出现血淋（小便涩痛带血），这是热邪结聚于下焦，使用黄柏（Bai, Phellodendri Cortex）、知母、木通（Tong, Akebiae Caulis）、生地黄（Di, Rehmanniae Radix）、小蓟根（Xiaoji Gen, Cirsii Japonici Radix）、藕节（Oujie, Nelumbinis Rhizomatis Nodus）、当归、滑石（Hua, Talcum）、甘草梢（Gancao Shao, Glycyrrhizae Radix et Rhizoma）、竹叶（Zhuye, Bambulae Folium），服药后痊愈。
一女六岁，出痘点发出时，呕吐大量紫黑色血液，然而其唇舌滋润，神色形态均顺，神志安宁、气息旺盛，最终安然无恙。因为该女之父素有血症病史，此为先天遗传禀赋，并非痘毒所致，所以不采用解毒或补脾的方法，而是顺应病情自然收功。症状虽然看似危险，但症候与神气自相顺遂，不能一见出痘点发出时呕吐紫黑血就断定为死证。
万密斋说：乡里林霄，二十多岁感染痘疮，起初发热，小便下血。我听说后说：无法救治了。有人问原因。我说：乙未年春天，祁水桃村坳徐家，出痘死亡的有十八人，都是小便出血。林霄过了三个月也去世了。
Xu Zhongguang treated a case of smallpox where the patient presented with fever and occasional epistaxis (nosebleed). The appropriate treatment was to induce sweating to release the exterior. He used Shengma Gegen Tang (Cimicifuga and Kudzu Root Decoction) added with Jingjie (Schizonepetae Herba) and Niubangzi (Arctii Fructus), resulting in recovery.
In another case, a smallpox patient vomited blood on the fourth day of eruption. The pustules were depressed and pale, accompanied by restlessness, delirious speech, cold limbs, and a cool body. This indicated that the heat-toxin in the blood was not yet fully resolved, but had been further damaged by the administration of cooling and purgative medicines. Now, with blood depletion and toxin resolution, the patient was deficient. The priority was to tonify Qi. He used Baoyuan Tang (Preserve Vitality Decoction) added with Ganjiang (Prepared Zingiberis Rhizoma), Fuzi (Prepared Aconiti Lateralis Radix), Chuanxiong (Chuanxiong Rhizoma), Danggui (Angelicae Sinensis Radix), Chantui (Cicadae Periostracum), Baishao (Paeoniae Radix Alba), and Nuomi (Oryzae Sativae Germen), leading to recovery.
In a third case, a patient experienced hematochezia (blood in stool) while the smallpox was erupting. Symptoms included lethargy, reduced appetite, thirst, and cold limbs, all indicative of Spleen deficiency. He used Sijunzi Tang (Four Gentlemen Decoction) added with Shengma (Cimicifugae Rhizoma), Chenpi (Citri Reticulatae Pericarpium), and Paojiang (Prepared Zingiberis Rhizoma), resulting in recovery.
In a fourth case, on the eighth day of smallpox, the base of the lesions was red, swollen, full, and painful. The patient was vexed, thirsty, desired cold drinks, and passed black blood in the stool. This was due to internal accumulation of heat-toxin. He used Xijiao Dihuang Tang (Rhinoceros Horn and Rehmannia Decoction) to cure it.
In a fifth case, after the crusting phase of smallpox, the patient had fever, cough with bloody sputum, hoarseness, and epistaxis. This was attributed to Fire insulting the Metal of the Lung. He used Huanglian Jiedu Tang (Coptis Decoction for Resolving Toxins) added with Maidong (Ophiopogonis Radix), Xijiao (Rhinocerotis Cornu, now commonly substituted with Buffalo Horn), Danpi (Moutan Cortex), Zhimu (Anemarrhenae Rhizoma), and Niubangzi (Arctii Fructus), leading to recovery.
In a sixth case, after the crusting phase, the patient suffered from persistent cough. This was due to toxin stagnation in the Lung. Treatment focused on clearing the Lung, resolving stagnation, and detoxifying, resulting in recovery.
In a seventh case, after the crusting phase, the patient passed purple blood in the stool. This indicated toxin stagnation in the lower jiao. He prescribed Yujin (Curcumae Radix) 5 qian and Niubangzi (Arctii Fructus) 1 qian, taken as 0.5 qian per dose, administered with Dengxincao Tang (Juncus Decoction).
In an eighth case, following smallpox, the patient experienced loose stools and hematochezia after defecation. This was due to weak Spleen Qi. He used Yigong San (Extraordinary Power Powder) added with Shengma (Cimicifugae Rhizoma), Diyü (Sanguisorbae Radix), Huanglian (Coptidis Rhizoma), combined with Xiaochaihu Tang (Minor Bupleurum Decoction), resulting in recovery.
In a ninth case, post-smallpox hematuria with dysuria (blood strangury) occurred. This was due to heat binding in the lower jiao. He used Bai (Phellodendri Cortex), Zhimu (Anemarrhenae Rhizoma), Tong (Akebiae Caulis), Di (Rehmanniae Radix), Xiaoji Gen (Cirsii Japonici Radix), Oujie (Nelumbinis Rhizomatis Nodus), Danggui (Angelicae Sinensis Radix), Hua (Talcum), Gancao Shao (Tip of Glycyrrhizae Radix et Rhizoma), and Zhuye (Bambulae Folium). The patient recovered after taking the medicine.
A six-year-old girl presented with vomiting of large amounts of dark purple-black blood during the eruption of smallpox points. However, her lips and tongue were moist, her complexion and demeanor were favorable, her spirit was calm, and her qi was vigorous. She ultimately remained unharmed. Since her father had a history of blood disorders, this was considered a congenital predisposition rather than toxic pathogenic factor. Therefore, no detoxification or Spleen-tonifying measures were taken, and the condition resolved naturally. Although the symptoms appeared dangerous, the clinical presentation and spirit were harmonious; one cannot deem the vomiting of dark purple-black blood during smallpox eruption as a fatal sign.
Wan Mizhai stated: Lin Xiao from my village, in his early twenties, contracted smallpox. Initially presenting with fever, he also had blood in his urine. Upon hearing this, I said, "It is incurable." When asked why, I replied: "In the spring of the Yiwei year, eighteen people from the Xu family in Taocun'ao, Qishui, died of smallpox, all presenting with blood in the urine. Lin Xiao died three months later."