2001年5月26日，患者因"停经3月，下腹胀痛3月"入住嘉兴市妇幼保健院，住院号：0044831。彩超检查示：子宫多发肌瘤，双侧附件实质不均质包块腹水。穿刺腹水涂片找到癌细胞。诊断：卵巢癌三期，子宫肌瘤，子宫内膜息肉。于6月2日行手术时，见肝表面有黄豆大结节。6月6日第一次化疗。2001年8月13日，患者行第二次减瘤术，送检淋巴结中，左闭孔0/3、左股深0/3、左髂外4/6、左髂窝1/1、右髂窝2/8、右髂外3/5、右股深1/4，共11只淋巴结转移。28日行第四次化疗。2001年11月14日第六次化疗后，白细胞3.1×10九次方/升，形神俱乏，患者坚决要求出院。同年12月5日，来我处请求中药治疗。
卵巢肿瘤是妇科常见肿瘤，三分之二以上的恶性肿瘤见于40-65岁。由于卵巢肿瘤深藏于盆腔，早期无症状，又缺乏较好的早期诊断及鉴别方法，以致确诊时大多数患者已到晚期。5年生存率不到四分之一，死亡率超过宫颈癌与宫体癌之和，为妇科肿瘤中威胁最大的疾患。卵巢肿瘤，中医学早有记载，《灵枢-水胀》篇云："寒先客于肠外，与卫气相搏，气不得营，因有所系癖而内著恶气乃超，癔肉乃生，其始生也，大如鸡卵，稍以益大，至其成，如杯子之状。久者离实，按之则坚------"。属祖国医学"症瘕""积聚"等范畴。本案患者入住嘉兴市妇幼保健院时，癌细胞已广泛转移，两次手术及化疗乃姑息性治疗，且身体极度虚弱，白细胞下降，无法接受继续化疗，才有求于中医药治疗。
症见：消瘦困倦，面苍神淡，心悸气短，体力不支，动则汗出，口干不思饮，纳呆，时有呕恶，脘腹胀痞，二便欠畅，舌淡红边有瘀斑，苔腻，肪沉细涩。
处方：藿香12克 茯苓12克 炒苍术12克 姜夏12克 炒三仙各12克 枳壳12克 当归12克 莪术10克每天自取活蟾蜍一只入药同煎。七帖
12月13日二诊：服药7帖，腻苔已退，湿除纳食大增，脘腹胀痞已消，二便通畅。标实已除，治当继续扶正固本，活血消癥。以生脉散加味。
处方：生晒参9克 麦冬12克 五味子10克 当归12克 莪术12克 绞股兰30克 川楝子12克 半枝莲30克 蛇舌草30克 活蟾蜍每天一只三十帖
一个月后复诊：查肝功能、血象均正常。诸症明显改善，能操持家务，唯有时觉两肩酸痛。加桑枝30克，续服。
2002年10月15日诊："服中药10个月，脸色光润，形体壮实，无任何不适，体重增加20多斤。
11月10日再次入院行放射治疗。
治疗经过：左锁骨区,左内乳区60co+10Mev电子线DT各53Gy。并又用CMF方案共化疗8次。
2002年5月28日，左乳癌术后三年半复查，CT报告：两肺多发性转移性肿癌。X线胸片诊断：左乳癌术后，两肺结节，以转移首先考虑。斤，能胜任一般劳动。B超检查示：盆腔内未探及子宫，盆腔内未见包块。盆腔内未见占位。
现代研究证实，蟾蜍提取物在体外能抑制人的卵巢腺癌细胞的呼吸；能升高白细胞，增加网状内皮系统的扶正功能，消除化疗的毒副反应，巩固化疗疗效；尚可利水消瘤，化解一切瘀郁壅滞诸疾，如积毒，积块，积胀等。蟾蜍入药配合中医辨证施治，治疗卵巢癌化疗后行之有效。
林咸桂，女性45岁，家住三门县海游镇后洋陈村。住院号：95620。门诊号：2026446。
患者于1998年10月16日入住浙江省肿瘤医院手术治疗，11月9日出院诊断：左乳单纯癌
治疗经过：术前8天予CMF方案化疗（CT×0.6d，MT×30mgd， 5FU0.75d），10月29日在全麻下行左乳癌根治术，术中清扫腋上中下三组淋巴脂肪组织，术后第五天再予CMF方案化疗，术后病理报告：:左乳疤痕乳腺内见少量低分化腺癌组织(3/11)残留，见线结异物巨细胞反应.病理分期：IIa期。
6月3日,患者再次入院。6月25日出院诊断：左乳癌术后放化疗后两肺转移。
治疗经过：患者入院后予NP方案4日一次，术后有恶心，肌肉酸痛等不适。复查血常规示：白细胞1700/立方毫米,中性粒细胞23·4%。
6月24日X线报告：肺结节灶，转移首先考虑。
住院医生在出院小结的出院情况栏写着：患者白细胞低，极易出现感染，严重者可以危及生命。
再三告诉患者家属：不能出院。患者及家属仍坚决要求出院。
患者自有难言苦衷：乳房癌已两肺转移，行化疗每打一针就要1200元，住院半月，医药费又花了15000多元。患病以来，光治疗费用已支出70000多元，身为山村一农家，再也无法凑钱继续治疗。化疗后白血球这么低，恶心呕吐，半个月米粒难进，彻夜难眠，浑身疼痛难熬，真是生不如死。至此,患者悲观绝望，不听住院医师劝阻，离开病房。当天，其丈夫找到了在浙一医院做医师的亲戚商量办法，亲戚告诉他们：等死不是办法，你们最好去找省肿瘤医院中医科陈医师，也许有救。
2002年6月26日，患者来我处求诊：身体极度消瘦虚弱，神情痛楚，面色苍白，夜寐不佳，前胸隐痛，夜间为重，偶有咳嗽，纳少呕恶，舌淡红苔腻，脉细数。
处方：二参30克 佩兰12克 猪茯苓各12克 天冬12克 牡蛎30克先煎 象贝12克 瓜蒌皮12克每天自取活蟾蜍1只，去肠入药同煎。
2002年10月15日诊：服前方三月有余，诸症缓解，能做家务，偶尔还下地劳动，唯不能持久。患者述说：癞蛤蟆实在难吃，喝时腥气上冲，呕恶，难以入咽，还会腹泻，为了求生，只有硬着头皮喝下去。服了一段日子，慢慢地也就适应了，体力渐增。这次到医院来想复查一下，看看两肺转移灶是增大了还是缩小了。
10月16日,患者拿到了X线摄片(125805号)报告，X线所见：两肺基本清晰，无明确占位，心膈无殊，X线诊断:：两肺无明确占位。
夫妻俩看了报告，见两肺转移性肿瘤经中药治疗已经消失，简直不敢相信自己的眼睛，问了身边的医生、护士，他们都说肺内肿块消失了。又马上跑来问我:陈医生，X线摄片报告说两肺转移灶消失了，这是不是真的？
再续处方,巩固疗效
处方：二参30克 夏枯草30克 牡蛎30克先煎 猪茯苓各12克熬 象贝12克 天冬12克瓜蒌皮12克每天一只活蟾蜍入药同煎。
身患重病之人在绝望时，总希望有灵丹妙药挽救自己的生命。蟾仙赐福人间，又一个乳房癌术后，放化疗后两肺转移的患者，经活蟾蜍入药治疗两肺转移灶消失了。
活蟾蜍入药治疗肺癌广泛转移
余××，女，68岁。因左侧胸痛3个月，伴咳嗽，气急，经余杭二院纤支镜检查，病理报告：右上肺小细胞癌.
CT报告:：右上肺中央型癌伴纵隔淋巴结转移。 出院诊断： 右上肺癌纵隔转移伴上腔静脉综合症。
因治疗无效于1997年9月11日来我院。证见重病容，头面浮肿，项颈粗大，颈部静脉怒张，面色暗滞，咳喘声粗，呼吸困难，脉浮数，舌紫苔黄。证属邪毒内结，气机阻遏。
治则： 解毒散结，降气化滞。 处方：
半枝莲30克，蛇舌草30克，鱼腥草30克，败酱草30克，夏枯草30克，炒苏子12克，牡蛎30克，苦参30克，米仁30克，石见穿30克，海藻12克，地龙15克，蜈蚣3枚，取活蟾蜍一只去肠入药同煎。每贴煎2汁，分4次饮服，服至10贴后症状缓解，颈静脉怒张明显消退，呼吸平稳。治疗至今已良好存活二年。
按语： 活蟾蜍入药治疗肺癌纵隔转移伴上腔静脉综合症,迅速改善了生存质量,减少痛苦延长生存期。
活蟾蜍单味治疗肺癌
张××，男，50岁。1997年10月20日因咳嗽痰多，经浙一医院活检找到癌细胞。因病人不接受治疗，迨至1998年10月来我院(门诊号167703)摄X线胸片报告：右肺周围型癌。
证见形体消瘦，面色灰黑无华，舌瘦色红苔薄黄。证属热毒瘀结于肺， 治则：清热解毒，消肿镇痛。 处方：
取活蟾蜍每天一只，去肠加黄酒少许，炖汁分三次饮服。
最初几天，服后有轻度腹痛腹泻，尔后遍身奇痒，皮肤有异物钻动，向外爬感。精神逐渐好转，食欲大增，诸症皆愈。1999年5月来院复查时判若两人，面色红润，体重增加20斤，胸片复查肿块由8×6cm，缩小至4×3 cm大小， 随访至今，已带瘤安然生存近四年。
按语：患者是五保户, 确诊肺癌而无钱医治,听天由命, 拖了一年病入膏盲，在奄奄一息之时,单味活蟾蜍有起死回生之功。
活蟾蜍入药治疗肝癌
陈××，男，
51岁，嘉善魏塘镇秀南村村民.。2000年1月29日，因胸胁胀痛两个月，经嘉善县第一人民医院检查，B超报告：肝左外叶可见23×31×30mm大小低回声区。CT片（30809号）示：肝左叶实质内可见大小约2·1×2·1CMcm低密度影，边界不清。
意见： 肝左叶癌伴肝门部淋巴结肿大；血吸虫性肝硬化， 甲胎蛋白阳性。诊断： 肝左叶原发性肝癌，当地治疗效果不佳。 5月份B超报告：肝左外叶见39×36×30mm低密度影。
当月21日,来我处就诊(门诊号2012231)，症见面色青灰，形瘦神疲，夜寐不宁，胸胁疼痛，痛如锥刺，脘腹胀痞，纳食乏味，大便干结，小便短黄，舌红苔黄，舌下脉络曲张，脉弦涩，有长期饮酒史。证属湿热蕴结，瘀血内阻。
处方：茵陈蒿汤合二参一仙汤加味：茵陈15克 生大黄5克后下 山栀12克 当归12克 二参30克 炒三仙各12克 枳壳12克 郁金12克 自取活蟾蜍1只入药同煎。服药后，诸症改善，体重渐增，能参加体力劳动，经多次B超检查，肿块略有增大，甲胎蛋白持续阳性。2001年5月B超检查报告（22852号）：肝左外叶见：81×73×47mm，低回声影。2002年4月，B超报告肝左外叶见10×9.6×5.6cm大小实质性肿块，边界尚清。甲胎蛋白阳性。已带瘤良好生存三年。
按语：肝癌患者的平均存活期很短，仅有几个月，活蟾蜍入药治疗肝癌，延长了生存期并提高了生存质量。
姜××，男，45岁。1997年8月，因右胁下疼痛，经浙二医院检查甲胎蛋白放射免疫>1000纳克/毫升，CT报告："见肝右叶有-低密度肿块阴影，累及右肾，直径约11×10cm大小。"诊断："原发性肝癌肾转移。"经当地治疗无效后来院求治（门诊号0021921）。证见口干且苦，脘胁胀痛，体倦乏力，食纳不馨，尿黄赤便秘结，触诊右胁下肿块约10×12cm大小，质硬，固定，表面高低不平。脉弦细，舌红，边有紫斑，苔薄黄。证属肝郁气滞，热毒壅盛。
处方：逍遥散合膈下逐瘀汤加减，方用柴胡10克 当归10克 杭白芍12克郁金10克 桃仁10克 川芎10克 五灵脂10克 香附10克 炙鳖甲12克 地鳖虫10克 蜂房12克 藤梨根30克 茵陈30克 虎杖30克 取活蟾蜍每天1只去肠入药同煎。服药后食欲增进，两便润肠，脘胁胀痛渐消，面色日见红润，体力增加。3个月后恢复全天工作，以后坚持原方，经5次CT复查肿块未见增大，甲胎蛋白放射免疫>1000纳克/毫升，带瘤良好生存达21个月。
按语：原发性巨块型肝癌肾转移，经活蟾蜍入药治疗延长了生存期。因摸奖得了桑塔娜轿车一辆，付清了医药费用还绰绰有余，又旧习不改，喝酒、搓麻将，"得财伤身，乐极生悲"，疲劳过度，酒精伤肝，致使疾病恶化而身亡。
蟾蜍有效剂量与中毒剂量接近，大凡疗效佳者均有毒性反应发生，尔后大多症状改善，身心轻松。蟾蜍久煎则毒性大减，每天量炖汁分次饮服亦可减轻毒性反应；初服者反应较剧，久服则逐渐适应。个体对蟾蜍剂量适应大不相同，有的每天1只小蟾蜍入煎即呕恶、难受，有的每天五只亦能接受；蟾蜍大者不良反应大，反之则小；山区比池泽的蟾蜍毒性反应大，池泽地比旱地的毒性大；蟾蜍颜色深的黑的，比颜色浅的淡的毒性反应大；蟾蜍头背颗粒大的比颗粒小的毒副反应大；夏天的比冬天的蟾蜍毒性反应大，临床应用时需不断摸索，严谨掌握有效剂量。
3, 中药煎煮、服法之宜
2001年5月26日，患者因“停经3个月，下腹胀痛3个月”入住嘉兴市妇幼保健院，住院号：0044831。彩超检查显示：子宫多发肌瘤，双侧附件实质不均质包块伴腹水。穿刺腹水涂片找到癌细胞。诊断：卵巢癌三期，子宫肌瘤，子宫内膜息肉。于6月2日行手术时，见肝表面有黄豆大小的结节。6月6日进行第一次化疗。2001年8月13日，患者行第二次减瘤术，送检淋巴结中，左闭孔0/3、左股深0/3、左髂外4/6、左髂窝1/1、右髂窝2/8、右髂外3/5、右股深1/4，共11只淋巴结转移。28日行第四次化疗。2001年11月14日第六次化疗后，白细胞计数为3.1×10^9/L，形神俱乏，患者坚决要求出院。同年12月5日，来我处请求中药治疗。
卵巢肿瘤是妇科常见肿瘤，三分之二以上的恶性肿瘤见于40-65岁。由于卵巢肿瘤深藏于盆腔，早期无症状，又缺乏较好的早期诊断及鉴别方法，以致确诊时大多数患者已到晚期。5年生存率不到四分之一，死亡率超过宫颈癌与宫体癌之和，为妇科肿瘤中威胁最大的疾患。卵巢肿瘤，中医学早有记载，《灵枢·水胀》篇云：“寒先客于肠外，与卫气相搏，气不得营，因有所系癖而内著恶气乃超，癔肉乃生，其始生也，大如鸡卵，稍以益大，至其成，如杯子之状。久者离实，按之则坚------”。属祖国医学“症瘕”、“积聚”等范畴。本案患者入住嘉兴市妇幼保健院时，癌细胞已广泛转移，两次手术及化疗乃姑息性治疗，且身体极度虚弱，白细胞下降，无法接受继续化疗，才有求于中医药治疗。
症见：消瘦困倦，面苍神淡，心悸气短，体力不支，动则汗出，口干不思饮，纳呆，时有呕恶，脘腹胀痞，二便欠畅，舌淡红边有瘀斑，苔腻，脉沉细涩。
处方：藿香12克 茯苓12克 炒苍术12克 姜夏12克 炒三仙各12克 枳壳12克 当归12克 莪术10克 每天自取活蟾蜍一只入药同煎。七帖
12月13日二诊：服药7帖，腻苔已退，湿除纳食大增，脘腹胀痞已消，二便通畅。标实已除，治当继续扶正固本，活血消癥。以生脉散加味。
处方：生晒参9克 麦冬12克 五味子10克 当归12克 莪术12克 绞股兰30克 川楝子12克 半枝莲30克 蛇舌草30克 活蟾蜍每天一只三十帖
一个月后复诊：查肝功能、血象均正常。诸症明显改善，能操持家务，唯有时觉两肩酸痛。加桑枝30克，续服。
2002年10月15日诊：“服中药10个月，脸色光润，形体壮实，无任何不适，体重增加20多斤。
11月10日再次入院行放射治疗。
治疗经过：左锁骨区,左内乳区60co+10Mev电子线DT各53Gy。并又用CMF方案共化疗8次。
2002年5月28日，左乳癌术后三年半复查，CT报告：两肺多发性转移性肿癌。X线胸片诊断：左乳癌术后，两肺结节，以转移首先考虑。斤，能胜任一般劳动。B超检查示：盆腔内未探及子宫，盆腔内未见包块。盆腔内未见占位。
现代研究证实，蟾蜍提取物在体外能抑制人的卵巢腺癌细胞的呼吸；能升高白细胞，增加网状内皮系统的扶正功能，消除化疗的毒副反应，巩固化疗疗效；尚可利水消瘤，化解一切瘀郁壅滞诸疾，如积毒，积块，积胀等。蟾蜍入药配合中医辨证施治，治疗卵巢癌化疗后行之有效。
林咸桂，女性45岁，家住三门县海游镇后洋陈村。住院号：95620。门诊号：2026446。
患者于1998年10月16日入住浙江省肿瘤医院手术治疗，11月9日出院诊断：左乳单纯癌
治疗经过：术前8天予CMF方案化疗（CT×0.6d，MT×30mgd， 5FU0.75d），10月29日在全麻下行左乳癌根治术，术中清扫腋上中下三组淋巴脂肪组织，术后第五天再予CMF方案化疗，术后病理报告：:左乳疤痕乳腺内见少量低分化腺癌组织(3/11)残留，见线结异物巨细胞反应.病理分期：IIa期。
6月3日,患者再次入院。6月25日出院诊断：左乳癌术后放化疗后两肺转移。
治疗经过：患者入院后予NP方案4日一次，术后有恶心，肌肉酸痛等不适。复查血常规示：白细胞1700/立方毫米,中性粒细胞23·4%。
6月24日X线报告：肺结节灶，转移首先考虑。
住院医生在出院小结的出院情况栏写着：患者白细胞低，极易出现感染，严重者可以危及生命。
再三告诉患者家属：不能出院。患者及家属仍坚决要求出院。
患者自有难言苦衷：乳房癌已两肺转移，行化疗每打一针就要1200元，住院半月，医药费又花了15000多元。患病以来，光治疗费用已支出70000多元，身为山村一农家，再也无法凑钱继续治疗。化疗后白血球这么低，恶心呕吐，半个月米粒难进，彻夜难眠，浑身疼痛难熬，真是生不如死。至此,患者悲观绝望，不听住院医师劝阻，离开病房。当天，其丈夫找到了在浙一医院做医师的亲戚商量办法，亲戚告诉他们：等死不是办法，你们最好去找省肿瘤医院中医科陈医师，也许有救。
2002年6月26日，患者来我处求诊：身体极度消瘦虚弱，神情痛楚，面色苍白，夜寐不佳，前胸隐痛，夜间为重，偶有咳嗽，纳少呕恶，舌淡红苔腻，脉细数。
处方：二参30克 佩兰12克 猪茯苓各12克 天冬12克 牡蛎30克先煎 象贝12克 瓜蒌皮12克 每天自取活蟾蜍1只，去肠入药同煎。
2002年10月15日诊：服前方三月有余，诸症缓解，能做家务，偶尔还下地劳动，唯不能持久。患者述说：癞蛤蟆实在难吃，喝时腥气上冲，呕恶，难以入咽，还会腹泻，为了求生，只有硬着头皮喝下去。服了一段日子，慢慢地也就适应了，体力渐增。这次到医院来想复查一下，看看两肺转移灶是增大了还是缩小了。
10月16日,患者拿到了X线摄片(125805号)报告，X线所见：两肺基本清晰，无明确占位，心膈无殊，X线诊断:：两肺无明确占位。
夫妻俩看了报告，见两肺转移性肿瘤经中药治疗已经消失，简直不敢相信自己的眼睛，问了身边的医生、护士，他们都说肺内肿块消失了。又马上跑来问我:陈医生，X线摄片报告说两肺转移灶消失了，这是不是真的？
再续处方,巩固疗效
处方：二参30克 夏枯草30克 牡蛎30克先煎 猪茯苓各12克熬 象贝12克 天冬12克瓜蒌皮12克 每天一只活蟾蜍入药同煎。
身患重病之人在绝望时，总希望有灵丹妙药挽救自己的生命。蟾仙赐福人间，又一个乳房癌术后，放化疗后两肺转移的患者，经活蟾蜍入药治疗两肺转移灶消失了。
活蟾蜍入药治疗肺癌广泛转移
余××，女，68岁。因左侧胸痛3个月，伴咳嗽，气急，经余杭二院纤支镜检查，病理报告：右上肺小细胞癌.
CT报告:：右上肺中央型癌伴纵隔淋巴结转移。 出院诊断： 右上肺癌纵隔转移伴上腔静脉综合症。
因治疗无效于1997年9月11日来我院。证见重病容，头面浮肿，项颈粗大，颈部静脉怒张，面色暗滞，咳喘声粗，呼吸困难，脉浮数，舌紫苔黄。证属邪毒内结，气机阻遏。
治则： 解毒散结，降气化滞。 处方：
半枝莲30克，蛇舌草30克，鱼腥草30克，败酱草30克，夏枯草30克，炒苏子12克，牡蛎30克，苦参30克，米仁30克，石见穿30克，海藻12克，地龙15克，蜈蚣3枚，取活蟾蜍一只去肠入药同煎。每贴煎2汁，分4次饮服，服至10贴后症状缓解，颈静脉怒张明显消退，呼吸平稳。治疗至今已良好存活二年。
按语： 活蟾蜍入药治疗肺癌纵隔转移伴上腔静脉综合症,迅速改善了生存质量,减少痛苦延长生存期。
活蟾蜍单味治疗肺癌
张××，男，50岁。1997年10月20日因咳嗽痰多，经浙一医院活检找到癌细胞。因病人不接受治疗，迨至1998年10月来我院(门诊号167703)摄X线胸片报告：右肺周围型癌。
证见形体消瘦，面色灰黑无华，舌瘦色红苔薄黄。证属热毒瘀结于肺， 治则：清热解毒，消肿镇痛。 处方：
取活蟾蜍每天一只，去肠加黄酒少许，炖汁分三次饮服。
最初几天，服后有轻度腹痛腹泻，尔后遍身奇痒，皮肤有异物钻动，向外爬感。精神逐渐好转，食欲大增，诸症皆愈。1999年5月来院复查时判若两人，面色红润，体重增加20斤，胸片复查肿块由8×6cm，缩小至4×3 cm大小， 随访至今，已带瘤安然生存近四年。
按语：患者是五保户, 确诊肺癌而无钱医治,听天由命, 拖了一年病入膏盲，在奄奄一息之时,单味活蟾蜍有起死回生之功。
活蟾蜍入药治疗肝癌
陈××，男，
51岁，嘉善魏塘镇秀南村村民.。2000年1月29日，因胸胁胀痛两个月，经嘉善县第一人民医院检查，B超报告：肝左外叶可见23×31×30mm大小低回声区。CT片（30809号）示：肝左叶实质内可见大小约2·1×2·1CMcm低密度影，边界不清。
意见： 肝左叶癌伴肝门部淋巴结肿大；血吸虫性肝硬化， 甲胎蛋白阳性。诊断： 肝左叶原发性肝癌，当地治疗效果不佳。 5月份B超报告：肝左外叶见39×36×30mm低密度影。
当月21日,来我处就诊(门诊号2012231)，症见面色青灰，形瘦神疲，夜寐不宁，胸胁疼痛，痛如锥刺，脘腹胀痞，纳食乏味，大便干结，小便短黄，舌红苔黄，舌下脉络曲张，脉弦涩，有长期饮酒史。证属湿热蕴结，瘀血内阻。
处方：茵陈蒿汤合二参一仙汤加味：茵陈15克 生大黄5克后下 山栀12克 当归12克 二参30克 炒三仙各12克 枳壳12克 郁金12克 自取活蟾蜍1只入药同煎。服药后，诸症改善，体重渐增，能参加体力劳动，经多次B超检查，肿块略有增大，甲胎蛋白持续阳性。2001年5月B超检查报告（22852号）：肝左外叶见：81×73×47mm，低回声影。2002年4月，B超报告肝左外叶见10×9.6×5.6cm大小实质性肿块，边界尚清。甲胎蛋白阳性。已带瘤良好生存三年。
按语：肝癌患者的平均存活期很短，仅有几个月，活蟾蜍入药治疗肝癌，延长了生存期并提高了生存质量。
姜××，男，45岁。1997年8月，因右胁下疼痛，经浙二医院检查甲胎蛋白放射免疫>1000纳克/毫升，CT报告："见肝右叶有-低密度肿块阴影，累及右肾，直径约11×10cm大小。"诊断："原发性肝癌肾转移。"经当地治疗无效后来院求治（门诊号0021921）。证见口干且苦，脘胁胀痛，体倦乏力，食纳不馨，尿黄赤便秘结，触诊右胁下肿块约10×12cm大小，质硬，固定，表面高低不平。脉弦细，舌红，边有紫斑，苔薄黄。证属肝郁气滞，热毒壅盛。
处方：逍遥散合膈下逐瘀汤加减，方用柴胡10克 当归10克 杭白芍12克郁金10克 桃仁10克 川芎10克 五灵脂10克 香附10克 炙鳖甲12克 地鳖虫10克 蜂房12克 藤梨根30克 茵陈30克 虎杖30克 取活蟾蜍每天1只去肠入药同煎。服药后食欲增进，两便润肠，脘胁胀痛渐消，面色日见红润，体力增加。3个月后恢复全天工作，以后坚持原方，经5次CT复查肿块未见增大，甲胎蛋白放射免疫>1000纳克/毫升，带瘤良好生存达21个月。
按语：原发性巨块型肝癌肾转移，经活蟾蜍入药治疗延长了生存期。因摸奖得了桑塔娜轿车一辆，付清了医药费用还绰绰有余，又旧习不改，喝酒、搓麻将，"得财伤身，乐极生悲"，疲劳过度，酒精伤肝，致使疾病恶化而身亡。
蟾蜍有效剂量与中毒剂量接近，大凡疗效佳者均有毒性反应发生，尔后大多症状改善，身心轻松。蟾蜍久煎则毒性大减，每天量炖汁分次饮服亦可减轻毒性反应；初服者反应较剧，久服则逐渐适应。个体对蟾蜍剂量适应大不相同，有的每天1只小蟾蜍入煎即呕恶、难受，有的每天五只亦能接受；蟾蜍大者不良反应大，反之则小；山区比池泽的蟾蜍毒性反应大，池泽地比旱地的毒性大；蟾蜍颜色深的黑的，比颜色浅的淡的毒性反应大；蟾蜍头背颗粒大的比颗粒小的毒副反应大；夏天的比冬天的蟾蜍毒性反应大，临床应用时需不断摸索，严谨掌握有效剂量。
3, 中药煎煮、服法之宜
On May 26, 2001, the patient was admitted to Jiaxing Maternal and Child Health Hospital due to "amenorrhea for 3 months, lower abdominal distension and pain for 3 months," with hospitalization number 0044831. Color Doppler ultrasound examination showed: multiple uterine fibroids, heterogeneous solid masses in bilateral adnexa accompanied by ascites. Cytological examination of punctured ascites found cancer cells. Diagnosis: Stage III ovarian cancer, uterine fibroids, endometrial polyps. During surgery on June 2, soybean-sized nodules were observed on the liver surface. The first course of chemotherapy was administered on June 6. On August 13, 2001, the patient underwent a second cytoreductive surgery. Among the sent lymph nodes, left obturator 0/3, left deep femoral 0/3, left external iliac 4/6, left iliac fossa 1/1, right iliac fossa 2/8, right external iliac 3/5, right deep femoral 1/4, totaling 11 metastatic lymph nodes. The fourth course of chemotherapy was performed on the 28th. After the sixth course of chemotherapy on November 14, 2001, the white blood cell count was 3.1×10^9/L, with exhaustion of both physical form and spirit; the patient firmly requested discharge. On December 5 of the same year, she came to my clinic requesting Traditional Chinese Medicine (TCM) treatment.
Ovarian tumors are common gynecological neoplasms, with more than two-thirds of malignant cases occurring in women aged 40-65. Due to the deep location of ovarian tumors within the pelvic cavity, they are asymptomatic in the early stages, and there is a lack of effective early diagnostic and differential methods, leading to most patients being diagnosed at an advanced stage. The five-year survival rate is less than one-quarter, and the mortality rate exceeds the sum of cervical cancer and corpus uteri cancer, making it the most threatening disease among gynecological neoplasms. Ovarian tumors have been recorded in TCM since ancient times. The chapter "Shui Zhang" (Water Swelling) in *Ling Shu* (Spiritual Pivot) states: "Cold initially invades outside the intestines, struggling with Wei Qi (Defensive Qi), preventing Qi from circulating properly. Due to binding and attachment, evil Qi accumulates internally, causing abnormal growths to form. Initially, they are as large as a chicken egg, gradually increasing in size until they resemble a cup. Over time, they become detached from normal tissue structure and feel firm upon palpation." This belongs to the TCM categories of "Zheng Jia" (Masses) and "Ji Ju" (Accumulations). When this patient was admitted to Jiaxing Maternal and Child Health Hospital, cancer cells had already widely metastasized. The two surgeries and chemotherapy were palliative treatments. Given her extreme physical weakness, decreased white blood cell count, and inability to tolerate further chemotherapy, she sought TCM treatment.
Symptoms presented: emaciation and fatigue, pale complexion and dull spirit, palpitations and shortness of breath, lack of physical strength, spontaneous sweating upon exertion, dry mouth without desire to drink, poor appetite, occasional nausea and vomiting, epigastric and abdominal distension and fullness, difficult urination and defecation, pale red tongue with ecchymosis on the sides, greasy coating, and deep, fine, and choppy pulse.
Treatment principle: Support healthy Qi and consolidate the root, soften hardness and eliminate tumors, strengthen Spleen and promote dampness drainage.
Prescription: Huoxiang (Patchouli Herb) 12g, Fuling (Poria) 12g, Chao Cangzhu (Stir-fried Atractylodes Rhizome) 12g, Jiang Xia (Ginger-processed Pinellia Tuber) 12g, Chao Sanxian (Stir-fried Three Digestive Herbs) 12g each, Zhike (Aurantium Fruit) 12g, Danggui (Angelica Sinensis Root) 12g, Ezhu (Curcuma Zedoary Rhizome) 10g. One live Toad (Bufo bufo gargarizans) was taken daily, cleaned, and decocted together with the herbs. Seven doses.
Second visit on December 13: After taking seven doses, the greasy coating has receded, dampness is resolved, appetite has significantly increased, epigastric and abdominal distension has disappeared, and urination and defecation are smooth. The excess pathogenic factors on the branch level have been eliminated. Treatment should continue to support healthy Qi and consolidate the root, invigorate Blood and eliminate masses. Modified Shengmai San (Generate the Pulse Powder).
Prescription: Shengshaishen (Sun-dried Ginseng Root) 9g, Maidong (Ophiopogon Tuber) 12g, Wuweizi (Schisandra Berry) 10g, Danggui (Angelica Sinensis Root) 12g, Ezhu (Curcuma Zedoary Rhizome) 12g, Jiaogulan (Gynostemma Pentaphyllum) 30g, Chuanlianzi (Evodia Fruit) 12g, Banzhilian (Scutellaria Barbata Herb) 30g, Sheqiecao (Hedyotis Diffusa Herb) 30g. One live Toad daily, thirty doses.
Follow-up after one month: Liver function and blood indices were all normal. All symptoms improved significantly; she could manage household chores, only occasionally feeling soreness and pain in both shoulders. Add Sangzhi (Mulberry Twig) 30g, continue taking.
Diagnosis on October 15, 2002: "After taking TCM for 10 months, complexion is lustrous, body is robust, no discomfort, weight increased by over 20 jin (approx. 10 kg)."
Admitted again on November 10 for radiotherapy.
Treatment process: Left supraclavicular area and left internal mammary area treated with 60Co + 10 MeV electron beam, DT 53Gy each. Additionally, CMF regimen chemotherapy was administered for a total of 8 courses.
Review on May 28, 2002, three and a half years post-left breast cancer surgery: CT report indicated multiple metastatic tumors in both lungs. Chest X-ray diagnosis: Post-left breast cancer surgery, nodules in both lungs, metastasis considered first. [Text fragment missing context] able to perform general labor. Ultrasound examination showed: uterus not detected in the pelvic cavity, no masses seen in the pelvic cavity, no space-occupying lesions in the pelvic cavity.
Modern research confirms that toad extracts can inhibit the respiration of human ovarian adenocarcinoma cells in vitro; they can elevate white blood cell counts, enhance the supportive function of the reticuloendothelial system, eliminate toxic and side effects of chemotherapy, and consolidate chemotherapy efficacy; they can also promote diuresis and reduce tumors, resolving various conditions of stasis, congestion, and obstruction, such as accumulated toxins, masses, and distension. Using toad in prescriptions combined with TCM syndrome differentiation and treatment is effective for treating ovarian cancer after chemotherapy.
Live Toad decoction for treating lung metastasis after breast cancer surgery and chemoradiotherapy.
Lin Xianguai, Female, 45 years old, residing in Houyangchen Village, Haiyou Town, Sanmen County. Hospitalization No.: 95620. Outpatient No.: 2026446.
The patient was admitted to Zhejiang Cancer Hospital for surgical treatment on October 16, 1998, and discharged on November 9 with the diagnosis: Left simple breast carcinoma.
Treatment process: Preoperative chemotherapy with CMF regimen 8 days prior (CTX × 0.6g/d, MTX × 30mg/d, 5-FU 0.75g/d). On October 29, radical left mastectomy was performed under general anesthesia, with clearance of axillary upper, middle, and lower groups of lymphatic fatty tissue. On the fifth day post-operation, CMF regimen chemotherapy was administered again. Post-operative pathology report: Small amount of poorly differentiated adenocarcinoma tissue (3/11) residual in left breast scar tissue, foreign body giant cell reaction to suture material. Pathological staging: Stage IIa.
Admitted again on June 3. Discharged on June 25 with diagnosis: Lung metastasis after left breast cancer surgery and chemoradiotherapy.
Treatment process: After admission, NP regimen was administered once every 4 days. Post-operatively, there were discomforts such as nausea and muscle soreness. Re-examination of blood routine showed: White blood cells 1700/mm³, neutrophils 23.4%.
X-ray report on June 24: Pulmonary nodule foci, metastasis considered first.
The attending physician wrote in the discharge summary under discharge condition: Patient has low white blood cell count, highly susceptible to infection, severe cases may endanger life.
Repeatedly told the patient's family: Do not discharge. The patient and family still firmly requested discharge.
The patient had unspoken hardships: Breast cancer had metastasized to both lungs. Each chemotherapy injection cost 1200 yuan. Hospitalization for half a month cost another 15,000+ yuan. Since falling ill, treatment expenses alone exceeded 70,000 yuan. As a farmer in a mountain village, she could no longer gather money for continued treatment. Chemotherapy caused such low white blood cell counts, nausea, vomiting, inability to eat even rice grains for half a month, insomnia all night, unbearable whole-body pain, truly living worse than death. At this point, the patient was pessimistic and desperate, ignoring the resident physician's advice, and left the ward. That day, her husband found a relative working as a doctor at Zhejiang First Hospital to discuss solutions. The relative told them: Waiting for death is not a solution; you had better find Dr. Chen in the TCM Department of the Provincial Cancer Hospital; perhaps there is hope.
On June 26, 2002, the patient came to my clinic: Extremely emaciated and weak, painful expression, pale complexion, poor sleep, dull pain in the anterior chest, worse at night, occasional cough, poor appetite with nausea, pale red tongue with greasy coating, fine and rapid pulse.
Treatment plan: Strengthen Spleen, calm Spirit, support healthy Qi and eliminate tumors. Modified Ershen Yixian Tang (Two Ginsengs and One Immortal Decoction).
Prescription: Ershen (Two Ginsengs) 30g, Peilan (Eupatorium Fortunei Herb) 12g, Zhu Ling (Polyporus) and Fuling (Poria) 12g each, Tiandong (Asparagus Tuber) 12g, Muli (Oyster Shell) 30g (decocted first), Xiangbei (Fritillaria Thunbergii Bulb) 12g, Gualoupi (Trichosanthes Peel) 12g. One live Toad daily, cleaned of entrails, decocted together.
Diagnosis on October 15, 2002: After taking the previous prescription for over three months, all symptoms alleviated; she could do housework and occasionally work in the fields, but could not sustain it for long. The patient stated: The toad is really hard to eat; when drinking, the fishy smell rushes up, causing nausea and difficulty swallowing, and even diarrhea. For the sake of survival, I had to force myself down. After taking it for a while, I gradually adapted, and physical strength gradually increased. Coming to the hospital this time for a re-examination to see if the lung metastasis foci had enlarged or shrunk.
On October 16, the patient received the X-ray film (No. 125805) report. X-ray findings: Both lungs basically clear, no definite space-occupying lesions, heart and diaphragm unremarkable. X-ray diagnosis: No definite space-occupying lesions in both lungs.
The couple looked at the report, seeing that the metastatic tumors in both lungs had disappeared after TCM treatment, hardly believing their eyes. They asked the doctors and nurses nearby, who confirmed that the lung masses had disappeared. They immediately ran back to ask me: Dr. Chen, the X-ray report says the lung metastasis foci have disappeared, is this true?
Continue prescription to consolidate efficacy.
Prescription: Ershen (Two Ginsengs) 30g, Xiakucao (Prunella Vulgaris Spike) 30g, Muli (Oyster Shell) 30g (decocted first), Zhu Ling (Polyporus) and Fuling (Poria) 12g each (boiled), Xiangbei (Fritillaria Thunbergii Bulb) 12g, Tiandong (Asparagus Tuber) 12g, Gualoupi (Trichosanthes Peel) 12g. One live Toad daily, decocted together.
Patients suffering from serious illnesses often hope for a miraculous cure to save their lives when in despair. Blessed by the Toad Immortal, another patient with lung metastasis after breast cancer surgery and chemoradiotherapy had her lung metastasis foci disappear after treatment with live Toad decoction.
Live Toad decoction for treating widespread lung metastasis in lung cancer.
Yu XX, Female, 68 years old. Due to left-sided chest pain for 3 months, accompanied by cough and shortness of breath, flexible bronchoscopy at Yuhang Second Hospital yielded a pathology report: Small cell carcinoma of the right upper lung.
CT report: Central type carcinoma of the right upper lung accompanied by mediastinal lymph node metastasis. Discharge diagnosis: Right upper lung cancer with mediastinal metastasis accompanied by Superior Vena Cava Syndrome.
Due to ineffective treatment, she came to our hospital on September 11, 1997. Symptoms presented: Severe illness appearance, edema of head and face, thick neck, distended jugular veins, dark and dull complexion, coarse coughing and wheezing, dyspnea, floating and rapid pulse, purple tongue with yellow coating. Syndrome belongs to internal binding of evil toxins and obstruction of Qi mechanism.
Treatment principle: Resolve toxins and dissipate nodules, descend Qi and resolve stagnation. Prescription:
Banzhilian (Scutellaria Barbata Herb) 30g, Sheqiecao (Hedyotis Diffusa Herb) 30g, Yuxingcao (Houttuynia Cordata Herb) 30g, Baijiangcao (Patrinia Scabiosifolia Herb) 30g, Xiakucao (Prunella Vulgaris Spike) 30g, Chao Suzi (Stir-fried Perilla Fruit) 12g, Muli (Oyster Shell) 30g, Kushen (Sophora Flavescens Root) 30g, Yiren (Coix Seed) 30g, Shijianchuan (Andrographis Paniculata Herb) 30g, Haizao (Sargassum Herb) 12g, Dilong (Pheretima Earthworm) 15g, Wugong (Centipede) 3 pieces. One live Toad, cleaned of entrails, decocted together. Each dose decocted into two portions, divided into four servings. After taking ten doses, symptoms alleviated, jugular vein distension significantly subsided, breathing became stable. She has survived well for two years since treatment began.
Commentary: Live Toad decoction for treating lung cancer with mediastinal metastasis and Superior Vena Cava Syndrome rapidly improved quality of life, reduced suffering, and extended survival period.
Single herb Live Toad for treating lung cancer.
Zhang XX, Male, 50 years old. On October 20, 1997, due to cough with excessive phlegm, cancer cells were found via biopsy at Zhejiang First Hospital. Because the patient did not accept treatment, by October 1998, when coming to our hospital (Outpatient No. 167703), chest X-ray report showed: Peripheral carcinoma of the right lung.
Symptoms presented: Emaciated body, gray-black lusterless complexion, thin red tongue with thin yellow coating. Syndrome belongs to heat toxin and blood stasis binding in the Lung. Treatment principle: Clear heat and resolve toxins, reduce swelling and relieve pain. Prescription:
One live Toad daily, cleaned of entrails, add a little yellow wine, stew for juice, divide into three servings.
In the first few days, mild abdominal pain and diarrhea occurred after ingestion. Later, strange itching all over the body, sensation of foreign objects burrowing and crawling outwards through the skin. Mental state gradually improved, appetite greatly increased, all symptoms cured. Upon re-examination at the hospital in May 1999, she looked like a different person, ruddy complexion, weight increased by 20 jin (approx. 10 kg), chest X-ray re-examination showed tumor mass shrank from 8×6 cm to 4×3 cm. Follow-up to date, she has lived peacefully with the tumor for nearly four years.
Commentary: The patient was a 'Five Guarantees' household member, diagnosed with lung cancer but without funds for treatment, resigned to fate. Delayed for a year until the disease reached a critical stage. At the brink of death, the single herb live Toad had the power to revive the dying.
Live Toad decoction for treating liver cancer.
Chen XX, Male,
51 years old, villager of Xiunan Village, Weitang Town, Jiashan County. On January 29, 2000, due to chest and hypochondriac distension and pain for two months, examination at Jiashan County First People's Hospital yielded Ultrasound report: Hypoechoic area measuring 23×31×30 mm visible in the left lateral lobe of the liver. CT scan (No. 30809) showed: Low-density shadow approximately 2.1×2.1 cm visible in the parenchyma of the left lobe of the liver, unclear boundaries.
Opinion: Carcinoma of the left lobe of the liver accompanied by hilar lymph node enlargement; Schistosomiasis cirrhosis, Alpha-fetoprotein positive. Diagnosis: Primary hepatocellular carcinoma of the left lobe, local treatment effect was poor. May Ultrasound report: Hypoechoic shadow measuring 39×36×30 mm seen in the left lateral lobe of the liver.
On the 21st of that month, visited my clinic (Outpatient No. 2012231). Symptoms presented: Blue-gray complexion, emaciated body and tired spirit, restless sleep, chest and hypochondriac pain, stabbing pain like awls, epigastric and abdominal distension, tasteless appetite, dry stool, scanty yellow urine, red tongue with yellow coating, tortuous sublingual collaterals, wiry and choppy pulse, history of long-term alcohol consumption. Syndrome belongs to damp-heat accumulation and internal blood stasis obstruction.
Treatment principle: Clear and drain damp-heat, invigorate Blood and eliminate masses.
Prescription: Yinchen Hao Tang (Artemisia Scoparia Decoction) combined with Ershen Yixian Tang (Two Ginsengs and One Immortal Decoction) modified: Yinchen (Artemisia Scopium Herb) 15g, Sheng Dahuang (Raw Rhubarb Root) 5g (added later), Shanzhi (Gardenia Fruit) 12g, Danggui (Angelica Sinensis Root) 12g, Ershen (Two Ginsengs) 30g, Chao Sanxian (Stir-fried Three Digestive Herbs) 12g each, Zhike (Aurantium Fruit) 12g, Yujin (Turmeric Tuber) 12g. One live Toad taken daily, decocted together. After taking medicine, all symptoms improved, weight gradually increased, able to participate in physical labor. After multiple Ultrasound examinations, the mass slightly enlarged, Alpha-fetoprotein remained continuously positive. May 2001 Ultrasound report (No. 22852): Hypoechoic shadow measuring 81×73×47 mm seen in the left lateral lobe of the liver. April 2002, Ultrasound report showed solid mass measuring 10×9.6×5.6 cm in the left lateral lobe of the liver, boundaries relatively clear. Alpha-fetoprotein positive. Has lived well with the tumor for three years.
Commentary: The average survival period for liver cancer patients is very short, only a few months. Live Toad decoction for treating liver cancer extended the survival period and improved quality of life.
Live Toad decoction for treating liver cancer with renal metastasis.
Jiang XX, Male, 45 years old. In August 1997, due to pain under the right hypochondrium, examination at Zhejiang Second Hospital showed Alpha-fetoprotein radioimmunoassay >1000 ng/ml. CT report: "Low-density mass shadow seen in the right lobe of the liver, involving the right kidney, diameter approx. 11×10 cm." Diagnosis: "Primary liver cancer with renal metastasis." After ineffective local treatment, came to our hospital for treatment (Outpatient No. 0021921). Symptoms presented: Dry and bitter mouth, epigastric and hypochondriac distension and pain, body fatigue and weakness, poor appetite, yellow-red urine and constipation, palpation revealed mass under right hypochondrium approx. 10×12 cm, hard, fixed, uneven surface. Wiry and fine pulse, red tongue, purplish spots on edges, thin yellow coating. Syndrome belongs to Liver Qi stagnation and abundant heat toxin.
Treatment principle: Soothe Liver and resolve depression, clear heat and resolve toxins, transform stasis and soften hardness.
Prescription: Xiaoyao San (Free and Easy Wanderer Powder) combined with Gexia Zhuyu Tang (Drive-out Stasis below the Diaphragm Decoction) modified. Formula uses: Chaihu (Bupleurum Root) 10g, Danggui (Angelica Sinensis Root) 10g, Hang Baishao (White Peony Root) 12g, Yujin (Turmeric Tuber) 10g, Taoren (Peach Kernel) 10g, Chuanxiong (Ligusticum Rhizome) 10g, Wulingzhi (Trogopterus Dung) 10g, Xiangfu (Cyperus Rhizome) 10g, Zhi Biejia (Braised Turtle Shell) 12g, Dibiechong (Ground Beetle) 10g, Fengfang (Honeycomb) 12g, Tengligen (Actinidia Arguta Root) 30g, Yinchen (Artemisia Scopium Herb) 30g, Huzhang (Polygonum Cuspidatum Root) 30g. One live Toad daily, cleaned of entrails, decocted together. After taking medicine, appetite increased, bowel movements moistened, epigastric and hypochondriac distension and pain gradually subsided, complexion became ruddy day by day, physical strength increased. Resumed full-time work after 3 months, thereafter adhered to the original formula. After 5 CT re-examinations, the mass did not enlarge, Alpha-fetoprotein radioimmunoassay >1000 ng/ml, lived well with the tumor for 21 months.
Commentary: Primary massive liver cancer with renal metastasis, treated with live Toad decoction, extended the survival period. Won a Santana car in a lottery, paid off medical expenses with plenty left over, yet failed to change old habits, drinking and playing mahjong. "Wealth harms the body, joy begets sorrow," excessive fatigue and alcohol damage to the liver caused disease deterioration and death.
The effective dose of Toad is close to the toxic dose. Generally, those with good efficacy experience toxic reactions, after which most symptoms improve, and body and mind feel relaxed. Long decoction of Toad significantly reduces toxicity; daily dose stewed into juice and taken in divided doses can also alleviate toxic reactions; initial responders react severely, but long-term users gradually adapt. Individual adaptation to Toad dosage varies greatly; some vomit and feel uncomfortable with just one small Toad daily, while others can accept five daily; larger Toads have greater adverse reactions, smaller ones less; Toads from mountain areas have greater toxic reactions than those from ponds, pond environments greater than dry land; darker black Toads have greater toxic reactions than lighter ones; Toads with larger granules on the head and back have greater toxic side effects than those with smaller granules; summer Toads have greater toxic reactions than winter Toads. Clinical application requires continuous exploration and rigorous control of the effective dose.
3. Appropriateness of TCM decoction and administration methods