喜泰顺曰∶痘疮发毒，多见于外靥之证。脓浆溃烂，何由而足，虽云变臭，生意已成，必发痈毒，方为稳兆。发于
四肢
则伤手足，发于头顶硬处为佳。内服消风化毒汤，外用生黄豆嚼而敷之。此险中得顺，百无一失也。
邵慈庵曰∶凡有迟延日久而起，不圆润而靥，既平之际，又发痈肿，人固知其
余毒，而不知为何经，当辨之。但气高喘急，胸满肚壮者，余毒在肺也。痰涎稠粘，
口咬嘎齿，泄泻不止，口臭者，余毒在脾胃也。盗汗热不退而渴者，余毒在心也。梦
中多惊，余毒在肝也。耳朵尚热，余毒在肾也。眼合不开，身肿不消，内热不清，郁闷不乐者，余毒诸经皆有矣。
《心法》曰∶痘后余毒发出，小如李者为毒，大如桃者为痈。单生一个者，毒在
肌肉，属顺易治；连发数处者，船小载重，属险。若结于骨节之间，或成对发出者，其
毒已盛；溃破之后，渗泄气血，不能敛，已属逆证。
陈实功曰∶痘痈即是痘毒。缘溜浆不足，毒流于脾肺二经，致手脚胸背结成漫
肿，大如桃李。此多发于收靥之后，身凉不渴者吉。初起嚼生黄豆敷之自消；已成
用太乙膏贴，侯脓熟针之。元气虚弱者，保元汤助脾健胃为主。（《正宗》）
胡公弼曰∶痘痈宜大连翘饮主之。大便秘加酒炒大黄微利之，如疹后风疮加金银花。
窦汉卿曰∶发于面项胸胁者难治，生四肢者易治。
澄曰∶凡痘后发热，即是余毒未尽，不曾多服败毒药，防发痘毒，宜仔细脱衣看视，乘早消除。
又曰∶发于关键要害处，及气血亏败者险。
又曰∶痘毒切不可开刀。
喜泰顺说：痘疮发出的毒邪，多见于外靥（痘疹结痂脱落）阶段的证候。脓浆溃烂，怎么能算好呢？虽然说是变臭，但生机已经形成，必定发出痈毒，这才是稳妥的征兆。发于四肢则损伤手足，发于头顶坚硬处为吉兆。内服消风化毒汤，外用生黄豆嚼碎后敷贴患处。这是险中求顺，百无一失的方法。
邵慈庵说：凡是病程拖延日久才起发，痘形不圆润且结痂时，在即将平复之际，又发出痈肿，人们固然知道这是余毒，但不知道是哪条经络的余毒，应当加以辨别。如果气逆喘急，胸满腹胀者，是余毒在肺经。痰涎稠粘，咬牙磨齿，泄泻不止，口臭者，是余毒在脾胃经。盗汗、热不退且口渴者，是余毒在心经。梦中多惊悸，是余毒在肝经。耳朵尚热，是余毒在肾经。眼睛闭合不开，身体浮肿不消退，内热不清爽，心情郁闷不快乐者，是余毒遍布各条经络了。
《心法》说：痘后余毒发出，小如李子的是“毒”，大如桃子的是“痈”。单生一个的，毒在肌肉，属于顺证，容易治疗；连续发多处者，如同小船载重，属于险证。若结聚在骨节之间，或成对发出的，其毒已经很盛；溃破之后，渗流血和津液，不能收敛，已经属于逆证。
陈实功说：痘痈就是痘毒。因为溜浆（出痘时浆液充盈）不足，毒邪流窜到脾、肺二经，导致手脚、胸背结成漫肿，大小如桃李。这多发于收靥（痘疹收口结痂）之后，身体凉爽且不口渴者为吉。初起时嚼生黄豆敷贴可自消；已成脓时用太乙膏贴敷，等到脓熟后用针穿刺排脓。元气虚弱的人，以保元汤扶助脾胃为主。（出自《外科正宗》）
胡公弼说：痘痈适宜用大连翘饮主治。大便秘结加酒炒大黄轻微通利，如疹后风疮加金银花。
窦汉卿说：发于面部、颈部、胸部、胁部的难治，发于四肢的易治。
顾澄说：凡是痘后发热，就是余毒未尽，没有多服用败毒药物，预防痘毒发作，应该仔细脱衣查看，尽早消除。
又说：发于关键要害部位，以及气血亏败的人是危险的。
Xi Taishun stated: The manifestation of toxin from smallpox is mostly seen in the syndrome of the outer crusts (the stage when pustules form and crust over). When pus and fluid ulcerate, how can it be considered sufficient? Although it is said to become foul-smelling, the vital energy has already been established. It must manifest as carbuncles and sores to be a stable omen. If it occurs on the four limbs, it damages the hands and feet; if it occurs on the hard part of the top of the head, it is auspicious. Internally administer Xiaofeng Huadu Decoction (Wind-Dispersing and Toxin-Resolving Decoction); externally, chew raw soybeans and apply the paste to the affected area. This is a method of finding safety within danger, with virtually no failure.
Shao Ci'an stated: Whenever there is a delay in duration before eruption, and the lesions are not round and smooth during crusting, and just as they are flattening out, carbuncles and swellings appear again. People naturally know this is residual toxin, but do not know which meridian it belongs to, and thus should differentiate it. If there is Qi rebellion with panting and urgency, chest fullness, and abdominal distension, the residual toxin is in the Lung Meridian. If there are thick and sticky phlegm and saliva, teeth grinding, incessant diarrhea, and bad breath, the residual toxin is in the Spleen and Stomach meridians. If there is night sweating, unrelenting fever, and thirst, the residual toxin is in the Heart. If there are frequent fright dreams, the residual toxin is in the Liver. If the ears are still hot, the residual toxin is in the Kidney. If the eyes cannot open, the body remains swollen without subsiding, internal heat is not cleared, and there is depression and unhappiness, the residual toxin is present in all meridians.
The *Xinfa* states: After smallpox, when residual toxin manifests, if it is as small as a plum, it is called "toxin" (Du); if it is as large as a peach, it is called "carbuncle" (Yong). If a single one appears, the toxin is in the muscles, belonging to a favorable syndrome that is easy to treat; if multiple areas erupt consecutively, it is like a small boat carrying heavy weight, belonging to a dangerous syndrome. If it knots between bone joints, or appears in pairs, the toxin is already abundant; after ulceration, if blood and Qi seep out and cannot coalesce, it has already become an unfavorable syndrome.
Chen Shigong stated: Carbuncles following smallpox are simply smallpox toxin. Due to insufficient filling of the pustules with fluid, the toxin flows into the Spleen and Lung meridians, causing diffuse swelling on the hands, feet, chest, and back, as large as plums or peaches. This mostly occurs after the scabs have formed. If the body is cool and there is no thirst, it is auspicious. At the initial stage, chewing raw soybeans and applying them externally will cause it to resolve spontaneously; once suppurated, apply Taiyi Plaster, and when the pus is ripe, puncture it with a needle. For those with deficient Yuan Qi, Baoyuan Decoction (Protective Qi Decoction) should be used primarily to support the Spleen and strengthen the Stomach. (From *Zhengzong*)
Hu Gongbi stated: Carbuncles following smallpox should primarily be treated with Da Liaoqiao Yin (Large Liaoqiao Drink). If there is constipation, add wine-fried Rhubarb to mildly promote bowel movement; if there are wind-sores after rash, add Honeysuckle Flower.
Dou Hanqing stated: Those occurring on the face, neck, chest, and hypochondrium are difficult to treat; those occurring on the four limbs are easy to treat.
Cheng stated: Whenever there is fever after smallpox, it means the residual toxin is not yet exhausted. If one has not taken more detoxifying medicines to prevent the eruption of smallpox toxin, one should carefully undress and inspect, eliminating it as early as possible.
He also stated: Occurrence at critical and vital points, or in cases of depleted Qi and Blood, is dangerous.
He also stated: Smallpox toxin must never be incised with a knife.